Biofunctional porous anodized titanium implants for enhanced bone regeneration

Shim, In Kyong; Chung, Hye Jin; Jung, Mi; Nam, Seung Yeon; Lee, Su Young; Lee, Hyukjin; Heo, Seong‐Joo; Lee, Seung Jin

doi:10.1002/jbm.a.35026

Cited by 43 publications

(28 citation statements)

References 31 publications

(73 reference statements)

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“…Cho et al (2011) demonstrated the surfaces coated with 1,25-dihydroxyvitamin D 3 -loaded PLGA particles via electrospray can promote osseointegration of anodized titanium implants. Shim et al (2013) showed anodized Ti discs partially coated with fibroblast growth factor-2 (FGF-2)-loaded PLGA nanoparticles by electrospray deposition. The coating retained their original porous structure and simultaneously exhibited a continuous release of FGF-2 for 2 weeks.…”

Section: Applicationsmentioning

confidence: 99%

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Xie

Jiang

Davoodi

et al. 2015

Chemical Engineering Science

261

159

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Electrohydrodynamic atomization (EHDA), also called electrospray technique, has been studied for more than one century. However, since 1990s it has begun to be used to produce and process micro-/nanostructured materials. Owing to the simplicity and flexibility in EHDA experimental setup, it has been successfully employed to generate particulate materials with controllable compositions, structures, sizes, morphologies, and shapes. EHDA has also been used to deposit micro- and nanoparticulate materials on surfaces in a well-controlled manner. All these attributes make EHDA a fascinating tool for preparing and assembling a wide range of micro- and nanostructured materials which have been exploited for use in pharmaceutics, food, and healthcare to name a few. Our goal is to review this field, which allows scientists and engineers to learn about the EHDA technique and how it might be used to create, process, and assemble micro-/nanoparticulate materials with unique and intriguing properties. We begin with a brief introduction to the mechanism and setup of EHDA technique. We then discuss issues critical to successful application of EHDA technique, including control of composition, size, shape, morphology, structure of particulate materials and their assembly. We also illustrate a few of the many potential applications of particulate materials, especially in the area of drug delivery and regenerative medicine. Next, we review the simulation and modeling of Taylor cone-jet formation for a single and co-axial nozzle. The mathematical modeling of particle transport and deposition is presented to provide a deeper understanding of the effective parameters in the preparation, collection and pattering processes. We conclude this article with a discussion on perspectives and future possibilities in this field.

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Section: Applicationsmentioning

confidence: 99%

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Xie

Jiang

Davoodi

et al. 2015

Chemical Engineering Science

261

159

View full text Add to dashboard Cite

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“…The family of growth factors is widely applied to stimulate cell growth and differentiation of primary and progenitor cells to osteoblasts or endothelial cells (Park et al, 2010;Zieris et al, 2010). Other cellular events that favor implant healing and integration, such as increased collagen synthesis or enhanced cell adhesion and proliferation, were also induced by growth factors Shim et al, 2014). In particular, bone morphogenetic protein-2 (BMP-2), which belongs to the transforming growth factor β (TGF-β) superfamily, is applied in the field of dental and orthopedic implants because of its strong osteoinductive effect (Migliorini et al, 2016).…”

Section: Components Of Multifunctional Biomaterials Coatingsmentioning

confidence: 99%

Multifunctional biomaterial coatings: synthetic challenges and biological activity

Pagel

Beck‐Sickinger

2017

Biological Chemistry

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A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of various combinations of bioactive, and bioinert components as well as of reporter molecules to improve cell-material contacts, prevent infections or to analyze biochemical events on the surface. However, specific immobilization and particular assembly of various active molecules are challenging. Herein, an overview of multifunctional coatings for biomaterials is given, focusing on synthetic strategies and the biological benefits by displaying several motifs.

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“…Es wurde sowohl eine Stimulation der Knochenbildung an der Implantatoberfläche (für eine Beschichtung aus PGLA/bFGF-Nanopartikeln [108,109]) als auch eine Steigerung der Adhä-sion, Proliferation und Differenzierung von humanen Gingivafibroblasten (für eine Beschichtung aus Kollagen/HA mit RGD-Peptid [110]) gezeigt. Unklar bleibt, ob dieser Unterschied auf dem Design des Experiments, der Immobilisierungsmethode oder den sehr verschiedenen Trägerbeschichtun-gen beruht.…”

Section: Andere Wachstumsfaktoren (Pdgf Vegf Bfgf)unclassified