Biofunctionalization of graphene and its two-dimensional analogues and synthesis of biomimetic materials: a review

Di, Shuhan; Qian, Yuhong; Wang, Li; Li, Zhuang

doi:10.1007/s10853-021-06787-0

Cited by 10 publications

(7 citation statements)

References 151 publications

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“…These biomolecules may mimic the charged proteins in the extracellular matrix that regulate bone formation by improving attractions between the graphene surface and mineral ions [77] . Graphene materials are surface functionalized with polydopamine (PDA), [50] chitosan, [78] peptide, [79] carrageenan, [80] casein phosphopeptide, [81] fibrinogen [82] . The biomineralization results in the generation of homogeneous nanocomposites having flake‐like HA [83] .…”

Section: Literature Reportsmentioning

confidence: 99%

A Comprehensive Review on Novel Graphene‐Hydroxyapatite Nanocomposites For Potential Bioimplant Applications

et al. 2023

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The advancements in medical treatment necessitated the development of advanced bio-implant materials for hard tissue replacement and bone regeneration. Hydroxyapatite (HA), an extreme bioresorbable material having physicochemical similarities with natural bone, seems to be a good bioimplant. Still, the ineffective mechanical properties, viz. fracture toughness, wear resistance, and tensile strength, restrict its practical utility in bioimplants. Recently, graphene-HA nanocomposites have been explored for potential bioimplant applications ascribed to their superior biocompatibility, bioactivity, osteoconductivity, and enhanced mechanical properties. The huge surface area with a two-dimensional sheet structure facilitates graphene's strong integration with HA, thus enhancing mechanical properties. These enhanced mechanical properties of graphene-HA nanocomposite are chiefly attributed to the pull-out, ridge growth, crack deflection, and grain bridging characteristics exhibited by graphene filler in the HA matrix. Further, graphene is neutral and biocompatible, thus improving the graphene-HA nanocomposite's biocompatibility. These qualities made this nanocomposite a rising star among bio-ceramic implant materials. This review presents the current scenario on the synthesis and mechanical and biological properties of graphene-hydroxyapatite nanocomposite, which seems to be a propitious material for implants in orthopaedic applications.

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Section: Literature Reportsmentioning

confidence: 99%

A Comprehensive Review on Novel Graphene‐Hydroxyapatite Nanocomposites For Potential Bioimplant Applications

et al. 2023

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“…have attracted the attention of researchers because of their unique layered structure and excellent mechanical/chemical properties. [4][5][6] For example, in 2020, our group demonstrated adsorbents with sh-scale morphology that made its adsorption capacity against targets much higher than that of granular adsorbents because of the increased contact area of adsorbents with targets. 7 Asefa's group investigated the adsorption behaviours of dendritic silica and cylindrical pore mesoporous silica on DNA.…”

Section: Introductionmentioning

confidence: 99%

Room temperature synthesis of flower-like hollow covalent organic framework for efficient enrichment of microcystins

Chen

Zhang

et al. 2023

RSC Adv.

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“…Nanomaterials based on graphene, like GO, have improved biomedical applications including drug delivery, hydrogel scaffolds, fibers, and so forth . GO provides active surfaces for drug loading through several kinds of interactions such as covalent cross-linking, electrostatic interactions, and physical absorption such as π–π stacking, which are all used to load the drug . Usually, the surface of GO is crowded by huge numbers of carboxyl, hydroxyl, or epoxy functionalities that could be exploited for common chemical reactions such as acylation, diazotization, or covalent modification of these functional groups .…”

Section: Introductionmentioning

confidence: 99%

PEGylated Graphene Oxide as a Nanodrug Delivery Vehicle for Podophyllotoxin (GO/PEG/PTOX) and In Vitro α-Amylase/α-Glucosidase Inhibition Activities

Islam

Khan

et al. 2023

ACS Omega

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This study aims to develop a nanodrug delivery system containing podophyllotoxin (PTOX), a known anticancer drug, loaded on graphene oxide (GO). The system’s ability to inhibit α-amylase and α-glucosidase enzymes was also investigated. PTOX was isolated from Podophyllum hexandrum roots with a yield of 2.3%. GO, prepared by Hummer’s method, was converted into GO-COOH and surface-mobilized using polyethylene glycol (PEG) (1:1) in an aqueous medium to obtain GO-PEG. PTOX was loaded on GO-PEG in a facile manner with a 25% loading ratio. All the samples were characterized using FT-IR spectroscopy, UV/visible spectroscopy, and scanning electron microscopy (SEM). In FT-IR spectral data, GO-PEG-PTOX exhibited a reduction in acidic functionalities and there was an appearance of the ester linkage of PTOX with GO. The UV/visible measurements suggested an increase of absorbance in 290–350 nm regions for GO-PEG, suggesting the successful drug loading on its surface (25%). GO-PEG-PTOX exhibited a rough, aggregated, and scattered type of pattern in SEM with distinct edges and binding of PTOX on its surface. GO-PEG-PTOX remained potent in inhibiting both α-amylase and α-glucosidase with IC50 values of 7 and 5 mg/mL, closer to the IC50 of pure PTOX (5 and 4.5 mg/mL), respectively. Owing to the 25% loading ratio and 50% release within 48 h, our results are much more promising. Additionally, the molecular docking studies confirmed four types of interactions between the active centers of enzymes and PTOX, thus supporting the experimental results. In conclusion, the PTOX-loaded GO nanocomposites are promising α-amylase- and α-glucosidase-inhibitory agents when applied in vitro and have been reported for the first time.

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Biofunctionalization of graphene and its two-dimensional analogues and synthesis of biomimetic materials: a review

Cited by 10 publications

References 151 publications

A Comprehensive Review on Novel Graphene‐Hydroxyapatite Nanocomposites For Potential Bioimplant Applications

A Comprehensive Review on Novel Graphene‐Hydroxyapatite Nanocomposites For Potential Bioimplant Applications

Room temperature synthesis of flower-like hollow covalent organic framework for efficient enrichment of microcystins

PEGylated Graphene Oxide as a Nanodrug Delivery Vehicle for Podophyllotoxin (GO/PEG/PTOX) and In Vitro α-Amylase/α-Glucosidase Inhibition Activities

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