Abstract:Beta-thalassemia is delineated as a bunch of heritable blood disorders characterized by abnormalities within the synthesis of beta chains of hemoglobin. Most defects in hemoglobin arise directly from mutations in the structure of the β-globin sequence (HBB). Recent advances in computational tools have made it possible to study the relationship between genotype and phenotype in many diseases, including β-thalassemia. Due to the high prevalence of β-thalassemia, these analyses have helped to know the molecular b… Show more
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