Bioinformatic Comparative Analysis of Lovastatin Gene Cluster in Endophytic Fungi and a Soil Fungus, Aspergillus terreus

Janakiraman, Savitha

doi:10.15406/mojpb.2014.01.00026

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…This strain was grown in several agro-based natural media to select the best substrate for increased yield of lovastatin (5). Genetic and bioinformatic analysis of the whole genome of the lovastatin-producing soil isolate A. terreus (AH007774) revealed the presence of the lovastatin gene cluster (6, 7). Using the existing nucleotide sequence information and devising suitable primers, the target PCR amplification of the two important genes, lov E (1,512 bp) and lov F (749 bp), were successful in cDNA (7) and genomic DNA (unpublished data) of A. terreus (KM017963).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Genome Sequence of Soil Fungus Aspergillus terreus (KM017963), a Potent Lovastatin Producer

2016

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Section: Genome Announcementmentioning

confidence: 99%

Complete Genome Sequence of Soil Fungus Aspergillus terreus (KM017963), a Potent Lovastatin Producer

2016

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Bioprocessing of Two Crop Residues for Animal Feeding into a High-Yield Lovastatin Feed Supplement

Ábrego-García

Poggi‐Varaldo

Ponce-Noyola

et al. 2022

Animals

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This work aimed to evaluate the lovastatin (Lv) production by solid-state fermentation (SSF) from selected crop residues, considering the post-fermented residues as feed supplements for ruminants. The SSF was performed with two substrates (wheat bran and oat straw) and two A. terreus strains (CDBB H-194 and CDBB H-1976). The Lv yield, proximate analysis, and organic compounds by GC–MS in the post-fermented residues were assessed. The combination of the CDBB H-194 strain with oat straw at 16 d of incubation time showed the highest Lv yield (23.8 mg/g DM fed) and the corresponding degradation efficiency of hemicellulose + cellulose was low to moderate (24.1%). The other three treatments showed final Lv concentrations in decreasing order of 9.1, 6.8, and 5.67 mg/g DM fed for the oat straw + CDBB H-1976, wheat bran + CDBB H-194, and wheat bran + CDBB H-1976, respectively. An analysis of variance of the 22 factorial experiment of Lv showed a strong significant interaction between the strain and substrate factors. The kinetic of Lv production adequately fitted a zero-order model in the four treatments. GC–MS analysis identified only a couple of compounds from the residues fermented by A. terreus CDBB H-194 (1,3-dipalmitin trimethylsilyl ether in the fermented oat straw and stearic acid hydrazide in the fermented wheat bran) that could negatively affect ruminal bacteria and fungi. Solid-state fermentation of oat straw with CDBB H-194 deserves further investigation due to its high yield of Lv; low dietary proportions of this post-fermented oat straw could be used as an Lv-carrier supplement for rumen methane mitigation.

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Bioinformatic Comparative Analysis of Lovastatin Gene Cluster in Endophytic Fungi and a Soil Fungus, Aspergillus terreus

Cited by 2 publications

References 11 publications

Complete Genome Sequence of Soil Fungus Aspergillus terreus (KM017963), a Potent Lovastatin Producer

Complete Genome Sequence of Soil Fungus Aspergillus terreus (KM017963), a Potent Lovastatin Producer

Bioprocessing of Two Crop Residues for Animal Feeding into a High-Yield Lovastatin Feed Supplement

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