Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus

Rao, Allam Appa; Sridhar, G. R.; Srinivas, B; Das, Undurti N.

doi:10.1016/j.mehy.2007.03.034

Cited by 27 publications

(16 citation statements)

References 23 publications

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“…BDNF is strongly associated with type 2 diabetes. BDNF has an important influence on the pathogenesis of obesity and type 2 diabetes because it modulates the secretion and activities of insulin, leptin, ghrelin, neurotransmitters/neuropeptides and pro-inflammatory cytokines associated with energy homeostasis (63). Animal studies have also shown that BDNF has important effects on the regulation of eating behaviour, suggesting that BDNF may play a pathogenic role in the development of obesity and type 2 diabetes in humans (64).…”

Section: Discussionmentioning

confidence: 99%

Depression and Risk for Diabetes: A Meta-Analysis

Zhang

et al. 2015

Canadian Journal of Diabetes

186

119

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Section: Discussionmentioning

confidence: 99%

Depression and Risk for Diabetes: A Meta-Analysis

Zhang

et al. 2015

Canadian Journal of Diabetes

186

119

View full text Add to dashboard Cite

“…It has been reviewed that animals having BDNF deficiency, also have important influence on the regulation of eating behavior and modulation of the secretion and activities of insulin, leptin, ghrelin and proinflammatory cytokines associated with energy homeostasis (Fig. 2) [24][25][26]. Epidemiologic studies also indicate that patients with type 2 diabetes are at greater risk of depression in association with lower serum BDNF levels compared to non-diabetic individuals [24,[27][28][29].…”

Section: Bdnf and Depressionmentioning

confidence: 99%

Effect of Brain Derived Neurotrophic Factor, In Relation to Diet and Lifestyle Factors, for Prevention of Neuropsychiatric and Vascular Diseases and Diabetes

Singh¹,

Takahashi²,

Tokunaga³

et al. 2014

TONUTRAJ

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Abstract:Background: Brain-derived neurotrophic factor (BDNF) is a major neurotrophin which may have promise to be a nutraceutical of this decade. It has a documented role in neurogenesis, angiogenesis, and neuronal survival. BDNF can have beneficial effects on several cardio-metabolic and neuro-psychiatric disorders, indicating that it is important in brainbody interactions. Diet and lifestyle factors may also have an influence on BDNF levels. In this review, we examine the beneficial role of BDNF on risk factors of vascular diseases, type 2 diabetes mellitus and anxiety disorders. Methods: Internet search and discussion with peer colleagues. Results: Majority of the BDNF (70-80%) is derived from dendrite of neurons but it is also present in other body tissues. BDNF controls the food intake and appetite as well as lipid and glucose metabolism. Sedentary behavior and tobacco intake may be associated with BDNF deficiency. Lower serum concentration of BDNF and higher vascular endothelial growth factor (VEGF) concentrations were associated with increased risk of incident stroke/TIA. BDNF may serve as an intermediate biomarker for subclinical vascular disease and may also have biological potential to serve as a therapeutic target for primary and secondary prevention of vascular diseases, as well as clinical and subclinical vascular brain disease. BDNF deficiency has been observed in association with anxiety, depression, insomnia, dementia, insulin resistance, type 2 diabetes and vascular diseases. The phenotypes associated with insulin resistance are at increased risk for developing cognitive decline and neuro-degeneration resulting in vascular dementia, and depression as well as diabetes mellitus and metabolic syndrome, which are risk factors for CVDs. BDNF may be administered as nutraceutical due to its protective influence on BDNF concentrations, insulin receptors and hypothalamic dysfunction leading to beneficial effects on cardiovascular risk and neuropsychological dysfunction. It is proposed that omega-3 fatty acids and moderate physical activity may enhance BDNF release. Conclusions: It is possible that circulating BDNF deficiency is a risk factor for obesity, CVDs and diabetes as well as risk factor for neuropsychiatric diseases. BDNF administration may modify the risk of clinical and subclinical stroke, depression, and dementia as well as of obesity and type 2 diabetes.

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“…The number of patients diagnosed with diabetes and obesity has increased significantly in recent years [4]. DM leads to islet dysfunction, causing a series of comprehensive metabolic disorders associated with sugars, proteins, fats, or electrolytes [5], and the appearance of high blood sugar causes glycosuria [6]. Although the symptoms of each type of diabetes are generally similar, the causes and population distributions differ.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols

Chen

2017

Journal of Diabetes Research

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Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11.4%, the treatment rate is 48.2%, and the mortality rate is 2.7% worldwide. Comprehensive and effective control of diabetes, as well as the use of insulin, requires further study to develop additional treatment options. Here, we reviewed the current reprogramming of somatic cells using specific factors to induced pluripotent stem (iPS) cells capable of repairing islet β cell damage in diabetes patients to treat patients with type 1 diabetes mellitus. We also discuss the shortcomings associated with clinical use of iPS cells. Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes.

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Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus

Cited by 27 publications

References 23 publications

Depression and Risk for Diabetes: A Meta-Analysis

Depression and Risk for Diabetes: A Meta-Analysis

Effect of Brain Derived Neurotrophic Factor, In Relation to Diet and Lifestyle Factors, for Prevention of Neuropsychiatric and Vascular Diseases and Diabetes

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols

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