2020
DOI: 10.31083/j.jin.2020.04.203
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Bioinformatic analysis of a microRNA regulatory network in Huntington’s disease

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Cited by 12 publications
(6 citation statements)
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“…Huntington disease is a hereditary neurodegenerative condition which impacts in early forties and fifties. 24 , 79 Dysregulation of possible biomarkers has recently been found to be linked with neurological and neurodegenerative diseases, 80 , 81 and several studies have looked into the implications of biomolecular activities in patients with HD. 27 , 82 - 85 Omics-based approaches are currently being used more often in biomedicine and systemic biology studies, and they have proven to be a helpful resource for deciphering disease pathogenesis, discovering molecular pathways, and determining biomarkers for various diseases.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Huntington disease is a hereditary neurodegenerative condition which impacts in early forties and fifties. 24 , 79 Dysregulation of possible biomarkers has recently been found to be linked with neurological and neurodegenerative diseases, 80 , 81 and several studies have looked into the implications of biomolecular activities in patients with HD. 27 , 82 - 85 Omics-based approaches are currently being used more often in biomedicine and systemic biology studies, and they have proven to be a helpful resource for deciphering disease pathogenesis, discovering molecular pathways, and determining biomarkers for various diseases.…”
Section: Discussionmentioning
confidence: 99%
“… 20 , 22 Due to prolonged CAG repeat, HTT protein with an enlarged polyglutamine tract is produced, resulting in pathogenic HTT protein residues that are immune to the protein cycle, leading to cellular toxicity. 23 , 24 Most HD patients have motor-involved problems, a small percentage (15%) establish clinically relevant psychological disease first and hence have a mental diagnosis before the start of movement disorder. 20 , 25 Huntington disease is associated with extremely selective deterioration of the corpus striatum which is a brain region with no noticeable abnormalities in peripheral tissues.…”
Section: Introductionmentioning
confidence: 99%
“…Shaohong Isaac Peng, 1,2,8 Zhefan Stephen Chen, 1,2,8 Lok I Leong, 1,2 Xiao Lin, 2 Yuming Wei, 1,2 Alex Chun Koon, 1,2 Junzhe Huang, 3 Jacquelyne Ka-Li Sun, 2 Kin Ming Kwan, 2,4,5 Hei-Man Chow, 2,7 Ho Ko, 3,6 Ting-Fung Chan, 2,4,7 and Ho Yin Edwin Chan…”
Section: Declaration Of Interestsunclassified
“…Several studies have reported that microRNA (miRNA) homeostasis is perturbed in polyQ diseases, 4 including HD. 5,6,7 miRNAs are small non-coding RNAs and are components of the RNA-induced silencing complex (RISC), which guides the post-transcriptional silencing of mRNA targets. 8 Supplementation with miRNAs has been shown to be a potential therapeutic strategy against HD in mice.…”
Section: Introductionmentioning
confidence: 99%
“…A smaller number of studies have explored the miRNA profiles in HD. These profiles are found in the brain [ 159 , 160 , 161 ], plasma [ 162 ], and CSF [ 163 ] of HD patients and in the brain of HD mouse models [ 164 , 165 , 166 , 167 ]. No common miRNAs are found between the profiles performed in HD patients, but there are two miRNAs, miR-10b-5p and miR-10a-5p, that are upregulated in the brain of both HD patients and mouse models.…”
Section: Epigenetic Changes In Prion-like Diseasesmentioning
confidence: 99%