Biohydrogels for medical applications: A short review

Abstract

Hydrogels have been widely used as drug delivery systems for scaffold production (in different soft and hard tissue engineering, including bones), thanks to their biocompatibility and biodegradability. In addition to the possibility of synthesizing a wide range of hydrogels from various natural and synthetic polymers, they are suitable for scaffold production. Moreover, they can have antimicrobial, antitumor and analgesic functions due to their intrinsic properties or through addition of proper biologically active agents. In this article, different types of hydrogels are reviewed alongside their application areas. Different methods are applied for the preparation of hydrogels and their compositions, and are strongly correlated with the morphological and mechanical properties of the synthesized hydrogels, which had a great influence on the performances of the respective scaffolds. The most effective ways to produce the desired scaffolds are mold casting, especially, 3D printing and electrospinning due to the ability to manipulate and control the shape and size of the desired scaffold as well as their microstructure.

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

“…Hydrogels swell by absorbing a huge amount of fluid and, in this state, they are rubbery soft and tend to show excellent similarity to living tissues [11]. Hydrogels made of polysaccharides are used as drug carriers in pharmaceutical applications thanks to their biocompatible, biodegradable, and non-toxic properties, and the controlled release ability [13][14][15]. In this study, natural polysaccharides, chitosan (CS) and β-cyclodextrin (β-CD) were used to synthesize the hydrogel.…”