Biohybrid robot powered by an antagonistic pair of skeletal muscle tissues

Morimoto, Yuya; Onoe, Hiroaki; Takeuchi, Shoji

doi:10.1126/scirobotics.aat4440

Cited by 203 publications

(237 citation statements)

References 32 publications

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“…Such robot was composed of a 3D‐printed resin skeleton bearing electrodes for the active stimulation of myoblast‐laden hydrogel sheets, which were mounted on two sides of the skeleton to act as antagonist muscles (Figure b). The authors showed that the biohybrid robot was capable of large movements (rotation angle of the joint was close to 90°) that can be used to perform simple actions (e.g., grabbing and transporting small objects) . Furthermore, they showed that the hybrid robot was successfully actuated over a long period of time (≈1 week).…”

Section: Skeletal Muscle Tissue Engineeringmentioning

confidence: 99%

Section: Skeletal Muscle Tissue Engineeringmentioning

confidence: 99%

“…The authors showed that the biohybrid robot was capable of large movements (rotation angle of the joint was close to 90°) that can be used to perform simple actions (e.g., grabbing and transporting small objects). [102] Furthermore, they showed that the hybrid robot was successfully actuated over a long period of time (≈1 week). Despite much success, this research field is still at its infancy and additional work will be needed to develop reliable hybrid robots for advanced applications.…”

Section: D Printing and Bioprinting In Skeletal Muscle Tissue Enginementioning

confidence: 99%

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3D Bioprinting in Skeletal Muscle Tissue Engineering

Ostrovidov

Salehi

Costantini

et al. 2019

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166

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Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments are made in SMTE; however, it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. Here, after a brief description of the anatomy of skeletal muscle and a short state‐of‐the‐art on developments made in SMTE with “conventional methods,” the use of 3D bioprinting as a new tool for SMTE is in focus. The current bioprinting methods are discussed, and an overview of the bioink formulations and properties used in 3D bioprinting is provided. Finally, different advances made in SMTE by 3D bioprinting are highlighted, and future needs and a short perspective are provided.

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Section: Skeletal Muscle Tissue Engineeringmentioning

confidence: 99%

Section: Skeletal Muscle Tissue Engineeringmentioning

confidence: 99%

Section: D Printing and Bioprinting In Skeletal Muscle Tissue Enginementioning

confidence: 99%

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3D Bioprinting in Skeletal Muscle Tissue Engineering

Ostrovidov

Salehi

Costantini

et al. 2019

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220

166

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“…Following, there are less-concrete distinctions among modes of (non-)aliveness compared to our traditional understandings of those states (Jipson & Gelman, 2007). For instance, biohybrid robots combine organic components (like cultured muscle tissues) with machine components (like gels, electrodes, and metal frameworks) so that electrical stimulation allows the robot to perform humanlike behaviors like joint movement (see Morimoto, Onoe, & Takeuchi, 2018). Hence, when a biohybrid robot moves a hand or a finger, is that agent somehow alive?…”

Section: Ontological Shiftsmentioning

confidence: 99%

Toward an Agent-Agnostic Transmission Model: Synthesizing Anthropocentric and Technocentric Paradigms in Communication

Banks¹,

Graaf

2020

HMC

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Technological and social evolutions have prompted operational, phenomenological, and ontological shifts in communication processes. These shifts, we argue, trigger the need to regard human and machine roles in communication processes in a more egalitarian fashion. Integrating anthropocentric and technocentric perspectives on communication, we propose an agent-agnostic framework for human-machine communication. This framework rejects exclusive assignment of communicative roles (sender, message, channel, receiver) to traditionally held agents and instead focuses on evaluating agents according to their functions as a means for considering what roles are held in communication processes. As a first step in advancing this agent-agnostic perspective, this theoretical paper offers three potential criteria that both humans and machines could satisfy: agency, interactivity, and influence. Future research should extend our agent-agnostic framework to ensure that communication theory will be prepared to deal with an ostensibly machine-inclusive future.receiving of messages (Gunkel, 2012). In turn, early human-computer interaction studies took up the dynamics of software and hardware-from hypertext to peripherals-as efficient tools for users' activities (Myers, 1998). Despite the centrality of human goals and influences to human-computer interaction, technologists often consider humans only in terms of their actions (Kaptelinin, 2012). That is, users present "human problems, " both in reference to the problems that humans face and solve through technology (Blomqvist, 2018, para. 3) and in reference to how humans create problems to which technology must be resilient (Kletz, 1982, p. 209).Arguably, one of the simplest but most foundational frameworks for understanding communication as a dyadic process is the transmission model of communication (Shannon & Weaver, 1949), in which sources create messages that are then encoded into signals sent over channels (through some degree of noise) then decoded for consumption by receivers. Taken in terms of this model, scholarship within communication disciplines often characterizes machines merely as channels, and scholarship within the technological disciplines tends to characterize humans merely as senders or receivers. The parceling out of human and machine roles across disciplines is part of each domain's strength in building rich understandings of those roles. However, such parceling is also each domain's weakness in that disciplinary blinders prevent important integration of theoretical and empirical work given that the boundaries of what counts as "human" and "machine" are increasingly blurred.Although some contend the transmission model is obsolete (e.g., for rigidity and linearity; Day, 2000), we argue that the model is a useful tool for approaching emerging sociotechnical phenomena. The model focuses on core communicative functions independent of agent type, and such independence is fundamental for initially catalyzing necessary integration between human-focused and technology-fo...

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“…Hydrogels are crosslinked polymer networks with very high water content, biocompatibility, and fascinating stimuli‐responsive properties, and are promising for applications in tissue engineering, soft actuators, controlled drug release, and so on. However, conventional hydrogels usually exhibit poor mechanical strength and low stretchability, due to the lack of efficient energy dissipation mechanisms .…”

Section: Introductionmentioning

confidence: 99%

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

Gao

et al. 2019

J Polym Sci B Polym Phys

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Previous studies on hydrogels crosslinked by acrylated PEO99–PPO65–PEO99 triblock copolymer (F127DA) micelles demonstrate outstanding strength and toughness, which is attributed to the efficient energy dissipation through the hydrophobic association in the micelles. The current study further focuses on how the solvent property affects the structures and the mechanical properties of F127DA micelle crosslinked polyacrylamide gels. Binary solvents comprised of dimethyl sulfoxide (DMSO) and water are used to adjust the polymer/solvent interactions, which consequently tune the conformations of the polymer chains in the network. The presence of DMSO significantly decreases the strength but increased the stretchability of the gels, whereas the overall tensile toughness remained unchanged. In situ small‐angle X‐ray scattering measurements reveal the deformation of micelles along with the stretching direction. A structure evolution mechanism upon solvent change is proposed, according to the experimental observations, to explain influence of solvent quality on the mechanical properties of the micelle‐crosslinked gels. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 473–483

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Biohybrid robot powered by an antagonistic pair of skeletal muscle tissues

Cited by 203 publications

References 32 publications

3D Bioprinting in Skeletal Muscle Tissue Engineering

3D Bioprinting in Skeletal Muscle Tissue Engineering

Toward an Agent-Agnostic Transmission Model: Synthesizing Anthropocentric and Technocentric Paradigms in Communication

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

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