Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe

Yu, Fabiao; Han, Xiaoyue; Xing, Yanlong; Song, Xinyu; Dou, Kun; Chen, Lingxin

doi:10.1039/d3tb00893b

Cited by 8 publications

(1 citation statement)

References 43 publications

(45 reference statements)

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“…The collapsed balance of high oxidative stress and low antioxidant capacities is one of the important causes of the development and progression of HCC. Oxiglutathione, showing favorable binding with LRRC41 in our study, and its related enzymes, plays an important role in the endogenous antioxidant system in the human body ( Han et al, 2023 ). Although there is no clear conclusion of GSH variation in HCC patients ( Sanabria et al, 2016 ; Shimomura et al, 2017 ), GSH and its related enzymes seem to play important roles in protecting against HCC progression.…”

Section: Discussionmentioning

confidence: 68%

Targeting LRRC41 as a potential therapeutic approach for hepatocellular carcinoma

Li,

Qin,

et al. 2023

Front. Mol. Biosci.

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Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, characterized by high mortality rate. In clinical practice, several makers of liver cancer, such as VEGFR1, FGFR1 and PDGFRα, were identified and their potentials as a therapeutic target were explored. However, the unsatisfied treatment results emphasized the needs of new therapeutic targets.Methods: 112 HCC patients samples were obtained to evaluate the expression of LRRC41, SOX9, CD44, and EPCAM in HCC, combined with prognosis analysis. A DEN-induced HCC rat model was constructed to verify the expression of LRRC41 and SOX9 in HCC and lung metastasis tissues. Immune score evaluation was analysized by bioinformatics methods. Network pharmacology was performed to explored the potential FDA-approved drugs targeting LRRC41.Results: Through analysis of the Timer database and tissue micro-array, we confirmed that LRRC41 was over-expressed in HCC and exhibited a significant positive correlation with recurrence and metastasis. Immunohistochemistry staining of human HCC tissue samples revealed significant upregulation of LRRC41, SOX9, CD44, and EPCAM, with LRRC41 showing a positive correlation with SOX9, CD44, and EPCAM expression. UALCAN database analysis indicated that LRRC41 and SOX9 contribute to poor prognosis whereas CD44 and EPCAM did not demonstrate the same significance. Furthermore, analysis of a DEN-induced HCC rat model confirmed the significantly elevated expression of LRRC41 and SOX9 in HCC and lung metastasis tissues. Drug sensitivity analysis and molecular docking targeting LRRC41 identified several FDA-approved drugs, which may have potential antitumor effects on HCC by targeting LRRC41.Conclusion: Our findings highlight the role of LRRC41 overexpression in promoting HCC progression and its association with a poor prognosis. Drug sensitivity analysis and molecular docking shows several FDA-approved drugs may be potential therapeutic targets for HCC. Targeting LRRC41 may hold promise as a potential therapeutic strategy for HCC.

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Section: Discussionmentioning

confidence: 68%

Targeting LRRC41 as a potential therapeutic approach for hepatocellular carcinoma

Li,

Qin,

et al. 2023

Front. Mol. Biosci.

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A lysosome-targeted fluorescent probe for thiol detection in drug analysis and multiple biological systems

Liu,

Song,

et al. 2024

Anal Bioanal Chem

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A FRET-based multifunctional fluorescence probe for the simultaneous detection of sulfite and viscosity in living cells

Zhang,

Wu,

Wei

et al. 2024

Bioorganic Chemistry

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Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe

Abstract: Reliable biomarkers is crucial for early diagnosis of diseases and precise therapy. Biological thiols (represented with glutathione, GSH) play vital roles in the antioxidant defense system for maintaining intracellular redox...

Cited by 8 publications

References 43 publications

Targeting LRRC41 as a potential therapeutic approach for hepatocellular carcinoma

Targeting LRRC41 as a potential therapeutic approach for hepatocellular carcinoma

A lysosome-targeted fluorescent probe for thiol detection in drug analysis and multiple biological systems

A FRET-based multifunctional fluorescence probe for the simultaneous detection of sulfite and viscosity in living cells

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