Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System
Xianpeng Li,
Shuaiqi Yang,
Xiangmin Zhang
et al.
Abstract:The Roquin family is a recognized RNA-binding protein family that plays vital roles in regulating the expression of pro-inflammatory target gene mRNA during the immune process in mammals. However, the evolutionary status of the Roquin family across metazoans remains elusive, and limited studies are found in fish species. In this study, we discovered that the RC3H genes underwent a single round of gene duplication from a primitive ancestor during evolution from invertebrates to vertebrates. Furthermore, there w… Show more
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