Bioglasses for Bone Tissue Engineering

Daskalakis, Evangelos; Liu, Fengyuan; Cooper, Glen M.; Weightman, Andrew; Koç, Bahattin; Blunn, Gordon; Bártolo, Paulo

doi:10.1007/978-3-030-35876-1_9

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…The basis for the classification of bioactive glass ceramics is the type of crystalline phases present in them and the resulting applications. The most known and commercially available glass-crystalline materials on the medical market include (Daskalakis et al, 2021): apatite materials for prosthetic phalanges, apatite-wollastonite (A+W) materials for endoprostheses coatings, apatite materials with mica for ear implants and orthopedic implants, apatite-free ceramics for disc-shaped implants, orbital implants, middle ear ossicles implants, and powders and coatings in dentistry. Other glass-ceramic materials that are currently used: apatite-mullite, kanansite-apatite, rananite, calciumpyrophosphate, k-fluorichterite and alkali-free (Montazerian and Zanotto, 2016).…”

Section: Fig 2 Diagram Of Reactions Occurring On the Surface Of Glass...mentioning

confidence: 99%

Glass and Glass-Ceramic Porous Materials for Biomedical Applications

Kędzia,

Lubas,

Dudek

2023

System Safety: Human - Technical Facility - Environment

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Biosilicate glasses and glass-ceramic materials obtained on their basis are an important research area in tissue engineering due to their ability to regenerate bones. The most important features of bioactive glasses include: the ability to biodegrade and high bioactivity. Appropriate porosity, pore size, surface structure and topography, chemical composition and ion release kinetics, as well as mechanical properties enable the adhesion of mesenchymal cells and their differentiation towards osteoblast cells and stimulate further proliferation and angiogenesis. This study concerns the subject of bioglass, in particular Bioglass 45S5 and glass-crystalline porous materials in the context of their properties enabling the reconstruction of bone tissue and possible applications. The article addresses crucial issues of shaping the properties of glass and glasscrystalline porous structures by introducing changes in their composition and the method of their production, and also discusses the importance of foaming agents.

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Section: Fig 2 Diagram Of Reactions Occurring On the Surface Of Glass...mentioning

confidence: 99%

Glass and Glass-Ceramic Porous Materials for Biomedical Applications

Kędzia,

Lubas,

Dudek

2023

System Safety: Human - Technical Facility - Environment

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“…Modern tissue engineering strategies rely on the use of additive manufacturing with biocompatible and biodegradable materials, living cells and growth factors to create constructs to restore, repair, and improve the function of damaged tissues and/or organs [ 1 , 2 , 3 ]. There are two commonly used strategies, cell-laden and scaffold-based approaches [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Geometry-Based Computational Fluid Dynamic Model for Predicting the Biological Behavior of Bone Tissue Engineering Scaffolds

Omar

Hassan

Daskalakis

et al. 2022

JFB

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The use of biocompatible and biodegradable porous scaffolds produced via additive manufacturing is one of the most common approaches in tissue engineering. The geometric design of tissue engineering scaffolds (e.g., pore size, pore shape, and pore distribution) has a significant impact on their biological behavior. Fluid flow dynamics are important for understanding blood flow through a porous structure, as they determine the transport of nutrients and oxygen to cells and the flushing of toxic waste. The aim of this study is to investigate the impact of the scaffold architecture, pore size and distribution on its biological performance using Computational Fluid Dynamics (CFD). Different blood flow velocities (BFV) induce wall shear stresses (WSS) on cells. WSS values above 30 mPa are detrimental to their growth. In this study, two scaffold designs were considered: rectangular scaffolds with uniform square pores (300, 350, and 450 µm), and anatomically designed circular scaffolds with a bone-like structure and pore size gradient (476–979 µm). The anatomically designed scaffolds provided the best fluid flow conditions, suggesting a 24.21% improvement in the biological performance compared to the rectangular scaffolds. The numerical observations are aligned with those of previously reported biological studies.

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Tissue Regeneration Processing and Mimicking

Oktay,

Durasi

et al. 2023

Stem Cell Biology and Regenerative Medicine

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Bioglasses for Bone Tissue Engineering

Cited by 5 publications

References 64 publications

Glass and Glass-Ceramic Porous Materials for Biomedical Applications

Glass and Glass-Ceramic Porous Materials for Biomedical Applications

Geometry-Based Computational Fluid Dynamic Model for Predicting the Biological Behavior of Bone Tissue Engineering Scaffolds

Tissue Regeneration Processing and Mimicking

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