2012
DOI: 10.4172/2153-0602.1000111
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Bioinformatics and Evolution of Vertebrate Pancreatic Lipase and Related Proteins and Genes

Abstract: Background: Pancreatic lipase (PTL) functions in the presence of colipase in the hydrolysis of emulsified fats in the small intestine following secretion from the pancreas. Pancreatic lipase related protein 1 (PLR1) is also found in pancreatic secretions and may perform a regulatory role in lipolysis; PLR2 catalyses pancreatic triglyceride and galactolipase reactions while PLR3 may serve a related but unknown lipase function. Comparative PTL, PLR1, PLR2 and PLR3 amino acid sequences and structures and gene loc… Show more

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Cited by 5 publications
(6 citation statements)
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“…Pancreatic lipase has been reported in zebrafish Danio rerio [8], rainbow trout Oncorhynchus mykiss [9], top minnow Triportheus sp. [10] and in the hepatopancreas of sardine Sardinella longiceps [11].…”
Section: Introductionmentioning
confidence: 99%
“…Pancreatic lipase has been reported in zebrafish Danio rerio [8], rainbow trout Oncorhynchus mykiss [9], top minnow Triportheus sp. [10] and in the hepatopancreas of sardine Sardinella longiceps [11].…”
Section: Introductionmentioning
confidence: 99%
“…These sequences had 35% (contig 106 versus 114 and 554) to 49% (114 versus 154) identity. When compared with human pancreatic lipase-related protein 2/PNLIPRP2 ( Figure 7 ) the three important active site residues (S,D,H) could be retrieved for at least two of the three sequences, with the first serine replaced by a glycine in the contig 106 protein [ 75 ]. While at least four of the cysteine residues were conserved, most of those involved in disulfide bonds in the human protein were absent.…”
Section: Resultsmentioning
confidence: 99%
“…The acid can be aspartic or glutamic acid. In the sequence of LvFSH, we propose that the catalytic triad residues are Ser111, Asp169, and His196 (Figure 1d) [3,49,54]. The residues of the catalytic triad are situated at the C terminal end.…”
Section: Resultsmentioning
confidence: 99%