Biofilms and host response – helpful or harmful

Abstract

host response -helpful or harmful. APMIS 2017; 125: 320-338.Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non-obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm-related infections, both foreign bodyrelated and non-foreign body-related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.

The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease

“…[52][53][54][55][56]. The presence of biofilms in these conditions can affect host cellular function and can lead to inflammation and tissue damage [56,57].…”

Host responses to mucosal biofilms in the lung and gut

“…29,63 P. aeruginosa biofilm-mediated infections in vivo are associated with leukocyte mobilization and bacterial-specific antibody production to clear the pathogen. 59,[64][65][66] Multiple studies have established that P. aeruginosa triggers a predominant Th2 immune response in the human CF lung and in murine CF models. 64,67,68 CF patients chronically infected with P. aeruginosa have higher levels of interleukin (IL)-3, IL-4, and secreted immunoglobulin A (sIgA; Th2 markers) and lower interferon gamma (IFNγ; Th1 marker), compared to non-chronically infected patients.…”

“…59,[64][65][66] Multiple studies have established that P. aeruginosa triggers a predominant Th2 immune response in the human CF lung and in murine CF models. 64,67,68 CF patients chronically infected with P. aeruginosa have higher levels of interleukin (IL)-3, IL-4, and secreted immunoglobulin A (sIgA; Th2 markers) and lower interferon gamma (IFNγ; Th1 marker), compared to non-chronically infected patients. 65,[69][70][71] Th2 responses have also been observed in vitro and in murine mouse models of CF in response to challenge with P. aeruginosa and/or its gene products.…”

Антибіоплівкова Терапія При Лікуванні Респіраторних Інфекційних Захворювань, Викликаних Бактеріальними Патогенами

“…Патогенные бактерии, достигая определенной плотности в колонизированной среде, из планктон ной формы существования переходят к оседлой или микробиосоциальной форме жизнедеятельности, формируя своеобразную структуру -биопленку, которая располагается на открытых поверхностях органов макроорганизма [21]. Биопленка представ ляет собой образование, содержащее бактерии, ко торые заключены в состоящий из полисахаридов, протеинов и экстрабактериальной ДНК экзополи мерный матрикс, который предохраняет бактерии от действия антимикробных агентов [4,14,23]. С формированием бактериальной биопленки, по мнению современных микробиологов, связано раз витие хронических воспалительных заболеваний, ассоциированных с бактериальным инфекцион ным процессом.…”