Bioinformatics Analysis Reveals Ki-67 Specific microRNA Functions in Pediatric Embryonal Tumors

Braoudaki, Maria; Sarafidis, Michail; Koutsouris, Dimitrios; Koutsouri, Georgia; Lambrou, George Ι.

doi:10.1109/embc.2019.8857896

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…In the present approach we used high throughput expression data and processed them to find common expression patterns between different childhood CNS tumors. There are numerous works concerning the role of miRNAs in CNS tumors, such as childhood embryonal tumors [ 1 , 18 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ], astrocytoma [ 24 , 47 , 48 ], glioblastoma [ 49 , 50 , 51 ], ependymoma [ 52 ] and others. Yet, all the previous studies concerned the role of miRNAs in specific tumor types.…”

Section: Discussionmentioning

confidence: 99%

Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics

Lambrou

Zaravinos

Braoudaki

2021

Cancers

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Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. MicroRNAs are known to be involved in CNS tumor oncogenesis. We hypothesized that CNS tumors possess commonly deregulated miRNAs across different CNS tumor types. Aim: The current study aims to reveal the co-deregulated miRNAs across different types of pediatric CNS tumors. Materials: A total of 439 CNS tumor samples were collected from both in-house microarray experiments as well as data available in public databases. Diagnoses included medulloblastoma, astrocytoma, ependydoma, cortical dysplasia, glioblastoma, ATRT, germinoma, teratoma, yoc sac tumors, ocular tumors and retinoblastoma. Results: We found miRNAs that were globally up- or down-regulated in the majority of the CNS tumor samples. MiR-376B and miR-372 were co-upregulated, whereas miR-149, miR-214, miR-574, miR-595 and miR-765 among others, were co-downregulated across all CNS tumors. Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. Conclusions: Our approach could prove significant in the search for global miRNA targets for tumor diagnosis and therapy. To the best of our knowledge, there are no previous reports concerning the present approach.

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