Biofilm in Chronic Sinusitis with Nasal Polyps: Pilot study

Bezerra, Thiago Freire Pinto; Pádua, Francini Grecco de Melo; Ogawa, Allex Itar; Gebrim, Eloísa Maria Mello Santiago; Saldiva, Paulo Hilário Nascimento; Voegels, Richard Louis

doi:10.1016/s1808-8694(15)30538-3

Cited by 43 publications

(10 citation statements)

References 31 publications

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“…Since its initial identification on the sinonasal mucosa of CRS patients in 2004, numerous studies have confirmed a high incidence of BBF in CRS patients [3,4,7,8,[12][13][14][15][16][17][18][19][20][21][22][23]. To date, a correlation between BBF and poor disease progression has been established, indicating its role as an important factor in this condition [3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that at least 65% of all human bacterial infections involve biofilm formation [11]. Since its initial identification on the sinonasal mucosa of CRS patients in 2004, numerous studies have confirmed a high incidence of BBF in CRS patients, indicating its role as an important factor in this condition [3,4,7,8,[12][13][14][15][16][17][18][19][20][21][22][23]. However, BBF positive rate in the previous reports varied from 20.9 to 100%.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Han

Wang

Sun

et al. 2011

Eur Arch Otorhinolaryngol

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The purpose of this study was to investigate the incidence of bacterial biofilm (BBF) in patients with chronic rhinosinusitis (CRS) using confocal scanning laser microscopy (CSLM), and to assess the relationship between BBF and clinical features of CRS. This was a prospective observational study of the sinus mucosa of 27 CRS patients and 10 controls undergoing endoscopic sinus surgery (ESS). Clinical information was recorded preoperatively and sinus mucosal specimens were collected intraoperatively. We determined the existence of BBF with BacLight/CSLM detection, and proposed a BBF scoring system based on its morphologic features. Clinical parameters, including symptom score, endoscopy score, CT score and symptom duration, were compared between CRS patients with and without BBF, and among CRS patients with different BBF score. BBF was found in 16/27 (59.26%) CRS patients and none in 10 controls. SNOT-20 symptom score and individual symptoms including need to blow nose, cough and postnasal discharge were significantly more severe in CRS patients with BBF than those without. BBF score was better correlated than BBF existence with SNOT-20 score (r = 0.811, P < 0.001 vs. r = 0.604, P = 0.001), and correlated with both endoscopy score (r = 0.490, P = 0.009) and symptom duration (r = 0.487, P = 0.010), neither was correlated with BBF (P = 0.824; P = 0.263). BBF score is likely to guide anti-BBF therapy in CRS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Han

Wang

Sun

et al. 2011

Eur Arch Otorhinolaryngol

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“…Centers for Disease Control and Prevention declared that biofilms were present in 65 % of all bacterial infections. 16 It is believed that 99% of all bacteria exist in biofilms. Only 1% lives in a free-floating state at any given time.…”

Section: Figurementioning

confidence: 99%

Presence of Biofilms in the Lacrimal Sac Mucosa

Koşarsoy¹,

Özer²,

Öǧretmenoǧlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The inflammation and the following fibrosis due to the bacterial colonization are thought to be the principle underlying mechanism in the development of nasolacrimal duct stenosis. The aim of this study was to investigate the presence of biofilms in the lacrimal sac mucosa of the patients with dacryostenosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included 15 patients with a symptom of epiphora for at least 3 months and documented dacryostenosis with a dacryocystography. Lacrimal sac mucosal specimens obtained during endoscopic dacryocystorhinostomy (DCR) were examined for the presence of biofilm formation under the scanning electron microscope. R Re es su ul lt ts s: : The specimens were obtained from 15 patients. The mean age of 12 female and 3 male patients was 54 years. Epiphora was the main symptom and its average duration was 18 (6-36) months. We could not analyze specimen in 1 patient. We detected biofilm formation in 12 of 14 (% 85.7) specimens. Biofilm formation was dense in 5 specimens and light in 7 specimens. C Co on nc cl lu us si io on n: : This is the first article that documents the presence of bacterial biofilms on the lacrimal sac mucosa in the patients with dacryostenosis. This study shows the presence of biofilms in cases with dacryostenosis and interrogates its role in the etiology of chronic dacryocystitis similar to other chronic infections. Further investigations on this subject should be carried on in larger and controlled series to assure the role of biofilms in the etiology of chronic infections. New studies should also investigate whether the biofilm formation is the reason or the result of chronic infections. We believe that, control of biofilm formation in chronic infections would prevent secondary problems like the development of dacryostenosis.K Ke ey y W Wo or rd ds s: : Biofilms; dacryocystitis; microscopy, electron, scanning; dacryocystorhinostomy Ö ÖZ ZE ET T A Am ma aç ç: : Bakteriyel kolonizasyon sonucu gelişen inflamasyon ve fibrozis, nazolakrimal kanal stenozuna yol açan temel mekanizma olarak kabul edilmektedir. Bu çalışmanın amacı, dakriostenozlu olguların lakrimal kese mukozalarında biofilm varlığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmaya en az 3 aydır epifora şikayeti olan ve dakriosistografide dakriostenoz tespit edilen 15 olgu dahil edilmiştir. Endoskopik dakriosistorinostomi sırasında elde edilen lakrimal kese mukoza örnekleri, tarayıcı elektron mikroskopide incelenerek biyofilm varlığı araştırılmıştır. B Bu ul lg gu ul la ar r: : Ortalama yaşı 54 olan 12 kadın ve 3 erkek, toplam 15 hasta çalışmaya dahil edilmiştir. Hastalarda görülen en sık semptom epifora idi ve ortalama 18 aydır mevcuttu. İncelenen 14 spesmenin 12 (%85,7)'sinde biyofilm tespit edildi. Spesmenlerin 1 tanesinin analizi yapılamadı. Biyofilm formasyonu örneklerin 5'inde hafif, 7'sinde ise yoğun idi. S So on nu uç ç: : Bu makale dakriostenozlu hastaların lakrimal kese muko...

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“…Recientes estudios han correlacionado la presencia de biofilmes con un peor pronóstico en pacientes con RSC (23)(24)(25). En estos casos, factores como la depresión, el consumo de cigarrillo, la poliposis nasal, la sensibilidad a la aspirina y el reflujo gastroesofágico influyen en su formación (10,13,26,27).…”

Section: Biofilmes Y Rinosinusitis Crónicaunclassified

Biofilmes: causa del manejo refractario de la rinosinusitis crónica

Pérez

Vásquez

Coneo

2018

Acta otorrinolaringol cir cabeza cuello

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Introducción: Aunque muchos pacientes con rinosinusitis crónica (RSC) mejoran luego del tratamiento médico o quirúrgico, existe una subpoblación que la padece y en la que se torna recalcitrante. Esta inflamación persistente es compatible con el perfil de una infección por biofilmes. Objetivos: Ha habido un interés creciente en el estudio de biofilmes como factor principal en las infecciones crónicas. El propósito de este artículo es revisar la literatura disponible sobre rinosinusitis crónica y biofilmes. Metodología: Revisión de la literatura pertinente que se obtuvo con la búsqueda selectiva de las siguientes bases de datos: Science Direct, Pubmed y Scielo. Se realizó búsqueda entre los años 2000 y 2012. Se analizaron los resúmenes y se escogieron los textos completos que trataban sobre biofilmes y rinosinusitis crónica. Resultados: Se revisaron 34 artículos completos que se ajustaban a las exigencias de los objetivos. La evidencia científica actual relaciona los biofilmes con el desarrollo y la persistencia de la enfermedad rinosinusal crónica, con la presencia de pólipos y con pobres resultados posquirúrgicos. Conclusiones: Aun cuando la evidencia parece ser convincente en cuanto al papel de los biofilmes en la rinosinusitis crónica, todavía se necesitan estudios acerca de por qué algunos pacientes forman biofilmes, qué causas aceleran su formación, cómo prevenirlos y cómo tratarlos.

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Biofilm in Chronic Sinusitis with Nasal Polyps: Pilot study

Cited by 43 publications

References 31 publications

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Presence of Biofilms in the Lacrimal Sac Mucosa

Biofilmes: causa del manejo refractario de la rinosinusitis crónica

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