Biogenic selenium nanoparticles target chronic toxoplasmosis with minimal cytotoxicity in a mouse model

Keyhani, Amir; Ziaali, Naser; Shakibaie, Mojtaba; Kareshk, Amir Tavakoli; Shojaee, Saeedeh; Asadi-Shekaari, Majid; Sepahvand, Maryam; Mahmoudvand, Hossein

doi:10.1099/jmm.0.001111

Cited by 37 publications

(13 citation statements)

References 34 publications

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“…Interestingly, the antibacterial action of SeNPs is also independent of selenoprotein synthesis and could be associated with the production of ROS (Sakr et al ., 2018). Indeed, nano-Se was shown to have antimicrobial activities against Trichophyton rubrum (Yip et al ., 2014), Candida albicans (Kheradmand et al ., 2014), Pseudomonas aeruginosa, Proteus mirabilis (Shakibaie et al ., 2015), Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli O157:H7, Salmonella Typhimurium, S. Enteritidis (Khiralla and El-Deeb, 2015), S. aureus (Nguyen et al ., 2017), and Toxoplasma gondii (Keyhani et al ., 2020). Interestingly, nano-Se is more effective than sodium selenite with regard to its anti-coccidial, anti-oxidant, and anti-inflammatory role against coccidiosis induced in the jejunum of mice (Alkhudhayri et al ., 2018).…”

Section: Discussionmentioning

confidence: 99%

Food for thought: nano-selenium in poultry nutrition and health

Surai

Kochish

2020

Anim. Health. Res. Rev.

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In recent years, nanoparticles have become a fashionable subject of research due to their sizes, shapes, and unique intrinsic physicochemical properties. In particular for the last 5 years, nano-Se has received tremendous attention in terms of its production, characteristic, and possible application for poultry/animal science and medical sciences. Indeed, Nano-Se is shown to be a potential source of Se for poultry/animal nutrition. However, there is an urgent need to address the questions related to nano-Se absorption, assimilation, and metabolism. It is not clear at present if major biological effects of nano-Se are due to Se-protein synthesis, direct antioxidant/prooxidant effects, or both. It is necessary to understand how metallic nano-Se can be converted into H2Se and further to SeCys to be incorporated into selenoproteins. The aforementioned issues must be resolved before nano-Se finds its way to animal/poultry production as a feed supplement and clearly this subject warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Food for thought: nano-selenium in poultry nutrition and health

Surai

Kochish

2020

Anim. Health. Res. Rev.

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“…Thereby, it was proposed that the stimulation of the immune system was the main therapeutic effect by which the SeNPs induce their antiparasitic activity. [ 215 ]…”

Section: Senps For Pharmaceutical Applicationsmentioning

confidence: 99%

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

198

117

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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“…Furthermore, Dkhil et al demonstrated the protective roles of Se NPs in mice infected with Schistosoma mansoni, indicating that Se NPs could possess therapeutic anti-schistosomal activity in the treatment of intestinal schistosomiasis (Dkhil et al, 2019). Additionally, biogenic Se NPs were also found to show anti-Toxoplasma effects against Toxoplasma gondii in mice with no considerable toxicity, demonstrating the therapeutic effects of Se NPs for toxoplasmosis in vivo (Keyhani et al, 2020a;Keyhani et al, 2020b;Shakibaie et al, 2020). These in vivo findings along with the previously mentioned in vitro results collectively demonstrated that Se NPs could be served as nutritional supplements with powerful anti-parasite effects.…”

Section: Anti-parasite Effects Of Selenium Nanoparticlesmentioning

confidence: 99%

The Advancing of Selenium Nanoparticles Against Infectious Diseases

Lin

Zhang

et al. 2021

Front. Pharmacol.

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Infectious diseases, caused by the direct exposure of cellular or acellular pathogens, are found to be closely associated with multiple inflammation and immune responses, keeping one of the top threats to human health. As an indispensable trace element, Selenium (Se) plays important roles in antioxidant defence and redox state regulation along with a variety of specific metabolic pathways. In recent decades, with the development of novel nanotechnology, Selenium nanoparticles (Se NPs) emerged as a promising agent for biomedical uses due to their low toxicity, degradability and high bioavailability. Taking the advantages of the strong ability to trigger apoptosis or autophagy by regulating reactive oxygen species (ROS), Se NPs have been widely used for direct anticancer treatments and pathogen killing/clearance in host cells. With excellent stability and drug encapsulation capacity, Se NPs are now serving as a kind of powerful nano-carriers for anti-cancer, anti-inflammation and anti-infection treatments. Notably, Se NPs are also found to play critical roles in immunity regulations, such as macrophage and T effector cell activation, which thus provides new possibilities to achieve novel nano-immune synergetic strategy for anti-cancer and anti-infection therapies. In this review, we summarized the progress of preparation methods for Se NPs, followed by the advances of their biological functions and mechanisms for biomedical uses, especially in the field of anti-infection treatments. Moreover, we further provide some prospects of Se NPs in anti-infectious diseases, which would be helpful for facilitating their future research progress for anti-infection therapy.

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Biogenic selenium nanoparticles target chronic toxoplasmosis with minimal cytotoxicity in a mouse model

Cited by 37 publications

References 34 publications

Food for thought: nano-selenium in poultry nutrition and health

Food for thought: nano-selenium in poultry nutrition and health

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

The Advancing of Selenium Nanoparticles Against Infectious Diseases

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