Biogenesis of peroxisomes in fetal liver

Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor α (PPARα)

“…In human fetal liver single catalase positive particles, presumably peroxisomes, become first visible in the 7th week of gestation [58] resembling those in HepG2 cells at 5 days in culture. In later stages of gestation (18-23 weeks) human hepatocytes show a marked heterogeneity in the distribution of peroxisomes with many cells containing clusters of often more than six spherical to angular particles resembling those in differentiated HepG2 cells, exhibiting a heterogeneous DAB-staining for catalase [17]. This heterogeneity in both peroxisomal distribution and staining intensity is still retained in adult hepatocytes [47,58].…”

Peroxisome Mosaics in the Liver of Patients and the Regulation of Peroxisome Expression in Rat Hepatocyte Culturesa

“…The peroxisomal forms seen after 6 days of culture in monolayer, as well as in the sandwich gel configuration, are strongly reminiscent of the peroxisomes in human duodenal epitheli~m?~ as well as the peroxisomes of quail oocytes. 16 Hepatocytes and intestinal epithelium have the same embryological origin from the primitive gut endo-FIGURE 8. Rat hepatocyte grown for 6 days between two layers of rat tail collagen.…”

The Impact of a Ketogenic Diet and Liver Dysfunction on Serum Very Long‐Chain Fatty Acids Levels

“…Group comparison were performed using ANOVA Kruskal-Wallis test. P value versus control VLCFA very long-chain fatty acid, C22:0 docosanoic acid, C24:0 tetracosanoic acid, C26:0 hexacosanoic acid, X-ALD/AMN X-linked adrenoleukodystrophy/adrenomyeloneuropathy, n numbers of subjects * Source [13] Lipids (2013) 48:405-409 407 these organelles display heterogeneity in their enzyme activity even within the same cell, depending on the development stage and environment [16,17]. The VLCFA are degraded exclusively by the peroxisomal b-oxidation process.…”

“…Peroxisomes are already present in foetal liver at 6 weeks. Their number increases during development by *40 times [16]. Cytochemical investigations have shown that in human livers, Table 1 Serum VLCFA levels in patients on a ketogenic diet, with liver dysfunction, peroxisomal disorders, and controls Patients (n) Values are presented as means ± SD.…”