Biofilm Formation and Pathogenesis

Bhowmik, Ankurita; Malhotra, Akshit; Jana, Sangita; Chauhan, Ashwini

doi:10.1007/978-1-0716-1378-8_1

Cited by 2 publications

(1 citation statement)

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“…Bacteria possess a unique capability to form biofilms that are ubiquitous in nature. It is a multistage and elaborate process that begins with bacterial adhesion to surfaces, followed by the synthesis of extracellular polymeric substance (EPS) matrix, development of microcolonies, and finally concludes with the dispersion of the bacterial cells from the initial [ 1 , 2 ]. The morphology of biofilms can be diverse and that mostly relies on the integral bacterial species and the circumstances under which the biofilm was originally formed [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review

et al. 2022

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Surface-associated bacterial communities called biofilms are ubiquitous in nature. Biofilms are detrimental in medical settings due to their high tolerance to antibiotics and may alter the final pathophysiological outcome of many healthcare-related infections. Several innovative prophylactic and therapeutic strategies targeting specific mechanisms and/or pathways have been discovered and exploited in the clinic. One such emerging and original approach to dealing with biofilms is the use of human milk oligosaccharides (HMOs), which are the third most abundant solid component in human milk after lactose and lipids. HMOs are safe to consume (GRAS status) and act as prebiotics by inducing the growth and colonization of gut microbiota, in addition to strengthening the intestinal epithelial barrier, thereby protecting from pathogens. Moreover, HMOs can disrupt biofilm formation and inhibit the growth of specific microbes. In the present review, we summarize the potential of HMOs as antibacterial and antibiofilm agents and, hence, propose further investigations on using HMOs for new-age therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review

et al. 2022

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Role of Diagnostic procedures in managing human Bacterial infections: A comprehensive overview

Ankurita

2023

Arch Hematol Case Rep Rev

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The study of human illnesses brought on by microbes falls under the wide category of infectious diseases. Among all other challenges, infectious diseases have a profound influence on human existence. From local epidemics to global pandemics, infectious diseases have had a huge impact on civilization growth, country destiny, and human history. Only in the late 1800s did scientists discover that infections are caused by microorganisms, leading to the development of the microbe-specific medical diagnostic technique. If identified and treated properly, many infections have mild consequences. Others, however, including pneumonia and meningitis, etc. can be fatal if neglected. With its capacity to pinpoint the precise source of infection and combat varied and widespread outbreaks, diagnostic procedures play a special role in the management of infectious diseases. Diagnosis-aid therapies work better and help the infected patient avoid long-term consequences. The most appropriate course of medication can also be decided through diagnostic testing. Patients who go undiagnosed may unintentionally spread the illness to others. A prompt diagnosis can thus contribute to the control or prevention of outbreaks. In summary, the novelty and contributions of the study lie in its recognition of the pivotal role played by diagnostic procedures in understanding, managing, and controlling infectious diseases. It also acknowledges the historical discovery of microorganisms as the root cause of infections and the development of specific diagnostic techniques, both of which have had a profound impact on the field of medicine and public health.

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Biofilm Formation and Pathogenesis

Cited by 2 publications

References 252 publications

Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review

Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review

Role of Diagnostic procedures in managing human Bacterial infections: A comprehensive overview

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