Biofilm formation in Acinetobacter baumannii: associated features and clinical implications

Rodríguez-Baño, Jesús; Martí, Sara; Soto, Sara M.; Fernández-Cuenca, Felipe; Cisneros, José Miguel; Pachón, Jerónimo; Pascual, Álvaro; Martínez-Martínez, Luis; McQueary, Christin N.; Actis, Luis A.; Vila, Jordi

doi:10.1111/j.1469-0691.2007.01916.x

Cited by 203 publications

(166 citation statements)

References 9 publications

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“…83%), and gentamicin (80% vs. 77%). 12 While in present study it was (71.5% vs 0%) for doxycycline, (85.7% vs 33.3%) for ceftazidime and (71.5% vs 66.6%) for gentamicin. However, ciprofloxacin resistance (66%) in their study was similar to that of our study.…”

Section: Discussioncontrasting

confidence: 52%

Study of biofilm production and antimicrobial sensitivity pattern of uropathogens in a tertiary care hospital in North India

Chaudhary

Dube

2016

Int J Community Med Public Health

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Section: Discussioncontrasting

confidence: 52%

Study of biofilm production and antimicrobial sensitivity pattern of uropathogens in a tertiary care hospital in North India

Chaudhary

Dube

2016

Int J Community Med Public Health

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“…(32). This poor correlation between clinical A. baumannii strains and the results of in vitro biofilm assays on abiotic surfaces has also been shown in another study (33). These data may suggest that biofilm formation on abiotic surfaces is not critical for the clinical success of A. baumannii, or more likely, that the biofilm assays used need to be rethought to more appropriately mimic the host environment.…”

Section: Biofilm Formation and Use Of In Vitro Abiotic Models To Studmentioning

confidence: 60%

Insights into Acinetobacter baumannii pathogenicity

2011

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SummaryAcinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a ''red-alert'' human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life-threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism.

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“…While its formation comprises the surface of the host cells and indwelling medical devices, it plays an essential role in the pathogenesis. Moreover, the presence of biofilm reduces the antibiotic penetration, leading to the development of drug resistance [33][34][35][36][37]. The CsuA/BABCDE usher-chaperone pili assembly system has been involved in A. baumannii biofilm organization on abiotic surfaces [38].…”

Section: Virulence Factorsmentioning

confidence: 99%

Acinetobacter baumannii: biology and drug resistance — role of carbapenemases

Nowak

Paluchowska

2015

Folia Histochem Cytobiol.

106

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Acinetobacter baumannii is a Gram-negative, glucose-non-fermenting, oxidase-negative coccobacillus, most commonly associated with the hospital settings. The ability to survive in adverse environmental conditions as well as high level of natural and acquired antimicrobial resistance make A. baumannii one of the most important nosocomial pathogens. While carbapenems have long been considered as antimicrobials of last-resort, the rates of clinical A. baumannii strains resistant to these antibiotics are increasing worldwide. Carbapenem resistance among A. baumannii is conferred by coexisting mechanisms including: decrease in permeability of the outer membrane, efflux pumps, production of beta-lactamases, and modification of penicillin-binding proteins. The most prevalent mechanism of carbapenem resistance among A. baumannii is associated with carbapenem-hydrolysing enzymes that belong to Ambler class D and B beta-lactamases. In addition, there have also been reports of resistance mediated by selected Ambler class A carbapenemases among A. baumannii strains. Resistance determinants in A. baumannii are located on chromosome and plasmids, while acquisition of new mechanisms can be mediated by insertion sequences, integrons, transposons, and plasmids. Clinical relevance of carbapenem resistance among strains isolated from infected patients, carriers and hospital environment underlines the need for carbapenemase screening. Currently available methods vary in principle, accuracy and efficiency. The techniques that deserve particular attention belong to both easily accessible unsophisticated methods as well as advanced techniques based on mass spectrometry or molecular biology. While carbapenemases limit the therapeutic options in A. baumannii infections, studies concerning novel beta-lactamase inhibitors offer a new insight into effective therapy.

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Biofilm formation in Acinetobacter baumannii: associated features and clinical implications

Cited by 203 publications

References 9 publications

Study of biofilm production and antimicrobial sensitivity pattern of uropathogens in a tertiary care hospital in North India

Study of biofilm production and antimicrobial sensitivity pattern of uropathogens in a tertiary care hospital in North India

Insights into Acinetobacter baumannii pathogenicity

Acinetobacter baumannii: biology and drug resistance — role of carbapenemases

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