Biofate and cellular interactions of lipid nanoparticles

Baldim, Iara; Oliveira, Wanderley Pereira de; Rao, Rekha; Raghuvir, Singh; Mahant, Sheefali; Gama, F. M.; Souto, Eliana B.

doi:10.1016/b978-0-12-820757-4.00015-6

Cited by 1 publication

(1 citation statement)

References 103 publications

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“…Reducing allergic response Used as cancer immunotherapy [27,28] Organ and tissue transplant rejection Enhanced vaccine efficacy [29] Very useful for autoimmune disorders and inflammation treatment Antitumorigenic [30] Undesirable Severe suppression of the immune system to a level affecting the recognition Development of inflammation [31] Myelosuppression (bone marrow and thymus gland) Development of hypersensitivity [32] Development of anaphylaxis [27] 3.…”

Section: Desirablementioning

confidence: 99%

Nanomaterials and Their Impact on the Immune System

Aljabali

Obeid

Bashatwah

et al. 2023

IJMS

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Nanomaterials have been the focus of intensive development and research in the medical and industrial sectors over the past several decades. Some studies have found that these compounds can have a detrimental impact on living organisms, including their cellular components. Despite the obvious advantages of using nanomaterials in a wide range of applications, there is sometimes skepticism caused by the lack of substantial proof that evaluates potential toxicities. The interactions of nanoparticles (NPs) with cells of the immune system and their biomolecule pathways are an area of interest for researchers. It is possible to modify NPs so that they are not recognized by the immune system or so that they suppress or stimulate the immune system in a targeted manner. In this review, we look at the literature on nanomaterials for immunostimulation and immunosuppression and their impact on how changing the physicochemical features of the particles could alter their interactions with immune cells for the better or for the worse (immunotoxicity). We also look into whether the NPs have a unique or unexpected (but desired) effect on the immune system, and whether the surface grafting of polymers or surface coatings makes stealth nanomaterials that the immune system cannot find and get rid of.

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