Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia–reperfusion injury: an experimental study

Huk, I.; Brovkovych, Viktor; Vili, J. Nanobash; Weigel, Günter; Neumayer, Ch.; Partyka, Łukasz; Patton, Stephen R.; Maliński, Tadeusz

doi:10.1046/j.1365-2168.1998.00787.x

Cited by 135 publications

(88 citation statements)

References 22 publications

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“…Estudos in vitro têm mostrado que a quercetina e outros flavonóides inibem fortemente a produção de Óxido Nítrico e do Fator de Necrose Tumoral pelas células de Kupffer quando estimuladas pela injúria 8 . A quercetina combate com eficiência os ânions superóxido na isquemiareperfusão 9 . Os efeitos da quercetina e de outros flavonóides na doença hepática não estão bem elucidados.…”

Section: Resultsunclassified

Uso de quercetina a longo prazo em ratos cirróticos

Miltersteiner

Filho

et al. 2003

Acta Cir. Bras.

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Section: Resultsunclassified

Uso de quercetina a longo prazo em ratos cirróticos

Miltersteiner

Filho

et al. 2003

Acta Cir. Bras.

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“…In a previous study, it has been demonstrated that quercetin has protective effects against IR damage by increasing SOD, CAT, GPx activities in heart 82 . Also, in another study, the increase of the SOD activity has been reported after quercetin treatment 86,89 . Protective effect of quercetin on experimental chronic cadmium nephrotoxicity on rats has been evaluated and increase of the SOD activity by the quercetin has been detected 87 .…”

Section: Resultsmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg À1 dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.

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“…During the inflammatory process, the proinflammatory mediators, such as NO, COX-2 and proinflammatory cytokines, are rapidly produced in large amount (Posadas et al, 2000). NO is required in immunological defense mechanisms and maintaining the dilation of blood vessels (Huk et al, 1998). Higher concentration of NO can cause oxidative damage, which is involved in various pathological processes (Stichtenoth and Frolich, 1998;Weinberg, 1998;Nagy and Perl, 2006).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-inflammatory Activities and Mechanisms of Microalga Phaeodactylum tricornutum

Kim¹,

Kim²,

Pan³

et al. 2013

Journal of Applied Biological Chemistry

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Due to their diversity and abundancy, marine resources have emerged as important biological resources to compensate the limited sources of terrestrial biological materials. Phaeodactylum tricornutum (PT) is one of classical model diatoms most widely studied for its ecology, physiology, biochemistry and molecular biology. In this study, four different PT extracts on lipopolysaccharide (LPS)-stimulated macrophages were compared for anti-inflammatory effect and investigated for the underlying mechanisms. The extracts of PT inhibited nitric oxide production from LPS stimulated RAW 264.7 cells in a dose dependent manner. These extracts also inhibited the expression of mRNA and production of proteins of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α. These inhibitory effects were found to be caused by blockage of nuclear factor-κB activation and phosphorylation of p38 mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2 and c-Jun N-terminal kinase.

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Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia–reperfusion injury: an experimental study

Abstract: Quercetin treatment mollified ischaemia-reperfusion injury to skeletal muscle by scavenging destructive superoxide and enhancing the cytoprotective nitric oxide concentration.

Cited by 135 publications

References 22 publications

Uso de quercetina a longo prazo em ratos cirróticos

Uso de quercetina a longo prazo em ratos cirróticos

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Evaluation of Anti-inflammatory Activities and Mechanisms of Microalga Phaeodactylum tricornutum

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