Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer

Singh, Neelu; Das, Monoj Kumar; Ansari, Aftab A.; Mohanta, Dambarudhar; Rajamani, Paulraj

doi:10.1016/j.btre.2021.e00612

Cited by 14 publications

(3 citation statements)

References 46 publications

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“…The bandgap energy estimated using Tauc plot ( Equation 1 ) was found to be 4.65 eV ( Figure S6 ), which is close to values reported from other biosynthesized gold nanoparticles. 19 …”

Section: Resultsmentioning

confidence: 99%

Biosynthesis of highly branched gold nanoparticles through structural engineering of fatty acids

Yue¹,

Yokota²,

Uchihashi³

2023

iScience

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“…The bandgap energy estimated using Tauc plot ( Equation 1 ) was found to be 4.65 eV ( Figure S6 ), which is close to values reported from other biosynthesized gold nanoparticles. 19 …”

Section: Resultsmentioning

confidence: 99%

Biosynthesis of highly branched gold nanoparticles through structural engineering of fatty acids

Yue¹,

Yokota²,

Uchihashi³

2023

iScience

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“…Similarly, gold NPs (Au-NPs) are gold particles of nanosized range (1-100 nm) which are being used in many studies as carriers for delivering anticancer agents of natural origin (Singh et al, 2021). In one such study, Au-NPs of Nerium oleander were prepared, characterized and anticancer potential was tested against MCF-7 cells.…”

Section: Nanomaterials From Natural Moleculesmentioning

confidence: 99%

A review of nanomaterials from synthetic and natural molecules for prospective breast cancer nanotherapy

et al. 2023

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Breast cancer being one of the most frequent cancers in women accounts for almost a quarter of all cancer cases. Early and late-stage breast cancer outcomes have improved dramatically, with considerable gains in overall survival rate and disease-free state. However, the current therapy of breast cancer suffers from drug resistance leading to relapse and recurrence of the disease. Also, the currently used synthetic and natural agents have bioavailability issues which limit their use. Recently, nanocarriers-assisted delivery of synthetic and natural anticancer drugs has been introduced to the breast cancer therapy which alienates the limitations associated with the current therapy to a great extent. Significant progress has lately been made in the realm of nanotechnology, which proved to be vital in the fight against drug resistance. Nanotechnology has been successfully applied in the effective and improved therapy of different forms of breast cancer including invasive, non-invasive as well as triple negative breast cancer (TNBC), etc. This review presents a comprehensive overview of various nanoformulations prepared for the improved delivery of synthetic and natural anticancer drugs alone or in combination showing better efficacy and pharmacokinetics. In addition to this, various ongoing and completed clinical studies and patents granted on nanotechnology-based breast cancer drug delivery are also reviewed.

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“…Green synthesized AuNPs have been tested mostly against MCF-7 cancer cell line, and various ways in which AuNPs have interacted with MCF-7 cells have been reported, including alteration of the integrity of cell membranes, oxidative stress, interrupting physiological as well as metabolic processes, severing synthesis of ATP, halting the transfer of electrons, and finally, shrinking of cells and apoptosis [ 143 , 144 , 145 ]. Results of the study conducted by Devendiran et al [ 146 ] unveil the prodigious potential of AuNPs as carriers of chemotherapy drugs in drug delivery systems.…”

Section: Green Synthesis Of Aunps For Cancer Theranosticsmentioning

confidence: 99%

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

Sargazi

Laraib

et al. 2022

Nanomaterials

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Nanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.

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Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer

Abstract: Graphical abstract

Cited by 14 publications

References 46 publications

Biosynthesis of highly branched gold nanoparticles through structural engineering of fatty acids

Biosynthesis of highly branched gold nanoparticles through structural engineering of fatty acids

A review of nanomaterials from synthetic and natural molecules for prospective breast cancer nanotherapy

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

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