Biofilm Formation on Central Venous Catheters: A Pilot Study

Niemann, Britney; Dudas, Lauren; Gray, Dana; Pettit, Andrea; Wilson, Alison; Bardes, James M.

doi:10.1016/j.jss.2022.06.072

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Firstly, blood components can adhere to these catheters, triggering coagulation and thrombus formation [ 6 ]. In addition, catheters can act as conduits for bacterial entry, leading to microbial growth on their surfaces and biofilm formation [ 7 , 8 ]. Clinically, the administration of anticoagulants [ 9 ] and antibiotics [ 10 ] is the typical method to address these issues.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters

Ke,

Meng,

et al. 2024

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters

Ke,

Meng,

et al. 2024

Bioactive Materials

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Diagnostic performance of the (1-3)-β-d-glucan assay in patients with different risks for invasive fungal diseases

Nham,

Kim,

et al. 2024

Medical Mycology

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We evaluated the diagnostic performance of the BDG test (Beijing Gold Mountain River Tech) in diagnosing invasive fungal disease (IFD), and its variations among patients with different risks. Patients ≥ 18 years old who underwent a serum BDG test (positive cutoff value > 80 pg/mL) from April 2017 through May 2018 were collected consecutively. Patients were classified into three groups: Group 1, patients with host factors as defined by the prior 2008 European Organization for Research and Treatment (EORTC) criteria; Group 2, those with extended host factors in 2020 EORTC criteria; and Group 3, those without any risk factor mentioned in the criteria. IFD was defined by 2020 EORTC criteria, but BDG was not considered. Diagnostic performance of the serum BDG test was measured by the area under the curve (AUC) of the receiver-operating characteristic curve. Among 469 patients, 15.4% (72/469) were diagnosed with IFD (48/191 [25.1%], 14/144 [9.7%], and 10/134 [7.5%] in group 1, 2, and 3, respectively). The BDG assay showed fair performance (AUC 0.748 [95% CI, 0.688-0.810]). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 77.8%, 60.7%, 26.4%, and 93.8%. PPV was higher in group 1 and NPV was higher in group 3. Additionally, diagnostic odds ratios were 6.73, 2.88, and 5.92 in group 1, 2, and 3. Immunosuppressant use, non-invasive fungal disease/Candida colonization, and central venous catheter were associated with false positivity. Clinicians should cautiously interpret the BDG assay considering the various diagnostic performance depending on the different level of risk.

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Biofilm Formation on Central Venous Catheters: A Pilot Study

Cited by 2 publications

References 19 publications

Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters

Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters

Diagnostic performance of the (1-3)-β-d-glucan assay in patients with different risks for invasive fungal diseases

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