Biofluid Mechanics of the Pulmonary System

Bertram, Christopher; Gaver, Donald P.

doi:10.1007/s10439-005-8758-0

Cited by 26 publications

(17 citation statements)

References 105 publications

(85 reference statements)

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“…This gradient induces a convective Marangoni flow outward from the region of deposition. Induced Marangoni flow has potential use in improving drug delivery in patients with obstructive pulmonary conditions such as cystic fibrosis lung disease, where accumulation of dehydrated mucus alters airway aerodynamics and subsequent patterns of aerosol deposition in the lung (for examples, see references [5–7]).…”

Section: Introductionmentioning

confidence: 99%

Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions

Stetten

Moraca

Corcoran

et al. 2016

Journal of Colloid and Interface Science

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It has long been known that deposited drops of surfactant solution induce Marangoni flows at air-liquid interfaces. These surfactant drops create a surface tension gradient, which causes an outward flow at the fluid interface. We show that aqueous phospholipid dispersions may be used for this same purpose. In aqueous dispersions, phospholipids aggregate into vesicles that are not surface-active; therefore, drops of these dispersions do not initiate Marangoni flow. However, aerosolization of these dispersions disrupts the vesicles, allowing access to the surface-active monomers within. These lipid monomers do have the ability to induce Marangoni flow. We hypothesize that monomers released from broken vesicles adsorb on the surfaces of individual aerosol droplets and then create localized surface tension reduction upon droplet deposition. Deposition of lipid monomers via aerosolization produces surface tensions as low as 1 mN/m on water. In addition, aerosolized lipid deposition also drives Marangoni flow on entangled polymer solution subphases with low initial surface tensions (~ 34 mN/m.) The fact that aerosolization of phospholipids naturally found within pulmonary surfactant can drive Marangoni flows on low surface tension liquids suggests that aerosolized lipids may be used to promote uniform pulmonary drug delivery without the need for exogenous spreading agents.

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Section: Introductionmentioning

confidence: 99%

Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions

Stetten

Moraca

Corcoran

et al. 2016

Journal of Colloid and Interface Science

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“…Biomedical examples of flow involving collapsible tubes are mainly in the circulatory and respiratory systems. Some examples include arteries [2], veins [3], urethras, vocal cords and pulmonary airways [4].…”

Section: Introductionmentioning

confidence: 99%

Effects of downstream system on self‐excited oscillations in collapsible tubes

Wang

Chew

Low

2009

Commun. Numer. Meth. Engng.

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SUMMARYDuring self-excited oscillation, the effects of downstream head, resistance and inertia on the amplitude and frequency of the tube outlet pressure and flow have been studied experimentally. Different sets of resistance and head combinations could be arranged to achieve identical mean pressure-flow condition, but the unsteady pressure and flow waveforms were found to be different. In a conventional experimental set-up, the direct effect of downstream resistance could be inadvertently complicated by the indirect ones, which were caused by the associated variations of mean pressure and flow on the downstream head.

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“…In parallel with advances in solid mechanics, ongoing investigations of biofluid mechanics in the pulmonary system (Bertram and Gaver 2005) are providing an improved understanding of lung injury mechanisms associated with closure and opening of fragile tissue structures (Kay et al 2004; Yalcin et al 2007), and generating multi-scale models for investigation of fluid dynamics in airways and lung vasculature (Tawhai and Burrowes 2008). At the interface of solid and fluid surfaces, recent experimental work has demonstrated that the airway-lining layer of mucus, which is optimized for lung defense and clearance, is responsive to airway shear stresses (Tarran et al 2005; Tarran et al 2006), and that pathological changes in mucus viscoelasticity can be targeted as a new therapeutic modality for patients with cystic fibrosis (Donaldson et al 2006; Tarran et al 2007).…”

Section: Micro-scale and Multi-scale Mechanicsmentioning

confidence: 99%

Recent advances and new opportunities in lung mechanobiology

Tschumperlin¹,

Boudreault²,

Liu³

2010

Journal of Biomechanics

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Lung function is inextricably linked to mechanics. On short timescales every breath generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the airways and vasculature. Perturbations such airway smooth muscle shortening or surfactant dysfunction rapidly alter respiratory mechanics, with profound influence on lung function. On longer timescales, lung development, maturation, and remodeling all strongly depend on cues from the mechanical environment. Thus mechanics has long played a central role in our developing understanding of lung biology and respiratory physiology. This concise review focuses on progress over the past five years in elucidating the molecular origins of lung mechanical behavior, and the cellular signaling events triggered by mechanical perturbations that contribute to lung development, homeostasis, and injury. Special emphasis is placed on the tools and approaches opening new avenues for investigation of lung behavior at integrative cellular and molecular scales. We conclude with a brief summary of selected opportunities and challenges that lie ahead for the lung mechanobiology research community.

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Biofluid Mechanics of the Pulmonary System

Cited by 26 publications

References 105 publications

Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions

Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions

Effects of downstream system on self‐excited oscillations in collapsible tubes

Recent advances and new opportunities in lung mechanobiology

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