Bioindicators in the MIDUS National Study: Protocol, Measures, Sample, and Comparative Context

Love, Gayle D.; Seeman, Teresa E.; Weinstein, Maxine; Ryff, Carol D.

doi:10.1177/0898264310374355

Cited by 271 publications

(254 citation statements)

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“…52 Moreover, new directions for health disparities research should include multiple levels of analysis, specifically those that are environmental, sociocultural, behavioral and biological. 9 NIA-supported projects such as the Healthy Aging in Neighborhoods of Diversity Across the Lifespan Study (HAN-DLS), 53 the Midlife Development in the United States Study (MIDUS), 54 and the Health and Retirement Study (HRS) 55 provide data that permit these types of analyses. Moreover, NIA-supported investigators are developing interdisciplinary teams to move in this direction.…”

Section: Resultsmentioning

confidence: 99%

The National Institute on Aging Health Disparities Research Framework

et al. 2015

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Objective: Development of a new framework for the National Institute on Aging (NIA) to assess progress and opportunities toward stimulating and supporting rigorous research to address health disparities.Design: Portfolio review of NIA’s health disparities research portfolio to evaluate NIA’s progress in addressing priority health disparities areas. Results: The NIA Health DisparitiesResearch Framework highlights important factors for health disparities research related to aging, provides an organizing structure for tracking progress, stimulates opportunities to better delineate causal pathways and broadens the scope for malleable targets for intervention, aiding in our efforts to address health disparities in the aging population. Conclusions: The promise of health disparitiesresearch depends largely on scientific rigor that builds on past findings and aggressively pursues new approaches. The NIA Health Disparities Framework provides a landscape for stimulating interdisciplinary approaches, evaluating research productivity and identifying opportunities for innovative health disparities research related to aging. Ethn Dis. 2015;25(3):245-254.

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Section: Resultsmentioning

confidence: 99%

The National Institute on Aging Health Disparities Research Framework

et al. 2015

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“…Of these, 1,001 respondents participated in the MIDUS Biomarker Project. The Biomarker Project required an overnight stay at one of three General Clinical Research Centers (UCLA, Georgetown, and the University of Wisconsin, Madison), where participants provided blood samples and were assessed for physical health and psychophysiological function (38). The order and timing of data collection varied among participants.…”

Section: Methodsmentioning

confidence: 99%

Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Sin

Graham‐Engeland

Almeida

2015

Brain, Behavior, and Immunity

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Background Inflammation is implicated in the development of chronic diseases and increases the risk of mortality. People who experience more daily stressors than others have higher levels of inflammation, but it is unknown whether daily positive events are linked to inflammation. Objective To examine the association of daily positive events with 3 inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen. Method A cross-sectional sample of 969 adults aged 35–86 from the Midlife in the United States Study completed telephone interviews for 8 consecutive evenings. Participants reported positive experiences that occurred over the past 24 hours. Blood samples were obtained at a separate clinic visit and later assayed for inflammatory markers. Regression analyses evaluated the frequency of daily positive events (defined as the percent of study days with at least 1 positive event) as a predictor of each inflammatory marker. Covariates included information on demographics, physical health, depressive symptoms, dispositional and behavioral factors, and daily positive and negative affect. Results On average, participants experienced positive events on 73% of days (SD = 27%). The frequency of daily positive events was associated with lower IL-6 (p < 0.001) and CRP (p = 0.02) in the overall sample, and lower fibrinogen among women (p = 0.01). The association remained for IL-6 in the fully adjusted model, but was no longer significant for CRP and fibrinogen after controlling for household income and race. Effects were more pronounced for participants in the lowest quartile of positive event frequency than for those in the top 3 quartiles, suggesting that lack of positivity in daily life may be particularly consequential for inflammation. Furthermore, interpersonal positive events were more predictive of lower IL-6 overall and lower fibrinogen in women than non-interpersonal positive events. Conclusion Daily positive events may serve a protective role against inflammation.

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“…Participants were assigned to data collection sites based on their place of residence, and data were collected during a 24-h stay at one of three General Clinical Research Centers (Washington, DC; Los Angeles, CA; Madison, WI) between July 2004 and May 2009. The protocol included a physical exam,12-h overnight urine sample and fasting morning blood draw (for details of the protocol, see Dienberg Love et al, 2010). Individuals participating in the biomarker protocol were comparable with the larger MIDUS 2 sample on demographic and health characteristics with the exception that participants in the biological protocol were less likely to smoke, more likely to have a college degree, and less likely to have completed only high school or some college (Dienberg Love et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Social status and biological dysregulation: The “status syndrome” and allostatic load

Seeman

Merkin

Karlamangla

et al. 2014

Social Science & Medicine

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Data from a national sample of 1255 adults who were part of the MIDUS (Mid-life in the U.S.) follow-up study and agreed to participate in a clinic-based in-depth assessment of their health status were used to test the hypothesis that, quite part from income or educational status, perceptions of lower achieved rank relative to others and of relative inequality in key life domains would be associated with greater evidence of biological health risks (i.e., higher allostatic load). Results indicate that over a variety of status indices (including, for example, the person’s sense of control, placement in the community rank hierarchy, perception of inequality in the workplace) a syndrome of perceived relative deprivation is associated with higher levels of biological dysregulation. The evidence is interpreted in light of the well-established associations between lower socio-economic status and various clinically identified health morbidities. The present evidence serves, in effect, both as a part of the explanation of how socio-economic disparities produce downstream morbidity, and as an early warning system regarding the ultimate health effects of currently increasing status inequalities.

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Bioindicators in the MIDUS National Study: Protocol, Measures, Sample, and Comparative Context

Cited by 271 publications

References 10 publications

The National Institute on Aging Health Disparities Research Framework

The National Institute on Aging Health Disparities Research Framework

Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Social status and biological dysregulation: The “status syndrome” and allostatic load

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