Bioimpedance Body Measures and Serum Lipid Levels in Masculine Depression

Zimmermann, Claudia von; Brückner, Lukas; Mühle, Christiane; Weinland, Christian; Kornhuber, Johannes; Lenz, Bernd

doi:10.3389/fpsyt.2022.794351

Cited by 5 publications

(2 citation statements)

References 41 publications

(59 reference statements)

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“…Although this represents the sole contrasting sex-specific effect observed in our investigation, it is important to note that different biological mechanisms in males and females regarding depression have been documented [ 58 ] and warrant further exploration. Moreover, the concept of masculine depression, which refers to alternative depression symptoms more commonly associated with the male gender, such as externalizing behaviors, emotional suppression, substance misuse, and risk-seeking [ 59 , 60 , 61 ], deserves further attention.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression

Brazdis,

von Zimmermann,

Lenz

et al. 2024

IJMS

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Due to the high comorbidity of Parkinson’s disease (PD) with major depressive disorder (MDD) and the involvement of sphingolipids in both conditions, we investigated the peripheral expression levels of three primarily PD-associated genes: α-synuclein (SNCA), lysosomal enzyme β-glucocerebrosidase (GBA1), and UDP-glucose ceramide glucosyltransferase (UGCG) in a sex-balanced MDD cohort. Normalized gene expression was determined by quantitative PCR in patients suffering from MDD (unmedicated n = 63, medicated n = 66) and controls (remitted MDD n = 39, healthy subjects n = 61). We observed that expression levels of SNCA (p = 0.036), GBA1 (p = 0.014), and UGCG (p = 0.0002) were higher in currently depressed patients compared to controls and remitted patients, and expression of GBA1 and UGCG decreased in medicated patients during three weeks of therapy. Additionally, in subgroups, expression was positively correlated with the severity of depression and anxiety. Furthermore, we identified correlations between the gene expression levels and PD-related laboratory parameters. Our findings suggest that SNCA, GBA1, and UGCG analysis could be instrumental in the search for biomarkers of MDD and in understanding the overlapping pathological mechanisms underlying neuro-psychiatric diseases.

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Section: Discussionmentioning

confidence: 99%

Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression

Brazdis,

von Zimmermann,

Lenz

et al. 2024

IJMS

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“…The data analyzed here were collected as part of the Masculine Depression Project [ 36 , 48 ] aiming to gain more knowledge about the masculine depression. It was conducted as a prospective, open-label, comparative cohort study with one single data collection point per participant.…”

Section: Methodsmentioning

confidence: 99%

Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!

Zimmermann

Hübner

Mühle

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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The gender role influences vulnerability to mental illness. Substance use, even critical in scale, is perceived as masculine, just like hard (over-)work, while not seeking help. With the ongoing separation between gender and sex, masculine norms become more relevant also to females’ mental health. The male depression concept highlights the role of male symptoms in affective disorders. However, the empirical evidence is still limited. Here, we use the denomination ‘masculine depression’ to open the category for female patients and tested substance use patterns, health services’ utilization, and working hours as predictors in a case–control study of 163 depressed in-patients (44% women; masculine vs. non-masculine depression according to a median split of the Male Depression Rating Scale-22) and 176 controls (51% women). We assessed higher depression severity in patients with masculine (vs. non-masculine) depression. Masculine depression (vs. non-masculine depression and vs. no depression) was predicted by more frequent and critical use of alcohol (including binge drinking), tobacco, and illicit drugs, and by longer working times. Moreover, fewer health services contacts due to mental complaints during the previous year were associated with masculine (vs. non-masculine) depression. Alarmingly, even critical substance misuse was not significantly associated with more frequent health services contacts; however, the higher the depression severity, the more contacts the patients reported. Here, we provide evidence that patients with masculine depression are highly burdened and undertreated, which applies equally to female and male patients. This study identified promising targets to establish specialized care offers.

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Body mass index interacts with sex to predict readmission in in‐patients with alcohol use disorder

et al. 2022

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A previous highly controlled pilot study revealed that body mass index (BMI) predicts outcome of in‐patients with alcohol use disorder (AUD) in a sex‐specific manner. We here provide translational evidence from a daily clinical routine setting and investigated whether BMI and sex interact to predict 24‐month readmission risk in four naturalistic cohorts of a specialized addiction clinic (i.e., all patients admitted to the clinic from 2016 to 2020): (i) in‐patients (443 males and 197 females) and (ii) day clinic patients (241 males and 103 females) with a primary diagnosis of AUD; (iii) in‐patients (175 males and 98 females) and (iv) day clinic patients (174 males and 64 females) with a primary substance use disorder (SUD) other than alcohol. In the in‐patients with AUD, BMI interacted with sex to predict the 24‐month readmission risks (p = 0.008; after adjustment for age and liver enzyme activities: p = 0.012); with higher BMI, the risk increases significantly in males, whereas for females, the risk tends to decrease. In the group of overweight in‐patients, we found higher readmission rates in males relative to females with an odds ratio of 1.8 (p = 0.038). No such significant effects were found in the other cohorts. This study's findings support previous results, suggesting that the easily accessible BMI may serve as a predictive and sex‐sensitive biomarker for outcome in in‐patients with AUD. Future studies are necessary to elucidate the underlying aetiopathological mechanisms.

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Bioimpedance Body Measures and Serum Lipid Levels in Masculine Depression

Cited by 5 publications

References 41 publications

Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression

Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression

Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!

Body mass index interacts with sex to predict readmission in in‐patients with alcohol use disorder

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