Biofilms in chronic rhinosinusitis: systematic review and suggestions for future research

Keir, Jeff; Pedelty, Lee; Swift, A. C.

doi:10.1017/s0022215111000016

Cited by 34 publications

(41 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The discrepancy may be attributed to different detection methods, as well as the influence of impact factors of BBF. Thus, a study with elegant design is required for a definite conclusion [24]. In this study, we found BBF in 16/27 (59.26%) CRS patients and none in 10 controls using BacLight/CSLM detection.…”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Han

Wang

Sun

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The purpose of this study was to investigate the incidence of bacterial biofilm (BBF) in patients with chronic rhinosinusitis (CRS) using confocal scanning laser microscopy (CSLM), and to assess the relationship between BBF and clinical features of CRS. This was a prospective observational study of the sinus mucosa of 27 CRS patients and 10 controls undergoing endoscopic sinus surgery (ESS). Clinical information was recorded preoperatively and sinus mucosal specimens were collected intraoperatively. We determined the existence of BBF with BacLight/CSLM detection, and proposed a BBF scoring system based on its morphologic features. Clinical parameters, including symptom score, endoscopy score, CT score and symptom duration, were compared between CRS patients with and without BBF, and among CRS patients with different BBF score. BBF was found in 16/27 (59.26%) CRS patients and none in 10 controls. SNOT-20 symptom score and individual symptoms including need to blow nose, cough and postnasal discharge were significantly more severe in CRS patients with BBF than those without. BBF score was better correlated than BBF existence with SNOT-20 score (r = 0.811, P < 0.001 vs. r = 0.604, P = 0.001), and correlated with both endoscopy score (r = 0.490, P = 0.009) and symptom duration (r = 0.487, P = 0.010), neither was correlated with BBF (P = 0.824; P = 0.263). BBF score is likely to guide anti-BBF therapy in CRS patients.

show abstract

Section: Discussionmentioning

confidence: 59%

“…The discrepancy may be attributed to different detection methods, as well as the presence of determinants of BBF. Thus, a study with elegant design is required for a definite conclusion [24].…”

Section: Introductionmentioning

confidence: 99%

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Han

Wang

Sun

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…13-15 Biofilms occur frequently, but not always, in patients with CRS but also occur in healthy subjects. The most robust detection techniques require electron microscopy or fluorescent in situ hybridization.…”

Section: Pathophysiology Of Crsmentioning

confidence: 99%

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Akdiş

Bachert

Cingi

et al. 2013

Journal of Allergy and Clinical Immunology

514

403

View full text Add to dashboard Cite

Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of CRS and improving treatment. It is generally agreed that there are clinically relevant CRS phenotypes defined by an observable characteristic or trait, such as the presence or absence of nasal polyps. Defining the phenotype of the patient is useful in making therapeutic decisions. However, clinical phenotypes do not provide full insight into all underlying cellular and molecular pathophysiologic mechanisms of CRS. Recognition of the heterogeneity of CRS has promoted the concept that CRS consists of multiple groups of biological subtypes, or “endotypes,” which are defined by distinct pathophysiologic mechanisms that might be identified by corresponding biomarkers. Different CRS endotypes can be characterized by differences in responsiveness to different treatments, including topical intranasal corticosteroids and biological agents, such as anti–IL-5 and anti-IgE mAb, and can be based on different biomarkers that are linked to underlying mechanisms. CRS has been regarded as a single disease entity in clinical and genetic studies in the past, which can explain the failure to identify consistent genetic and environmental correlations. In addition, better identification of endotypes might permit individualization of therapy that can be targeted against the pathophysiologic processes of a patient's endotype, with potential for more effective treatment and better patient outcomes.

show abstract

“…Around 90 % of adults have had some symptoms of sinusitis at some time. There is a growing appreciation that chronic rhinosinusitis is typifi ed by biofi lm growth (Foreman et al 2011 ;Keir et al 2011 ;Ebbens et al 2009a ). While there is increasing evidence for the role of bacterial biofi lms in this infection, there role of fungi remains controversial (Ebbens et al 2009b ).…”

Section: Upper Airwaysmentioning

confidence: 99%

Fungal Biofilms in Human Disease

Williams

Ramage

2014

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Biofilms in chronic rhinosinusitis: systematic review and suggestions for future research

Cited by 34 publications

References 52 publications

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Fungal Biofilms in Human Disease

Contact Info

Product

Resources

About