Abstract:Lysosomes, the major degradative compartments of the cell acquire unique properties upon receiving external signals. In the skin, epidermal keratinocytes follow a gradual differentiation process from the basal to the upper skin layers with consequent changes in cellular morphology and intracellular organelles. Previous studies show that keratinocyte differentiation relies on increased lysosome biogenesis. However, the mechanisms of the generation and maintenance of keratinocyte lysosomes remain unknown. Here, … Show more
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