Biofilm control strategies in the light of biofilm-forming microorganisms

Kiliç, Tuğba; Bali, Elif Burcu

doi:10.1007/s11274-023-03584-6

Cited by 15 publications

(7 citation statements)

References 182 publications

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“…The first step for the formation of biofilms is the reversible attachment of cells to the surface to be colonized [ 46 ]. This process is associated with motility and with the proteins and genes that regulate adhesion [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus

Beltrán-Martínez,

Tapia-Rodríguez,

Ayala-Zavala

et al. 2024

Plants

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Staphylococcus aureus is a Gram-positive bacteria with the greatest impact in the clinical area, due to the high rate of infections and deaths reaching every year. A previous scenario is associated with the bacteria’s ability to develop resistance against conventional antibiotic therapies as well as biofilm formation. The above situation exhibits the necessity to reach new effective strategies against this pathogen. Flourensia retinophylla is a medicinal plant commonly used for bacterial infections treatments and has demonstrated antimicrobial effect, although its effect against S. aureus and bacterial biofilms has not been investigated. The purpose of this work was to analyze the antimicrobial and antibiofilm potential of F. retinophylla against S. aureus. The antimicrobial effect was determined using an ethanolic extract of F. retinophylla. The surface charge of the bacterial membrane, the K+ leakage and the effect on motility were determined. The ability to prevent and remove bacterial biofilms was analyzed in terms of bacterial biomass, metabolic activity and viability. The results showed that F. retinophylla presents inhibitory (MIC: 250 µg/mL) and bactericidal (MBC: 500 µg/mL) activity against S. aureus. The MIC extract increased the bacterial surface charge by 1.4 times and the K+ concentration in the extracellular medium by 60%. The MIC extract inhibited the motility process by 100%, 61% and 40% after 24, 48 and 72 h, respectively. The MIC extract prevented the formation of biofilms by more than 80% in terms of biomass production and metabolic activity. An extract at 10 × MIC reduced the metabolic activity by 82% and the viability by ≈50% in preformed biofilms. The results suggest that F. retinophylla affects S. areus membrane and the process of biofilm formation and removal. This effect could set a precedent to use this plant as alternative for antimicrobial and disinfectant therapies to control infections caused by this pathogen. In addition, this shrub could be considered for carrying out a purification process in order to identify the compounds responsible for the antimicrobial and antibiofilm effect.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus

Beltrán-Martínez,

Tapia-Rodríguez,

Ayala-Zavala

et al. 2024

Plants

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“…These aggregates attach to various surfaces, both living and inanimate (Sauer et al, 2022;Yao et al, 2022). The primary components of biofilms include extracellular polysaccharides (EPS), proteins, nutrient metabolites, extracellular DNA (eDNA), water, and bacteria embedded within a matrix (He et al, 2022;Hu, Ruan, et al, 2022;Hu, Zhong, et al, 2022;Kilic & Bali, 2023;. Biofilms can form in any moist or aqueous environment.…”

Section: Biofilmmentioning

confidence: 99%

Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Zhang,

Liu,

Guo

et al. 2024

WIREs Nanomed Nanobiotechnol

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The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating bacterial infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due to the slow development of new antibiotics and the increase of bacterial drug resistance. Consequently, developing new a\ntimicrobial strategies and improving antibiotic efficacy to combat bacterial infection has become an urgent priority. The emergence of nanotechnology has revolutionized the traditional antibiotic treatment, presenting new opportunities for refractory bacterial infection. Here we comprehensively review the research progress in nanotechnology‐based antimicrobial drug delivery and highlight diverse platforms designed to target different bacterial resistance mechanisms. We also outline the use of nanotechnology in combining antibiotic therapy with other therapeutic modalities to enhance the therapeutic effectiveness of drug‐resistant bacterial infections. These innovative therapeutic strategies have the potential to enhance bacterial susceptibility and overcome bacterial resistance. Finally, the challenges and prospects for the application of nanomaterial‐based antimicrobial strategies in combating bacterial resistance are discussed.This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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“…Despite recent progress, both the current and proposed anti-biofilm agents, along with their in vivo applications, necessitate thorough research to ensure their efficacy and safety in clinical contexts. Additionally, certain recent technological strides, such as enzyme engineering and DNA-based sequencing, exhibit substantial potential for more potent anti-biofilm tactics (Kilic and Bali, 2023). Achieving the transition of multiple anti-biofilm treatments from lab settings or controlled environments to real-world clinical practice demands collaborative efforts across various fields.…”

Section: Ranking Title Nc Profile Rfmentioning

confidence: 99%

A global bibliometric and visualized analysis of bacterial biofilm eradication from 2012 to 2022

Wang,

Zhang,

Chen

et al. 2023

Front. Microbiol.

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BackgroundTo deeply explore the dynamic trends, focal points and emerging topics of bacterial biofilm eradication field and provide novel insights for prospective research endeavors, the first global bibliometric and visualized analysis of the field was employed in this study.MethodsThe study meticulously curated articles and reviews concentrating on biofilm eradication from the Web of Science Core Collection (WoSCC) and identified literature published in 2012–2022 for further analysis, and the bibliometric and visualized analysis was performed to elucidate a clustering pattern in the domain with tools mainly including CiteSpace and VOSviewer.Results15,503 authors affiliated with 2,397 institutions spanning 96 countries or regions contributed to a corpus of 3,201 articles, containing 7,005 keywords. The USA emerged as a commanding vanguard in exploring the antibiofilm strategies and displaying pioneering initiatives within this sphere. The Chinese Academy of Sciences (CAS) emerged as the most prolific source of publications. Noteworthy among authors, Pandian Shunmugiah Karutha secured the lead in article contributions as well as co-citations while Deng Le with his team is poised to become a dominant influence in the future. Despite that, the extent of collaborative engagement across different institutions and authors appeared to fall short of its potential. Frontiers in Microbiology led the discourse by publishing a substantial body of articles and standing as the most recurrently co-cited publication. The most influential research domains encompassed “bacterial biofilm formation, “photodynamic therapy” and “phage therapy.” Recent trends and forefronts concentrate on intensifying research into facilitating the shift of multiple strategies for biofilm eradication from controlled lab settings or animal studies to real-world clinical environments.ConclusionFundamentally, this study presents a comprehensive scrutiny and reveals that the realm of bacterial biofilm eradication is undergoing rapid evolution, with even greater expansion anticipated in the times ahead. Subsequent scholars should emphasize the augmentation of collaborative efforts and focus their energies on emerging topics, thus contributing to break through current barriers in transitioning biofilm eradication strategies from the “fundamental” stage to “practical” application.

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Biofilm control strategies in the light of biofilm-forming microorganisms

Cited by 15 publications

References 182 publications

Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus

Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus

Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

A global bibliometric and visualized analysis of bacterial biofilm eradication from 2012 to 2022

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