Biofluid 1H NMR-based metabonomic techniques in nutrition research — metabolic effects of dietary isoflavones in humans

Solanky, Kirty S.; Bailey, Nigel J.; Beckwith-Hall, Bridgette M.; Bingham, Sheila; Davis, Adrienne L.; Holmes, Elaine; Nicholson, Jeremy K.; Cassidy, Aedín

doi:10.1016/j.jnutbio.2004.12.005

Cited by 146 publications

(137 citation statements)

References 23 publications

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“…Increased excretion of TMAO has been reported after consumption of fish (45) and diets with high salt content (31). It has also been found that menstruation may lead to a significant reduction in the TMAO/trimethylamine ratio in female urine (46).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the influence of physiological variation in the urine metabolic pattern of healthy human subjects using NMR-based metabonomic techniques, providing information on factors that exhibit notable variation (29)(30)(31)(32)(33). Lenz and coworkers (29) studied the intra-and inter-subject variability of the plasma and urine metabolic profiles of 12 healthy male subjects and evaluated the influence of the timing of the collection of the urine sample.…”

Section: Introductionmentioning

confidence: 99%

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Gender‐related and age‐related urinalysis of healthy subjects by NMR‐based metabonomics

Psihogios¹,

Gazi²,

Elisaf³

et al. 2007

NMR in Biomedicine

137

139

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NMR-based metabonomic analysis is a well-established approach to characterizing healthy and diseased states. The aim of this study was to investigate inter-individual variability in the metabolic urinary profile of a healthy Greek population, not subjected to strict dietary limitations, by NMR-based metabonomics. The overall metabonomic urinalysis showed a homogeneous distribution among the population. The metabolic profile was examined in relation to gender and age, and reference intervals of major metabolites were determined. Multivariate data analysis led to the construction of two robust models that were able to predict the class membership of the subjects studied according to their gender and age. The most influential low molecular weight metabolites responsible for the differences in gender groups were citrate, creatinine, trimethylamine N-oxide, glycine, creatine and taurine, and for the differences in age groups they were citrate, creatinine, trimethylamine N-oxide and an unidentified metabolite (d 3.78).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender‐related and age‐related urinalysis of healthy subjects by NMR‐based metabonomics

Psihogios¹,

Gazi²,

Elisaf³

et al. 2007

NMR in Biomedicine

137

139

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show abstract

“…Examples would be the effect of meat and fish consumption on the risk of colorectal cancer, metabolic differences in the intake of green and black tea or the metabolic effects of dietary isoflavones in humans [4][5][6][7][8][9][10][11]. However, directly associating genes or lifestyle habits with clinical endpoints provides only limited information about the underlying disease-causing mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics

et al. 2010

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“…These fingerprints can be interpreted and classified according to disease status by using multivariate statistical analysis (13). Although metabonomics has been successfully used in many fields, e.g., in the study of disease processes (14,15) and dietary intervention (16,17), the application of this technology to characterize parasitic diseases is still in its infancy.…”

mentioning

confidence: 99%

Global metabolic responses of mice to Trypanosoma brucei brucei infection

Wang

Utzinger²,

Saric

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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124

185

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Human African trypanosomiasis (HAT) is transmitted by tsetse flies and, if untreated, is fatal. Treatment depends on infection stage, and early diagnosis is crucial for effective disease management. The systemic host biochemical changes induced by HAT that enable biomarker discovery or relate to therapeutic outcome are largely unknown. We have characterized the multivariate temporal responses of mice to Trypanosoma brucei brucei infection, using 1 H nuclear magnetic resonance (NMR) spectroscopic metabolic phenotyping of urine and plasma. Marked alterations in plasma metabolic profiles were detected already 1 day postinfection. Elevated plasma concentrations of lactate, branched chain amino acids, and acetylglycoprotein fragments were noted. T. brucei brucei-infected mice also had an imbalance of plasma alanine and valine, consistent with differential gluconeogenesis (parasite)-ketogenesis (host) pathway counterflux, involving stimulated host glycolysis, ketogenesis, and enhanced lipid oxidation in the host. Histopathologic evidence of T. brucei brucei-induced extramedullary hepatic hemopoiesis, renal interstitial nephritis, and a provoked inflammatory response was also noted. Metabolic disturbance of gut microbiotal activity was associated with infection, as indicated by changes in the urinary concentrations of the microbial co-metabolites, including hippurate. Concluding, parasite infection results in multiple systemic biochemical effects in the host and disturbance of the symbiotic gut microbial metabolic interactions. Investigation of these transgenomic metabolic alterations may underpin the development of new diagnostic criteria and metrics of therapeutic efficacy. diagnosis ͉ metabonomics ͉ NMR spectroscopy ͉ trypanosomiasis

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Biofluid 1H NMR-based metabonomic techniques in nutrition research — metabolic effects of dietary isoflavones in humans

Cited by 146 publications

References 23 publications

Gender‐related and age‐related urinalysis of healthy subjects by NMR‐based metabonomics

Gender‐related and age‐related urinalysis of healthy subjects by NMR‐based metabonomics

Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics

Global metabolic responses of mice to Trypanosoma brucei brucei infection

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