Biogenic monoamines in developing taste buds of mouse circumvallate papillae.

Takeda, Masako; Shishido, Yoko; Kitao, Kenji

doi:10.1679/aohc1950.44.485

Cited by 27 publications

(18 citation statements)

References 17 publications

(11 reference statements)

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“…The major difference is that this so-called piriform chemosensory cell has synapselike groupings of vesicles in the cytoplasm adjacent to intragemmal nerve processes (Id6 and Munger, 1980;Zahm and Munger, 1983 The type 111 cell of adult rabbit foliate papillae is generally considered a receptor cell, mostly because the groups of vesicles oppo-site nerve processes resemble synaptic vesicles (Murray et al, 1969;Murray, 1971Murray, , 1973Murray and Murray, 1971;Sangiacomo, 1970;Hirata, 1975, 1976;Takeda, 1977;Takeda et al, 1981;Fujimoto, 1982). Our results in the monkey are in substantial agreement with findings in the rabbit.…”

Section: Discussionmentioning

confidence: 99%

“…Our results in the monkey are in substantial agreement with findings in the rabbit. The results of recent investigations in the rabbit have suggested that at least some of these vesicles contain serotonin, a potential neurotransmitter (Fujimoto, 1982; see also Nada and Hirata, 1975;Takeda, 1977;Takeda et al, 1981). The larger of these vesicles have also been compared to Merkel cell vesicles, on the basis of their size and orientation to intraepithelial nerve processes (Ciges et al, 1976;Ide and Munger, 1980).…”

Section: Discussionmentioning

confidence: 99%

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Structure of taste buds in foliate papillae of the rhesus monkey, Macaca mulatta

Farbman¹,

Hellekant

Nelson³

1985

Am. J. Anat.

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Taste buds in foliate papillae of the rhesus monkey were examined by electron microscopy. Three distinct cell types were identified. Type I cells were narrow elongated cells containing an oval nucleus, bundles of intermediate filaments, several Golgi bodies, and characteristic apical membrane-bounded dense granules. These cells exhibited morphological variations: some had a moderately dense cytoplasm, perinuclear free ribosomes, and flattened sacs of rough endoplasmic reticulum; others had a more lucent cytoplasm, dilated irregular rough endoplasmic reticulum, lysosome-like dense bodies, and lipid droplets. Type II cells typically contained a spherical, pale nucleus, a prominent nucleolus, supranuclear and infranuclear Golgi bodies, mitochondria with tubular cristae, and one or two centrioles. This cell type, too, showed some variation in the relative amounts of ribosomes and smooth endoplasmic reticulum, which varied inversely with each other. Type III cells were characterized by a clear apical cytoplasm essentially devoid of ribosomes and containing microtubules. In a few type III cells, the peri- and infranuclear regions contained many ribosomes and some rough endoplasmic reticulum. In most Type III cells, there were large numbers of dense and clear vesicles in the peri- and infranuclear regions; some of the vesicles were grouped in synapse-like arrangements with adjacent nerves. The morphological variations exhibited by all three cell types could be accounted for by age differences in each of the cells. This would be consistent with the notion that cell renewal occurs in each of the three cell populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Structure of taste buds in foliate papillae of the rhesus monkey, Macaca mulatta

Farbman¹,

Hellekant

Nelson³

1985

Am. J. Anat.

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“…Further, Type III cells in rabbits exhibit serotonin-like immunoreactivity (Nada and Komatsu, 1983;Nagai et al, 1998). Following Murray's description of Type III taste cells in rabbit foliate taste buds and despite large interspecies differences in taste cell ultrastructure, this terminology was applied to other mammals, including the mouse (Takeda, 1976;1977;Takeda and Kitao, 1980;Takeda et al, 1981), rat (Takeda and Hoshino, 1975), monkey (Farbman et al, 1985), and guinea pig (Yoshie et al, 1990). In rabbits, Type III cells have several defining characteristics including: an elongate spindle shape, basal synapses, a single blunt apical extension, DCV, and an electronlucent cytoplasm when preparations are fixed in glutaraldehyde.…”

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confidence: 99%

“…In rabbits, Type III cells have several defining characteristics including: an elongate spindle shape, basal synapses, a single blunt apical extension, DCV, and an electronlucent cytoplasm when preparations are fixed in glutaraldehyde. In the mouse, the term "Type III" cell has been applied to taste cells exhibiting one or only a few of these key features, e.g., a long spindle shape, the ability to concentrate monoamines, or the presence of DCV or synapses (Takeda, 1976(Takeda, , 1977Takeda and Kitao, 1980;Takeda et al, 1981). Complicating the situation further, in mouse taste buds, both electron-lucent (light) and electron-dense (dark) taste cells have been reported to form synapses with nerve processes (Kinnamon et al, 1985;Royer and Kinnamon, 1988).…”

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confidence: 99%

“Type III” cells of rat taste buds: Immunohistochemical and ultrastructural studies of neuron‐specific enolase, protein gene product 9.5, and serotonin

Yee

Yang

Böttger

et al. 2001

J of Comparative Neurology

240

269

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Taste buds contain a variety of morphological and histochemical types of elongate cells. Serotonin, neuron-specific enolase (NSE), ubiquitin carboxyl terminal hydrolase (PGP 9.5), and neural cell adhesion molecule (N-CAM) all have been described as being present in the morphologically defined Type III taste cells in rats. In order to determine whether these substances coexist in a single cell, we undertook immunohistochemical and ultrastructural analysis of taste buds in rats. Double-label studies show that PGP 9.5 and NSE always colocalize. In contrast, PGP 9.5 and serotonin seldom colocalize. Further, whereas the serotonin-immunoreactive cells are always slender and elongate, the PGP 9.5/NSE population comprise two morphological types--one slender, the other broader and pyriform. Although gustducin-immunoreactive taste cells appear similar in overall shape to the pyriform PGP 9.5/NSE population, gustducin never colocalizes with PGP 9.5 or NSE. The serotonin-immunoreactive taste cells have an invaginated nucleus, synaptic contacts with nerve fibers, and taper apically to a single, large microvillus. These are all characteristics of Type III taste cells described previously in rabbits (Murray [1973] Ultrastructure of Sensory Organs I. Amsterdam: North Holland. p 1-81). PGP 9.5-immunoreactive taste cells exhibit two morphological varieties. One type is similar to the serotonin-immunoreactive population, containing an invaginated nucleus, synapses with nerve fibers, and a single large microvillus. The other type of PGP 9.5-immunoreactive taste cell has a large round nucleus and the apical end of the cell tapers to a tuft of short microvilli, which are characteristics of Type II taste cells. Thus, in rats, some Type III cells accumulate serotonin but do not express PGP 9.5, whereas others express PGP 9.5 but do not accumulate amines. Similarly, Type II taste cells come in at least two varieties: those immunoreactive for gustducin and those immunoreactive for PGP 9.5.

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“…Taste receptor cells turn over with an average life span of about 10 days in mammals (1)(2)(3). The replacement of receptor cells is accompanied by continuing synaptic reconnection between newly formed taste cells and first-order gustatory fibers.…”

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confidence: 99%

Reinnervation of cross-regenerated gustatory nerve fibers into amiloride-sensitive and amiloride-insensitive taste receptor cells

Ninomiya

1998

Proc. Natl. Acad. Sci. U.S.A.

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Single nerve fiber responses to NaCl and their inhibition by amiloride were compared among the chorda tympani (CT) and glossopharyngeal (IXth), and their cross-regenerated nerves in the C57BL͞KsJ mice. The CT nerve innervating the anterior part of the tongue contained approximately equal numbers of two types of NaCl-responsive neurons; one type showed strong suppression of NaCl responses by amiloride [amiloride-sensitive (AS) type], and the other type showed only weak or no suppression of NaCl responses by amiloride [amiloride-insensitive (AI) type]. In contrast, the IXth nerve innervating the posterior part of the tongue has almost exclusively the AI type. This relative abundance of the AS and AI types of fibers was not altered by cross-regeneration of the two gustatory nerves into the reverse tongue regions. This suggests that regenerated taste axons selectively recouple with the appropriate type of receptor cell whether they innervate the front or the back of the tongue. Such selective synapse reformation may help explain the stability of response profiles of taste neurons during continual receptor cell turnover.Taste receptor cells turn over with an average life span of about 10 days in mammals (1-3). The replacement of receptor cells is accompanied by continuing synaptic reconnection between newly formed taste cells and first-order gustatory fibers. Little is known about how a stable sensory code for taste quality is maintained under such continual synaptic reconnection. More than 20 years ago it was observed (4) that branches of a single taste fiber have very similar relative responsiveness to taste stimuli, implying that a given class of taste axons maintains a persistent association with its corresponding class of receptor cells. However, since then little additional evidence for this possibility has been reported. This may largely be because of the lack of a selective taste modifier to identify particular taste receptor types that taste axons innervate.Recently, it was found in many mammals that a sodium transport blocker, amiloride, specifically inhibits taste responses to NaCl, but does not suppress responses to sweet, sour, and bitter substances (5-7). Using this specific NaCl response inhibitor, subsequent neural response analyses in rodents suggested the existence of two subtypes of receptor mechanisms for NaCl: amiloride-sensitive and amilorideinsensitive. These two subtypes were localized in taste buds in fungiform papillae located on the anterior two-thirds of the tongue, which are innervated by the chorda tympani (CT) nerve (8-10). In marked contrast, it was also reported that in C57BL͞KsJ mice (11) and SHR and WKY rats (12) the taste buds in vallate and foliate papillae located on the posterior one-third of the tongue, innervated by the glossopharyngeal (IXth) nerve, may lack the amiloride-sensitive subtype.It has been shown that transection of the gustatory nerves (the CT and IXth nerves) results in degeneration of taste buds within 7 days, and the taste buds reappear after regenerati...

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Biogenic monoamines in developing taste buds of mouse circumvallate papillae.

Cited by 27 publications

References 17 publications

Structure of taste buds in foliate papillae of the rhesus monkey, Macaca mulatta

Structure of taste buds in foliate papillae of the rhesus monkey, Macaca mulatta

“Type III” cells of rat taste buds: Immunohistochemical and ultrastructural studies of neuron‐specific enolase, protein gene product 9.5, and serotonin

Reinnervation of cross-regenerated gustatory nerve fibers into amiloride-sensitive and amiloride-insensitive taste receptor cells

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