Biohydrogen process development on waste sorghum (Sorghum bicolor) leaves: Optimization of saccharification, hydrogen production and preliminary scale up

This study aimed to investigate the potential use of aqueous extract of Sorghum bicolor leaf sheath (SBLS) as a coating agent for paracetamol tablets. The mechanical properties of the coated tablets were assessed using crushing strength and friability test, while the release properties of the tablet were evaluated using disintegration and dissolution tests. The physicochemical properties of the coated tablets did not show any striking differences when compared with the uncoated tablet as par compendium specifications, which formed the basis for performing further in vitro dissolution study. Our data showed that SBLS enhanced the hardness and friability of the tablets in a dose-dependent manner. Tablets coated with 3, 5, and 7.5% of SBLS disintegrated in 8.13, 6.25, and 4.13 minutes, respectively, while the uncoated tablet disintegrated in 0.7 minutes. Furthermore, 3, 5, and 7.5% of SBLS-coated tablets exhibited slower release of their active ingredient (releasing 21, 16, and 17%, respectively) than that of the uncoated tablet (releasing 40%) in 5 minutes. Besides, comparison between the dissolution profiles was successfully achieved using difference factor (f1) and similarity factor (f2). The apparent dissimilarity between our coated tablets and the uncoated one led to further study of convolution in vitro–in vivo correlation, with the aim to obtain data that converted into mathematical prediction of in vivo data. For all batches, the percent predictable errors of C max and T max were within the acceptable limit of no more than 10%. In summary, SBLS aqueous extract is a potential and protective coat agent for paracetamol tablets. The in vitro established dissolution of the coated tablets provided scientific information for the prediction of the in vivo plasma drug profile.

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“…►Table 1 shows the organoleptic properties of SBLS, which were all in agreement with established findings from reported works. [1][2][3]…”

Section: Resultsmentioning

confidence: 99%

“…Sorghum bicolor (L.) Moench, one of the species of sorghum plant found in West Africa, is cultivated mainly for grain and as a fodder plant for pasture. 3 It differs from other species of S. bicolor in their intense dark brown pigmentation. Every part of the plant, from the stalk, to the leaves, and to the seed, can be useful.…”

Section: Introductionmentioning

confidence: 95%

Finding Use for Sorghum Bicolor Leaf Sheath in Coating Technology

Isaac

Fasuba

2021

Pharmaceutical Fronts

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“…Other commonly used enteric bacteria, such as Escherichia coli and [45] heat at 100 � C for 176 min 5.95% HCl -47.3 mL/g sugar should be considered to understand the selected feedstock and the principles of the principal technologies used, i.e. dark and photo fermentation, and their combined 2-step application.…”

Section: Dark Fermentationmentioning

confidence: 99%

Reviewing the potential of bio-hydrogen production by fermentation

Baeyens

Zhang

Nie

et al. 2020

Renewable and Sustainable Energy Reviews

173

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“…It is noteworthy to mention that biofuel-related technologies are in their early stages in South Africa and about 200 small-scale biofuel plants have been built and run, but this number is likely to increase in the next few years due to government policies aiming at strengthening the development of alternative fuels [418]. Fundamental research afforts on DF studies are also being expended in some South Africa institutions such as Durban University of Technology, University of the Witwatersrand, and the University of KwaZulu-Natal to contribute to the development of this technology [419][420][421][422][423][424][425][426].…”

Section: The South African Scenariomentioning

confidence: 99%

Revising the dark fermentative H2 research and development scenario – An overview of the recent advances and emerging technological approaches

Sekoai

Daramola

Mogwase

et al. 2020

Biomass and Bioenergy

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The indiscriminate use of fossil fuels has led to several challenges such as greenhouse gas emissions, environmental degradation, and energy security. Establishment of clean fuels is at the forefront of science and innovation in today's society to curb these problems. Dark fermentation (DF) is widely regarded as the most promising clean energy technology of the 21st century due to its desirable properties such as high energy content, its non-polluting features, its ability to use a broad spectrum of feedstocks and inoculum sources, as well as its ability to use mild fermentation conditions. In developing nations, this technology could be instrumental in establishing effective waste disposal systems while boosting the production of clean fuels. However, DF is still hindered by the low yields which stagnate its commercialization. This paper reviews the recent and emerging technologies that are gaining prominence in DF based on information that has been gathered from recent scientific publications. Herein, novel enhancement methods such as cell immobilization, nanotechnology, mathematical optimization tools, and technologies for biogas upgrading using renewable H 2 are comprehensively discussed. Furthermore, a section which discusses the potential of bioenergy in Sub-Saharan Africa including South Africa is included. Finally, scientific areas that need further research and development in DF process are also presented.

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Biohydrogen process development on waste sorghum (Sorghum bicolor) leaves: Optimization of saccharification, hydrogen production and preliminary scale up

Cited by 48 publications

References 34 publications

Finding Use for Sorghum Bicolor Leaf Sheath in Coating Technology

Finding Use for Sorghum Bicolor Leaf Sheath in Coating Technology

Reviewing the potential of bio-hydrogen production by fermentation

Revising the dark fermentative H2 research and development scenario – An overview of the recent advances and emerging technological approaches

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