Biofilms: the matrix revisited

Branda, Steven S.; Vik, Åshild; Friedman, Lisa; Kolter, Roberto

doi:10.1016/j.tim.2004.11.006

Cited by 1,518 publications

(1,248 citation statements)

References 60 publications

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“…to solid surfaces has important applications in DNA microarrays, [678][679][680] gene therapy, 681,682 DNA-based devices, 683,684 high quality DNA purification by chromatographic techniques, 685,686 and DNA hybridization. 687,688 The initial stage of biofilm formation is facilitated by the attachment of extracellular DNA on the substrate surface 689 so that a thorough understanding of DNA adsorption to surfaces is of great relevance to control the formation of bacterial biofilms.…”

Section: Interaction With Nucleic Acid-related Biomoleculesmentioning

confidence: 99%

Silica Surface Features and Their Role in the Adsorption of Biomolecules: Computational Modeling and Experiments

et al. 2013

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Section: Interaction With Nucleic Acid-related Biomoleculesmentioning

confidence: 99%

Silica Surface Features and Their Role in the Adsorption of Biomolecules: Computational Modeling and Experiments

et al. 2013

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“…My introduction to this perspective was recognizing organized patterns of differential action in colonies (Shapiro, 1984b, c). A related major focus of contemporary bacterial studies is the actions of biofilms, which are thin colonies spread over a surface (Stoodley et al, 2002;Webb et al, 2003;Parsek & Fuqua, 2004;Branda et al, 2005). It is now widely recognized that multicellularity provides important advantages for pathogens in initial colonization and protection again host defenses (Costerton et al, 1999;Davies, 2003).…”

Section: Bacteria As Masters Of Cell-cell Interactionsmentioning

confidence: 99%

Bacteria are small but not stupid: cognition, natural genetic engineering and socio-bacteriology

Shapiro

2007

Studies in History and Philosophy of Science Part C: Studies in

170

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40 years experience as a bacterial geneticist have taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the 20 th Century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell-cell signaling, symbiosis and pathogenesis show that bacteria utilize sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of "higher" plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognize that even the smallest cells are sentient beings.

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“…Although these phenotypes were stable on plates and in liquid cultures, they exhibited a transient behavior when cultivated as a biofilm so that irrespective of the inoculum type a similar ratio of the two was established within a few days. Morphological divergence is a common feature in biofilm populations and has been studied by several groups (Bantinaki et al, 2007;Branda et al, 2005;Drenkard and Ausubel, 2002;Sauer et al, 2002;Spiers et al, 2002).…”

Section: Discussion Dynamic Equilibrium Of Microbial Phenotype Composmentioning

confidence: 99%

“…Morphological changes include many different forms of biofilm architecture and depend on sometimes small changes in environmental conditions such as different agar concentrations (Branda et al, 2005), or changes in the hydrophobicity of the substratum (Dalton et al, 1994).…”

Section: Discussion Dynamic Equilibrium Of Microbial Phenotype Composmentioning

confidence: 99%

Characterization of a biofilm membrane reactor and its prospects for fine chemical synthesis

Gross

Lang

Bühler

et al. 2009

Biotech & Bioengineering

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Biofilms are known to be robust biocatalysts. Conventionally, they have been mainly applied for wastewater treatment, however recent reports about their employment for chemical synthesis are increasingly attracting attention. Engineered Pseudomonas sp. strain VLB120DC biofilm growing in a tubular membrane reactor was utilized for the continuous production of (S)-styrene oxide. A biofilm specific morphotype appeared in the effluent during cultivation, accounting for 60-80% of the total biofilm irrespective of inoculation conditions but with similar specific activities as the original morphotype. Mass transfer of the substrate styrene and the product styrene oxide was found to be dependent on the flow rate but was not limiting the epoxidation rate. Oxygen was identified as one of the main parameters influencing the biotransformation rate. Productivity was linearly dependent on the specific membrane area and on the tube wall thickness. On average volumetric productivities of 24 g L À1 aq day À1 with a maximum of 70 g L À1 aq day À1 and biomass concentrations of 45 g BDW L À1 aq have been achieved over long continuous process periods (!50 days) without reactor downtimes.

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Biofilms: the matrix revisited

Cited by 1,518 publications

References 60 publications

Silica Surface Features and Their Role in the Adsorption of Biomolecules: Computational Modeling and Experiments

Silica Surface Features and Their Role in the Adsorption of Biomolecules: Computational Modeling and Experiments

Bacteria are small but not stupid: cognition, natural genetic engineering and socio-bacteriology

Characterization of a biofilm membrane reactor and its prospects for fine chemical synthesis

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