Biogenic silver nanoparticles synthesized via Mimusops elengi fruit extract, a study on antibiofilm, antibacterial, and anticancer activities

Korkmaz, Nesrin; Ceylan, Yusuf; Hamid, Attia; Karadağ, Ahmet; Bülbül, Ali Savaş; Aftab, Muhammad Nauman; Çevik, Özge; Şen, Fatih

doi:10.1016/j.jddst.2020.101864

Cited by 60 publications

(17 citation statements)

References 31 publications

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“…Overall, the obtained trends in biofilm formation suggest that FAs hold a great potential to inhibit or disrupt biofilm formation against several microbial pathogens, including S. aureus [ 42 ], P. aeruginosa [ 43 ] and C. albicans [ 39 , 44 ]. Beyond the proven antibacterial and antibiofilm track record of AgNPs [ 45 , 46 , 47 ], a variety of FAs have earlier been warranted as potential antimicrobial agent. For instance, study of Santhakumari et al [ 48 ] demonstrated hexadecanoic acid (100 µg/mL) could interrupted the QS by loosening of biofilm architecture (>60%) of vibrios spp.…”

Section: Resultsmentioning

confidence: 99%

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

et al. 2021

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The current study demonstrates the synthesis of fatty acids (FAs) capped silver nanoparticles (AgNPs) using aqueous poly-herbal drug Liv52 extract (PLE) as a reducing, dispersing and stabilizing agent. The NPs were characterized by various techniques and used to investigate their potent antibacterial, antibiofilm, antifungal and anticancer activities. GC-MS analysis of PLE shows a total of 37 peaks for a variety of bio-actives compounds. Amongst them, n-hexadecanoic acid (21.95%), linoleic acid (20.45%), oleic acid (18.01%) and stearic acid (13.99%) were found predominately and most likely acted as reducing, stabilizing and encapsulation FAs in LIV-AgNPs formation. FTIR analysis of LIV-AgNPs shows some other functional bio-actives like proteins, sugars and alkenes in the soft PLE corona. The zone of inhibition was 10.0 ± 2.2–18.5 ± 1.0 mm, 10.5 ± 2.5–22.5 ± 1.5 mm and 13.7 ± 1.0–16.5 ± 1.2 against P. aeruginosa, S. aureus and C. albicans, respectively. LIV-AgNPs inhibit biofilm formation in a dose-dependent manner i.e., 54.4% ± 3.1%—10.12% ± 2.3% (S. aureus), 72.7% ± 2.2%–23.3% ± 5.2% (P. aeruginosa) and 85.4% ± 3.3%–25.6% ± 2.2% (C. albicans), and SEM analysis of treated planktonic cells and their biofilm biomass validated the fitness of LIV-AgNPs in future nanoantibiotics. In addition, as prepared FAs rich PLE capped AgNPs have also exhibited significant (p < 0.05 *) antiproliferative activity against cultured HCT-116 cells. Overall, this is a very first demonstration on employment of FAs rich PLE for the synthesis of highly dispersible, stable and uniform sized AgNPs and their antibacterial, antifungal, antibiofilm and anticancer efficacy.

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Section: Resultsmentioning

confidence: 99%

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

et al. 2021

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“…Nanotechnology involves the adaptation of atomic materials at the nanometer level to achieve the desired shape and properties according to the field of application (1). Recently, there has been an increase in studies aimed at developing rapid, inexpensive, and environmentally friendly methods in nanoparticle synthesis methods (2).…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Green Synthesis of Ag, Ag2O, and Ag2O3 Nanoparticles

Korkmaz

Karadağ

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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In this study, nanoparticles containing Ag, Ag2O, and Ag2O3 mixture were synthesized by using a microwave-assisted green synthesis method. For the reduction of Ag + to Ag 0 , Rhododendron ponticum plant extract was used while the microwave synthesis method was used for the formation of silver oxides. Nanoparticles synthesized under 90 °C, 450 W, and 30-minute microwave synthesis conditions were characterized by UV-Vis, XRD, and STEM. As a result of characterization, Ag-NPs were found to show maximum absorbance peak at 432 nm in the UV-Vis spectrum, crystallite size was 46 nm according to XRD analysis, and nanoparticles showed in a spherical homogeneous distribution by STEM analysis. Our results showed that the phytochemicals in the plant extract of R. ponticum reduce Ag + ions to Ag-NPs and that the mixture of silver and silver oxide can be synthesized quickly and easily with microwave heating support. This study is important to increase the use of Ag2O and Ag2O3 nanoparticles in industrial production and medical applications. In particular, nanoparticles of silver and silver(I) oxide show great promise for widespread usage in medical polymers and nanodrugs. Because in this study, toxic chemicals were not used in the synthesis of silver oxide nanoparticles and it is a safe synthesis because there is no risk of explosion.

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“…Still, the most reliable results were obtained when using ethanolic extracts (instead of aqueous) on the colon adenocarcinoma cell line [256]. Complementary results on the anticancer efficiency were reported for nanosilver obtained with bulletwood fruits extract [257]. AgNPs biosynthesized by freshwater cyanobacterium potentiated the antibacterial effects of commercial antibiotics in the case of combined administration.…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 76%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Biogenic silver nanoparticles synthesized via Mimusops elengi fruit extract, a study on antibiofilm, antibacterial, and anticancer activities

Cited by 60 publications

References 31 publications

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

Microwave Assisted Green Synthesis of Ag, Ag2O, and Ag2O3 Nanoparticles

An Updated Review on Silver Nanoparticles in Biomedicine

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