Biogenesis of Lysergic Acid in Ergot

Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul

“…These results were expected in the light of other work (Groger et al, 1960;Taylor & Ramstad, 1960;Birch et al, 1960;Vining & Taber, 1963;Agurell, 1966;Majer et al, 1967;Castagnoli et al, 1970) the lysergic acid moiety of ergotamine is similar to that found for the other ergot alkaloids.…”

“…However, it has been demonstrated that the same ergoline precursors, namely tryptophan and indole (Paul, 1957;Baxter et al, 1960Baxter et al, , 1961Taber & Vining, 1959;Vining & Taber, 1963;Groger & Erge, 1970), mevalonic acid (Baxter (I) Ergotamine et al, 1961;Taylor & Ramstad, 1960) and the methyl group of L-methionine (Majer et al, 1967;Castagnoli et al, 1970), function as specific precursors for the lysergic acid moiety of the peptide alkaloids.…”

Biosynthesis of the Ergot Alkaloids

“…Additional evidence for the function of mevalonic acid as an ergot alkaloid precursor was obtained by Taylor and Ramstad (34). Meva-Ionic a~id-2-C'~ was added to the growth medium of a strain of Claviceps (PRL 1578) which produced small quantities of lysergic acid-derived ergot alkaloids in saprophytic culture.…”

Biosynthesis of Ergot Alkaloids

“…All atoms retained , Pleininger et al 1961, Arcamone et al 1962 14 j3-mevalonic acid incorporated and becomes C-17 of ergoline derivatives. Birch, McLaughlin, Smith 1960, Groger et al 1960Taylor and Ramstad ) 1960;Baxter et al 1962 Mevalonic acid incorporated as One unit. ( Birch et al, 1960;Bhattacharji et Floss and Grtigey963; Pyke, 1964: Pleininger, Immel andV81k1)1967).…”