Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy

Zhu, Tianqi; Jiang, Mengyang; Zhang, Mingran; Cui, Liguo; Xiao-pu, Yang; Wang, Xukai; Liu, Guangyao; Ding, Jianxun; Chen, Xuesi

doi:10.1016/j.bioactmat.2021.08.005

Cited by 74 publications

(72 citation statements)

References 48 publications

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“…A number of organic [for example, poly(lactide-co-glycolide) (PLGA), poly(ε-caprolactone), polylactide and chitosan], inorganic (for example, nano-hydroxyapatite, β-tricalcium phosphate and ceramics) and composite materials have attracted increasing attention as the matrix of bone tissue engineering scaffolds. This is due to their excellent biocompatibility, controllable degradation, easy processing, excellent mechanical properties, osteoconductivity and the ability to promote bone regeneration (127)(128)(129)(130). The combined application of polymers and various other substances utilizes the advantages of various substances and the advantages of polymers to meet the needs of a wider range of osteonecrosis research.…”

Section: Porous Tantalum or Other Implants Transplantationmentioning

confidence: 99%

Treatment of non‑traumatic avascular necrosis of the femoral head (Review)

et al. 2022

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Non-traumatic osteonecrosis of the femoral head is the main cause of disability in young individuals and incurs major health care expenditure. The lifestyle changes in recent years, especially increased use of hormones and alcohol consumption, has greatly increased the incidence of femoral head necrosis. The underlying causes and risk factors of osteonecrosis of the femoral head are increasingly being elucidated, which has led to the development of novel surgical and non-surgical treatment options. Although the main goal of any treatment method is prevention and delaying the progression of disease, there is no common consensus on the most suitable method of treatment. The present review discussed the latest developments in the etiology and treatment methods for femoral head necrosis. Contents 1. Introduction 2. Epidemiology 3. Pathogenesis 4. Treatment strategies 5. Conclusion

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Section: Porous Tantalum or Other Implants Transplantationmentioning

confidence: 99%

Treatment of non‑traumatic avascular necrosis of the femoral head (Review)

et al. 2022

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“…Although these emerging therapies have produced impressive results, clinical treatment of patients with bone tumors requires consideration of both the complete removal of all tumor cells and the bone defects caused by the surgery [ 8 ]. Researchers have provided several routes to solve the problem of bone defects [ [22] , [23] , [24] , [25] ], one of which is the use of bioactive scaffolds [ [26] , [27] , [28] ]. The clinical standards for bone grafting are autografts, which are considered the “gold standard” for bone repair and allografts.…”

Section: Introductionmentioning

confidence: 99%

Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Yuan

Zeng

et al. 2022

Materials Today Bio

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“…High-dose GCs can inhibit the Wnt/β-catenin pathway by upregulating the expression of DKK-1, which prevents the differentiation of BMSCs into osteoblasts and induces adipogenesis ( Kato et al, 2018 ; Zhun et al, 2018 ). In recent years, biomaterials that promote osteogenesis have made great progress in the treatment of ONFH ( Zhao and Ma, 2020 ; Zhu et al, 2020 ; Zhu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Copper-Lithium-Doped Nanohydroxyapatite Modulates Mesenchymal Stem Cells Homing to Treat Glucocorticoids-Related Osteonecrosis of the Femoral Head

Yang

Wei

et al. 2022

Front. Bioeng. Biotechnol.

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In situ tissue regeneration has been demonstrated to promote bone repair. To identify a better approach for treating osteonecrosis of the femoral head (ONFH), we prepared scaffolds using copper-lithium-doped nanohydroxyapatite (Cu-Li-nHA), which has the potential to modulate mesenchymal stem cells (MSCs) homing. The scaffold was fabricated using the gas foaming method and the migration, angiogenesis, and osteogenesis activities of MSCs were detected using Transwell assays, tube formation assays, alkaline phosphatase and alizarin red S staining, respectively. We then implanted the Cu-Li-nHA scaffold into the femoral heads of ONFH rabbits, and CFSE labeled exogenous MSCs were injected intravenously to verify cell homing. The repair effect was subsequently examined using micro-CT and histological analysis in vivo. The results showed that Cu-Li-nHA significantly promoted MSCs migration and homing by upregulating the HIF-1α/SDF-1 pathway. The Cu-Li-nHA group showed optimal osteogenesis and angiogenesis and greater improvements in new bone formation in ONFH rabbits. To summarize, Cu-Li-nHA promoted homing and induced the osteogenic differentiation of MSCs, thereby enhancing bone regeneration during ONFH repair. Thus, Cu-Li-nHA implantation may serve as a potential therapeutic strategy for ONFH in the future.

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Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy

Cited by 74 publications

References 48 publications

Treatment of non‑traumatic avascular necrosis of the femoral head (Review)

Treatment of non‑traumatic avascular necrosis of the femoral head (Review)

Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Copper-Lithium-Doped Nanohydroxyapatite Modulates Mesenchymal Stem Cells Homing to Treat Glucocorticoids-Related Osteonecrosis of the Femoral Head

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