Bioimaging: Supramolecules‐Guided Synthesis of Brightly Near‐Infrared Au<sub>22</sub> Nanoclusters with Aggregation‐Induced Emission for Bioimaging (Part. Part. Syst. Charact. 12/2019)

Wei, Yifei; Luan, Weiling; Gao, Feng; Hou, Xinyu

doi:10.1002/ppsc.201970032

Cited by 3 publications

(2 citation statements)

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“…[ 46 ] For example, Luan and co‐workers synthesized Au 22 nanoclusters guided by the supramolecular assembly with bright near‐infrared AIE fluorescence for bioimaging, thus providing a new strategy to prepare different kinds of protein‐protected Au nanoclusters for biomedical application. [ 47 ]…”

Section: Supramolecular Self‐assembly Of Aiegensmentioning

confidence: 99%

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

et al. 2020

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health concerns across the world. [1] Particularly significant is the effort directed toward the treatment of cancer, which has remained as one of the leading causes of rapidly growing morbidity and mortality rates for centuries. Among a number of significant advances achieved in this domain, cancer theranostics is one such advancement that allows the ingenious integration of accurate diagnosis with therapeutic intervention in a single formulation within spatial colocalization. This phenomenon has captivated the interest of researchers for the evaluation of the potential in fundamental studies and clinical application, [2] primarily due to the attribution of various intrinsic advantages to theranostics, including maximized therapeutic efficacy, optimized drug safety, and improved pharmacokinetics. [3] Notably, in comparison with the conventional therapeutic methods for cancers such as surgical removal, chemotherapy, and radiotherapy, [4] theranostics involves some burgeoning therapeutic strategies including photothermal therapy (PTT), [5] photodynamic therapy (PDT), [6] and gene therapy. It has become one of the most intensive areas of research during recent years due to high efficiency, minimal side effects, excellent tumor suppression, and non-invasive conversion. One of the major pursuits of biomedical science is to develop advanced strategies for theranostics, which is expected to be an effective approach for achieving the transition from conventional medicine to precision medicine. Supramolecular assembly can serve as a powerful tool in the development of nanotheranostics with accurate imaging of tumors and real-time monitoring of the therapeutic process upon the incorporation of aggregation-induced emission (AIE) ability. AIE luminogens (AIEgens) will not only enable fluorescence imaging but will also aid in improving the efficacy of therapies. Furthermore, the fluorescent signals and therapeutic performance of these nanomaterials can be manipulated precisely owing to the reversible and stimuli-responsive characteristics of the supramolecular systems. Inspired by rapid advances in this field, recent research conducted on nanotheranostics with the AIE effect based on supramolecular assembly is summarized. Here, three representative strategies for supramolecular nanomaterials are presented as follows: a) supramolecular self-assembly of AIEgens, b) the loading of AIEgens within nanocarriers with supramolecular assembly, and c) supramolecular macrocycle-guided assembly via host-guest interactions. Meanwhile, the diverse applications of such nanomaterials in diagnostics and therapeutics have also been discussed in detail. Finally, the challenges of this field are listed in this review.

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Section: Supramolecular Self‐assembly Of Aiegensmentioning

confidence: 99%

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

et al. 2020

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“…Ultrafine metal nanoclusters (AgNCs and AuNCs, etc.) with excellent luminescence properties exhibit outstanding performance in analyzing, sensing, and bioimaging. − AuNCs stand out in bioimaging on account of their high biocompatibility, excellent photostability, and large Stokes shift. − However, the luminescent quantum yield (QY) of AuNCs is generally lower than that of quantum dots and organic dyes. − To date, there are still few reports on AuNCs with QY over 20% in aqueous solution, which severely limits their applicability in bioimaging and luminescence detection. − In view of this, several strategies such as doping with metal ions (Ag and Cu), − host–guest assembly, − and embedding in polymer matrixes , have been adopted to enhance luminescent performances. Among them, the host–guest assembly strategy is an effective and simple measure to suppress the nonradiative transitions of AuNCs via multiple noncovalent interactions between the rigid host macrocycles and the surface ligands of AuNCs.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

Jiang

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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The high biocompatibility and excellent photostability of Au nanoclusters (AuNCs) make them stand out in the bioimaging of nanoparticles. However, the low quantum yield and inferior targeting ability of water-soluble AuNCs greatly limit their biological applications. In this study, we designed and synthesized multifunctional host polymers PolySC 4 AP and FGGC@AuNCs to fabricate PolySC 4 AP/FGGC@AuNC assemblies via a host−guest interaction based on SC 4 (sulfonatocalix[4]arene) and positively charged FGGC ligands (phenylalanine-glycine-glycine-cysteine). Owing to the host−guest assembly strategy and rigid polymer matrix, the quantum yield of FGGC@AuNCs was significantly promoted from 7.0 to 35.3%, accompanied by considerable morphological changes of FGGC@AuNCs. Moreover, PolySC 4 AP/ FGGC@AuNCs could monitor the location of mitochondria along with R (Pearson's correlation coefficients) value for the colocalization as high as 0.9605, which provided a novel strategy for targeted bioimaging with luminophore.

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A fluorescent probe for turn‐on sensing of glutathione using red emitting gold nanoclusters

Varghese,

Madanan,

Abraham

et al. 2024

ChemistrySelect

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Glutathione (GSH), an oxidative stress biomarker plays a major role in different pathological processes and lead to a vast number of diseases including cancer. Biologically, cystine uptake is a fundamental factor in maintaining GSH levels in cells; however, the interaction between cystine and GSH in biological systems is least explored in developing sensors for GSH. In the present work, we have explored this interaction as the fundamental factor in “turn‐on” sensing of GSH from body fluids using a fluorescent gold nanocluster platform. The experimental results revealed that the probe displayed appreciable performance for GSH over a linear range from 0.2 mM to 1.3 mM with a limit of detection (LoD) of 0.43 μM. The probe also revealed sensitive as well as selective response towards GSH even in the presence of possible co‐existing interferants and provided satisfactory recovery percentage of 94.17 % to 108.12 % from real serum samples. These findings of the present study can be extended in future applications of sensing GSH from clinical samples.

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Bioimaging: Supramolecules‐Guided Synthesis of Brightly Near‐Infrared Au₂₂ Nanoclusters with Aggregation‐Induced Emission for Bioimaging (Part. Part. Syst. Charact. 12/2019)

Cited by 3 publications

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Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

A fluorescent probe for turn‐on sensing of glutathione using red emitting gold nanoclusters

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Bioimaging: Supramolecules‐Guided Synthesis of Brightly Near‐Infrared Au22 Nanoclusters with Aggregation‐Induced Emission for Bioimaging (Part. Part. Syst. Charact. 12/2019)

Cited by 3 publications

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Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Multifunctional Host Polymers Assist Au Nanoclusters Achieve High Quantum Yield and Mitochondrial Imaging

A fluorescent probe for turn‐on sensing of glutathione using red emitting gold nanoclusters

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Bioimaging: Supramolecules‐Guided Synthesis of Brightly Near‐Infrared Au₂₂ Nanoclusters with Aggregation‐Induced Emission for Bioimaging (Part. Part. Syst. Charact. 12/2019)