Bioinformatics analysis of lncRNA‑associated ceRNA network in melanoma

Ding, Yi; Li, Min; Tayier, Tuersong; Zhang, Meilin; Chen, Long; Feng, Shumei

doi:10.7150/jca.51851

Cited by 13 publications

(11 citation statements)

References 41 publications

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“…let-7b was significantly decreased in melanoma compared to benign melanocytic lesions and also presented a significant association with key clinicopathological factors, such as Breslow index, ulceration, and AJCC pT staging [ 60 ]. let-7a-5p expression was previously reported to be directly correlated with OS standing as an independent prognostic factor in melanoma [ 61 ] but was inversely correlated with OS in lung malignant tumors [ 62 ]. High expression was also found to prevent lung adenocarcinoma by inhibiting keratin 5 (KRT5) expression [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…The downregulation of let-7a-5p is known to influence cancer aggressiveness. In colorectal cancer, let-7a-5p downregulation can be predictive of a worse outcome [ 61 ] by enhancing proliferation and vascular invasion [ 64 , 65 ]. NEAT1 ( Nuclear paraspeckle assembly transcript 1 ), a long noncoding RNA, was reported to interact with let-7a-5p, with both being inversely correlated [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma

Beleaua

Jung²,

Braicu

et al. 2021

IJMS

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Although skin melanoma (SKM) represents only one-quarter of newly diagnosed skin malignant tumors, it presents a high mortality rate. Hence, new prognostic and therapeutic tools need to be developed. This study focused on investigating the prognostic value of the subcellular expression of BRAF, KRAS, and KIT in SKM in correlation with their gene-encoding interactions. In silico analysis of the abovementioned gene interactions, along with their mRNA expression, was conducted, and the results were validated at the protein level using immunohistochemical (IHC) stains. For IHC expression, the encoded protein expressions were checked on 96 consecutive SKMs and 30 nevi. The UALCAN database showed no prognostic value for the mRNA expression level of KRAS and BRAF and demonstrated a longer survival for patients with low mRNA expression of KIT in SKMs. IHC examinations of SKMs confirmed the UALCAN data and showed that KIT expression was inversely correlated with ulceration, Breslow index, mitotic rate, and pT stage. KRAS expression was also found to be inversely correlated with ulceration and perineural invasion. When the subcellular expression of BRAF protein was recorded (nuclear vs. cytoplasmatic vs. mixed nucleus + cytoplasm), a direct correlation was emphasized between nuclear positivity and lymphovascular or perineural invasion. The independent prognostic value was demonstrated for mixed expression of the BRAF protein in SKM. BRAF cytoplasmic predominance, in association with KIT’s IHC positivity, was more frequently observed in early-stage nonulcerated SKMs, which displayed a low mitotic rate and a late death event. The present study firstly verified the possible prognostic value of BRAF subcellular localization in SKMs. A low mRNA expression or IHC cytoplasmic positivity for KIT and BRAF might be used as a positive prognostic parameter of SKM. SKM’s BRAF nuclear positivity needs to be evaluated in further studies as a possible indicator of perineural and lymphovascular invasion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma

Beleaua

Jung²,

Braicu

et al. 2021

IJMS

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“…In MM, most of the differentially expressed genes were associated with EMT. LINC00520 can promote EMT by regulating the LINC00520/let-7a-5p/DTL axis ( 17 ).…”

Section: The Cerna Network Of Linc00520 In Cancermentioning

confidence: 99%

“…LINC00520 is abnormally upregulated in 11 cancers, including lung cancer (11), non-small cell lung cancer (NSCLC) (10), lung adenocarcinoma (LUAD) (12,13), breast cancer (BC) (4,8), papillary thyroid carcinoma (PTC) (14), colorectal cancer (CRC) (15), melanoma (MM) (16)(17)(18), head and neck squamous cell carcinoma (HNSCC) (19), laryngeal squamous cell carcinoma (LSCC) (20), glioma (9), nasopharyngeal carcinoma (NPC) (21), etc. Further in vitro experiments have shown that LINC00520 significantly promotes tumor progression by controlling the proliferation and other biological functions of cancer cells (14,21) (Table 1).…”

Section: The Aberrant Expression Of Linc00520 In Cancermentioning

confidence: 99%

LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer

Zhang

Shen

et al. 2022

Front. Immunol.

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Long non-coding RNA (lncRNA) is important in the study of cancer mechanisms. LINC00520 is located on human chromosome 14q22.3 and is a highly conserved long non-coding RNA. LINC00520 is widely expressed in various tissues. The expression of LINC00520 is regulated by transcription factors such as Sp1, TFAP4, and STAT3. The high expression of LINC00520 is significantly related to the risk of 11 cancers. LINC00520 can competitively bind 10 miRNAs to promote tumor cell proliferation, invasion, and migration. In addition, LINC00520 is involved in the regulation of P13K/AKT and JAK/STAT signaling pathways. The expression of LINC00520 is significantly related to the clinicopathological characteristics and prognosis of tumor patients and is also related to the sensitivity of HNSCC to radiotherapy. Here, this article summarizes the abnormal expression pattern of LINC00520 in cancer and its potential molecular regulation mechanism and points out that LINC00520 can be used as a potential biomarker for cancer diagnosis, prognosis, and treatment.

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“…Skin Cutaneous Melanoma (SKCM) is a primary malignant tumor that originates from benign moles ( Cramer, 1991 ). It is derived from neural crest stem cells, which can produce melanin in the skin ( Ding et al, 2021 ). Nevis will not develop into melanoma in most cases ( Damsky and Bosenberg, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

FAT10 is a Prognostic Biomarker and Correlated With Immune Infiltrates in Skin Cutaneous Melanoma

Wang

2022

Front. Mol. Biosci.

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Background: Skin Cutaneous Melanoma (SKCM) is the deadliest cutaneous neoplasm. Previous studies have proposed ubiquitin-like protein FAT10 plays key roles in the initiation and progression of several types of human cancer, but little is known about the interrelation between FAT10 gene expression, tumor immunity, and prognosis of patients with SKCM.Methods: Here, we first performed pan-cancer analysis for FAT10’s expression and prognosis using the Cancer Genome Atlas and the Genotype-Tissue Expression data. Subsequently, we investigated the mRNA expression level, prognostic value, and gene-gene interaction network of FAT10 in SKCM using the Oncomine databases, GEPIA, TIMER, UALCAN, and starBase. The relationship between FAT10 expression and tumor immune invasion was studied by using the TIMER database. Additionally, the expression and functional status of FAT10 in SKCM were evaluated by the single-cell RNA sequencing and CancerSEA databases.Results: In this study, we found that FAT10 expression was increased in SKCM and was correlated with a better survival rate in patients with SKCM. Moreover, we identified FAT10 level was significantly positively associated with immune infiltrates, biomarkers of immune cells, and immune checkpoint expression, and negatively correlated with tumor cell invasion and DNA damage, indicating that increased FAT10 expression in SKCM was a favorable response to immune checkpoint inhibitors.Conclusion: Our findings suggest that upregulation of FAT10 correlated with better prognosis and tumor immune infiltration in SKCM.

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Bioinformatics analysis of lncRNA‑associated ceRNA network in melanoma

Cited by 13 publications

References 41 publications

Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma

Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma

LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer

FAT10 is a Prognostic Biomarker and Correlated With Immune Infiltrates in Skin Cutaneous Melanoma

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