Bioinformatics Analysis Reveals Significant Genes and Pathways to Targetfor Oral Squamous Cell Carcinoma

Jiang, Qian; Yu, Youcheng; Ding, Xiaobo; Liu, Yin; Ruan, Hong

doi:10.7314/apjcp.2014.15.5.2273

Cited by 19 publications

(11 citation statements)

References 36 publications

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“…NNMT is therefore strongly suggested as a prognostic marker in OSCC. Further, Jiang et al's micro-array analysis revealed remarkable NNMT up-regulation in OSCC compared to normal tissue [36] and it is therefore reasonable to expect NNMT to be successful as a new molecular target in OSCC therapy.…”

Section: Role Of Nnmt In Cancermentioning

confidence: 99%

Nicotinamide N-methyltransferase as a potential marker for cancer

Lu¹,

Long²

2018

neo

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Cancer is the main leading cause of death in the world, although it has been made noteworthy advances in cancer research in the past decades. Early detection of cancer is extremely important in improving the chances of successful therapy. Thus, it is urgently needed to make further efforts to explore novel tumor markers for treatment. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme which catalyzes the N-methylation of nicotinamide to form 1-methylnicotinamide (1-MNA), and plays an important role in controlling the intracellular concentration of nicotinamide. Nicotinamide, the precursor to NAD+, is an important cofactor that associates cellular redox states with energy metabolism. Growing evidence shows that NNMT protein levels are elevated in a variety of human cancers, and increased NNMT expression has been linked to tumor aggressiveness. This paper presents a review for the role of NNMT expressed in a series of human cancers and the regulating mechanism involved, and offers its potential value of NNMT in cancer detection and treatment.

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Section: Role Of Nnmt In Cancermentioning

confidence: 99%

Nicotinamide N-methyltransferase as a potential marker for cancer

Lu¹,

Long²

2018

neo

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“…Recent computational approach into microarray technology has enabled researchers to generate large amounts of data which include approximately the entire known human genome, and has shown that many gene alterations can be involved in carcinogenesis (Bibikova et al, 2004;Nazmul-Hossain et al, 2008;Kim and Kim, 2010;Jiang et al, 2014). In this experiment, a bead array platform of microarray technology was applied for the screening of methylation status of genes (Bibikova et al, 2004), to discover the epigenetic signatures that distinguish normal from tumour tissues of OSCC.…”

Section: Introductionmentioning

confidence: 99%

Screening of Differential Promoter Hypermethylated Genes in Primary Oral Squamous Cell Carcinoma

Heah

Froemming

Zain

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Promoter hypermethylation leads to altered gene functions and may result in malignant cellular transformation. Thus, identification of biomarkers for hypermethylated genes could be useful for diagnosis, prognosis, and therapeutic treatment of oral squamous cell carcinoma (OSCC). Objectives: To screen hypermethylated genes with a microarray approach and to validate selected hypermethylated genes with the methylation-specific polymerase chain reaction (MSPCR). Materials and Methods: Genome-wide analysis of normal oral mucosa and OSCC tissues was conducted using the Illumina methylation microarray. The specified differential genes were selected and hypermethylation status was further verified with an independent cohort sample of OSCC samples. Candidate genes were screened using microarray assay and run by MSPCR analysis. Results: TP73, PIK3R5, and CELSR3 demonstrated high percentages of differential hypermethylation status. Conclusions: Our microarray screening and MSPCR approaches revealed that the signature candidates of differentially hypermethylated genes may possibly become potential biomarkers which would be useful for diagnostic, prognostic and therapeutic targets of OSCC in the near future.

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“…With the use of computational methods, numerous studies have discovered that several cancers are markedly triggered by epigenetic alterations (Mahdavi et al, 2012;Wu et al, 2013;Jiang et al, 2014;Song et al, 2014;Zhuo e t al., 2014;Wang and Yan, 2015). The present study was also an attempt to determine the in silico interaction of MIC and 1,3-dimethylurea with several domains of DNMT1.…”

Section: Discussionmentioning

confidence: 99%

In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas-Tragedy survivors

Khan¹,

Senthilkumar²,

Upadhyay³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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DNA methyltransferase 1 (DNMT1) is a relatively large protein family responsible for maintenance of normal methylation, cell growth and survival in mammals. Toxic industrial chemical exposure associated methylation misregulation has been shown to have epigenetic influence. Such misregulation could effectively contribute to cancer development and progression. Methyl isocyanate (MIC) is a noxious industrial chemical used extensively in the production of carbamate pesticides. We here applied an in silico molecular docking approach to study the interaction of MIC with diverse domains of DNMT1, to predict cancer risk in the Bhopal population exposed to MIC during 1984. For the first time, we investigated the interaction of MIC and its hydrolytic product (1,3-dimethylurea) with DNMT1 interacting (such as DMAP1, RFTS, and CXXC) and catalytic (SAM, SAH, and Sinefungin) domains using computer simulations. The results of the present study showed a potential interaction of MIC and 1,3-dimethylurea with these domains. Obviously, strong binding of MIC with DNMT1 interrupting normal methylation will lead to epigenetic alterations in the exposed humans. We suggest therefore that the MICexposed individuals surviving after 1984 disaster have excess risk of cancer, which can be attributed to alterations in their epigenome. Our findings will help in better understanding the underlying epigenetic mechanisms in humans exposed to MIC.

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Bioinformatics Analysis Reveals Significant Genes and Pathways to Targetfor Oral Squamous Cell Carcinoma

Cited by 19 publications

References 36 publications

Nicotinamide N-methyltransferase as a potential marker for cancer

Nicotinamide N-methyltransferase as a potential marker for cancer

Screening of Differential Promoter Hypermethylated Genes in Primary Oral Squamous Cell Carcinoma

In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas-Tragedy survivors

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