Bioglass® and resulting crystalline materials synthesized via an acetic acid-assisted sol–gel route

Siqueira, Renato Luiz; Costa, Laiza Carvalho; Schiavon, Marco A.; Castro, Denise Tornavoi de; Reis, Andréa Cândido dos; Peitl, Oscar; Zanotto, Edgar Dutra

doi:10.1007/s10971-017-4402-3

Cited by 19 publications

(4 citation statements)

References 42 publications

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“…A 45S5-like composition [(49.2)SiO 2 -(25.8)CaO- (23.3)Na 2 O-(1.7)P 2 O 5 (mol%)] has also been reported to partially crystallize after calcination [27]. Despite this, amorphous versions of this glass composition have been reported in literature through adjustments in precursor materials, processing routes, and most importantly, calcination temperatures [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Effect of sodium on bioactive sol-gel-derived borate glasses

Lepry

Smith

Nazhat

2018

Journal of Non-Crystalline Solids

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Bioactive, sol-gel derived borate glasses (SGBGs) can rapidly convert to hydroxy-carbonated apatite (HCA) in simulated body fluid (SBF). The processing conditions and compositional changes in four-component glasses have previously been investigated, yet the effect of certain elements, such as sodium, on the processing and bioactivity has not been explored. Therefore, in this study, a borate substituted Bioglass® "45S5" of the formulation (46.1)B 2 O 3 -(26.9)CaO-(24.4)Na 2 O-(2.6)P 2 O 5 ; mol %, was created as the baseline glass and the amount of sodium was incrementally decreased three times, while maintaining the ratio of the other elements, until a sodium-free, three-component composition was generated (61.0)B 2 O 3 -(35.6)CaO-(3.4)P 2 O 5 ; mol%. Decreasing sodium content altered the gelation behaviour, textural properties, and greatly influenced reactivity as measured through gravimetric changes when exposed to water vapour. Furthermore, ion release profiles corresponded with the different glass compositions, however, interestingly, sodium content had very little effect on rate of conversion to HCA in SBF, which was observed to be within 2 h, according to x-ray diffraction, attenuated total reflectance-Fourier-transform infrared spectroscopy, and scanning electron microscopy. This study aims to serve as a basis to develop more simplified SGBG systems for tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Effect of sodium on bioactive sol-gel-derived borate glasses

Lepry

Smith

Nazhat

2018

Journal of Non-Crystalline Solids

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“…[36][37][38] It was observed that the mass loss occurs at a higher temperature for BG samples prepared in FA and AA catalytic media than the BG prepared in HNO 3 catalytic media. The elimination of (CH3COO−) ion takes place around 420 o C, observed in the BG samples prepared in AA as a catalyst, 29 as shown in Figure 2 (a). Similarly, the maximum mass loss occurred in the BG sample prepared in the FA catalyst in that regime of temperature, corresponding to the removal of formate ions.…”

Section: Tga Studiesmentioning

confidence: 90%

“…20 Several reports utilize organic acids such as lactic acid, citric acid, and acetic acid instead of strong inorganic acids to boost the efficacy of sol-gel methodology further. 4,24,28,29 Lei et al reported that acetic acid catalyzed BG has faster apatite forming rates and superior specific surfaces. 30 Initially, the sol-gel synthesis route for BG has not gained much attention due to its conversion to glass-ceramics during the heat treatment procedure.…”

Section: Introductionmentioning

confidence: 99%

Variation of the properties of sol–gel synthesized bioactive glass 45S5 in organic and inorganic acid catalysts

Chakraborty

Adhikari

Saha³

2021

Mater. Adv.

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“…Each number related to these bands indicates the average number of bridging bond atoms per silicon, ranging from 0 to 4 [27]. Precisely, the Q1 band corresponds to an increase in non-bridging bonds (NBO), denoting the Si-O-X stretch, where X ′′ could represent network modifier elements like Ca, Na, or therapeutic ions such as Sr [28,29]. Upon analyzing the RAMAN spectrum, indications strongly suggest that the Q1 band around 800 cm −1 potentially relates to Sr, suggesting its incorporation within the BG structure [21].…”

Section: Raman Spectrummentioning

confidence: 99%

Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy

Aminmansour,

Gomes de Carvalho,

Medeiros Cardoso

et al. 2024

JFB

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This study aimed to develop gelatin methacryloyl (GelMA)-injectable hydrogels incorporated with 58S bioactive glass/BG-doped with strontium for vital pulp therapy applications. GelMA hydrogels containing 0% (control), 5%, 10%, and 20% BG (w/v) were prepared. Their morphological and chemical properties were evaluated by scanning electron microscopy/SEM, energy dispersive spectroscopy/EDS, and Fourier transform infrared spectroscopy/FTIR (n = 3). Their swelling capacity and degradation ratio were also measured (n = 4). Cell viability (n = 8), mineralized matrix formation, cell adhesion, and spreading (n = 6) on DPSCs were evaluated. Data were analyzed using ANOVA/post hoc tests (α = 5%). SEM and EDS characterization confirmed the incorporation of BG particles into the hydrogel matrix, showing GelMA’s (C, O) and BG’s (Si, Cl, Na, Sr) chemical elements. FTIR revealed the main chemical groups of GelMA and BG, as ~1000 cm−1 corresponds to Si-O and ~1440 cm−1 to C-H. All the formulations were degraded by day 12, with a lower degradation ratio observed for GelMA+BG20%. Increasing the concentration of BG resulted in a lower mass swelling ratio. Biologically, all the groups were compatible with cells (p > 0.6196), and cell adhesion increased over time, irrespective of BG concentration, indicating great biocompatibility. GelMA+BG5% demonstrated a higher deposition of mineral nodules over 21 days (p < 0.0001), evidencing the osteogenic potential of hydrogels. GelMA hydrogels incorporated with BG present great cytocompatibility, support cell adhesion, and have a clinically relevant degradation profile and suitable mineralization potential, supporting their therapeutic potential as promising biomaterials for pulp capping.

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Bioglass® and resulting crystalline materials synthesized via an acetic acid-assisted sol–gel route

Cited by 19 publications

References 42 publications

Effect of sodium on bioactive sol-gel-derived borate glasses

Effect of sodium on bioactive sol-gel-derived borate glasses

Variation of the properties of sol–gel synthesized bioactive glass 45S5 in organic and inorganic acid catalysts

Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy

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