Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent

Aygün, Ayşenur; Gülbağça, Fulya; Ozer, Lütfiye Yıldız; Ustaoglu, Buket; Altunoğlu, Yasemin Çelik; Baloğlu, Mehmet Cengiz; Atalar, Mehmet Nuri; Alma, Mehmet Hakkı; Şen, Fatih

doi:10.1016/j.jpba.2019.112961

Cited by 127 publications

(48 citation statements)

References 50 publications

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“…Furthermore, the reason for using nanoparticles for disease therapy depends on their structure and dimension compared to the conventional small-molecule medicines [ 6 , 7 , 8 ]. Amongst the metal nanoparticles, silver nanoparticles (AgNPs) are a good candidate for infection control owing to their contact with the mitochondrial respiratory chain, which shows compatibility and bioavailability toward the treatment of various persistent illnesses, including cancer [ 9 , 10 , 11 ]. In addition, AgNPs have the advantage of disrupting mitochondrial function with the aid of prompting the generation of reactive oxygen species and the advantage of facilitating the preparation of ATP [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

Gudikandula

Srileka

Charya

et al. 2021

Heliyon

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Silver nanoparticles (AgNPs) were successfully synthesized using silver nitrate via the biological route using the culture filtrate of Ganoderma enigmaticum as well as Trametes ljubarskyi white rot fungi materials at room temperature. The proposed synthetic technique was applied for the first time for AgNPs preparation via the biological route through a low-cost pathway, which considered as an adequate direction of preparation compared to the commercial methods. This study reports the in vitro cytotoxic effect of biologically synthesized AgNPs in disposing of the human lung cancer cell line (A549) and human breast cancer cell (MCF-7) by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. In addition, the viability of the tested cell lines was tested after treatment for 24 h in the presence of the prepared nanoparticles. The obtained results indicated the reduced viability of cancer cell lines with improving concentrations of AgNPs (40–120 μg/mL) at 24 h. Furthermore, at 120 μg/mL concentration, the fungal nanoparticles showed substantial cytotoxic effects toward the treated cells. Consequently, the results designated that the biologically synthesized silver nanoparticles have effective behavior for treating A549 and MCF-7 cancer cells from the laboratory experiment approach; however, additional studies are required to validate these results in vivo models as anticancer agents depending on their cytotoxic activity.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

Gudikandula

Srileka

Charya

et al. 2021

Heliyon

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“…30 Advances in nanotechnology have allowed for development of MNPs that can be used for detection, prevention, and inhibition of cancer with low toxicity against normal cells. 3 Aygun et al 31 showed that after treatment MDA-MB-231 and HeLa cancer cells with Pt NPs, a significant cellular growth inhibition was observed. Bin-Meferij et al 32 showed that SNPs synthesized using Nostoc sp.…”

Section: Introductionmentioning

confidence: 99%

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

117

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Background: The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial activity, and do not suffer from the limitations inherent in physiochemical synthesis methods. Methodology: In this study, we isolated, purified, and characterized a novel cyanobacteria extract (Desertifilum IPPAS B-1220) to utilize in biofabrication of silver nanoparticles (D-SNPs). D-SNPs were produced by adding Desertifilum extract to silver nitrate solution under controlled conditions. Biofabrication of D-SNPs was confirmed using a UV-Vis spectrophotometer. The resultant D-SNPs were characterized using XRD, FTIR, SEM, and TEM. The toxicity of D-SNPs against five pathogenic bacteria and three cancer cell lines (MCF-7, HepG2, and Caco-2) was evaluated. Results: Formation of D-SNPs was indicated by a color change from pale yellow to dark brown. The peak of the surface plasmon resonance of the D-SNPs was at 421 nm. The XRD detected the crystallinity of D-SNPs. FTIR showed that polysaccharides and proteins may have contributed to the biofabrication of D-SNPs. Under SEM and TEM, the D-SNPs were spherical with diameter ranges from 4.5 to 26 nm. The D-SNPs significantly suppressed the growth of five pathogenic bacteria, and exerted cytotoxic effects against MCF-7, HepG2, and Caco-2 cancer cells with IC 50 values of 58, 32, and 90 µg/mL, respectively. Conclusion: These findings showed for the first time the potentiality of novel cyanobacteria strain Desertifilum IPPAS B-1220 to fabricate small SNPs that acted as potent anticancer and antibacterial material against different cancer cell lines and pathogenic bacterial strains. These findings encourage the researchers to focus on cyanobacteria in general and especially Desertifilum sp. IPPAS B-1220 for synthesizing different NPs that opening the window for new applications.

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“…Ultrasonic nano-emulsion formulation of the essential oil of Nigella sativa also exhibits anti-cancer activity as it induces apoptosis in MCF-7 cells [ 263 ]. Other studies have reported that biogenic platinum nanoparticles made using black cumin seed ( Nigella sativa L. ) extract were cytotoxic to MDA-MB-231 breast cells [ 264 ] and silver nanoparticles made from an aqueous seed extract of Nigella sativa induce apoptosis in MCF-7 cells by altering the expression of apoptotic proteins such as Bcl-2 and Bax and an inflammatory marker such as COX-2 [ 265 ].…”

Section: Black Cumin ( Nigella Sativa )mentioning

confidence: 99%

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

et al. 2020

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Background: Breast cancer is one of the principal causes of death among women and there is a pressing need to develop novel and effective anti-cancer agents. Natural plant products have shown promising results as anti-cancer agents. Their effectiveness is reported as decreased toxicity in usage, along with safety and less recurrent resistances compared with hormonal targeting anti-cancer agents. Methods: A literature search was conducted for all English-language literature published prior to June 2020. The search was conducted using electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library. The search strategy included keywords such as breast cancer, herbs, anti-cancer biologically active components, clinical research, chemotherapy drugs amongst others. Results: The literature provides documented evidence of the chemo-preventative and chemotherapeutic properties of Ginseng, garlic (Allium sativum), Black cohosh (Actaea racemose), Tumeric (Curcuma longa), Camellia sinenis (green tea), Echinacea, Arctium (burdock), Flaxseed (Linum usitatissimum) and Black Cumin (Nigella sativa). Conclusions: The nine herbs displayed anti-cancer properties and their outcomes and mechanisms of action include inhibition of cell proliferation, angiogenesis and apoptosis as well as modulation of key intracellular pathways. However, more clinical trials and cohort human studies should be conducted to provide key evidence of their medical benefits.

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Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent

Cited by 127 publications

References 50 publications

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

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