Biofabrication of gold nanoparticles with bone remodeling potential: an in vitro and in vivo assessment

Singh, Sneha; Gupta, Archita; Qayoom, Irfan; Teotia, Arun Kumar; Gupta, Sneha; Padmanabhan, Padmini; Dev, Abhimanyu; Kumar, Ashok

doi:10.1007/s11051-020-04883-x

Cited by 13 publications

(27 citation statements)

References 42 publications

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“…GNPs can enhance the scaffolds' mechanical strength, optimize the cells' biological osteogenic potential, efficiently deliver bioactive cues, control the bacterial infections generated during surgeries, reduce inflammation which hinders regeneration mechanism, and modulate vascularization for proper nutrient supply to the developing cells. [36,[71][72][73][74] These eminent properties of GNPs work synergistically during bone tissue repair, wherein their incorporation into the scaffolds will provide strength to the material and make them more osteoconductive for the adhesion, spreading, and growth of the cells. Simultaneously, the release of GNPs during the degradation of scaffold or the sustained release of bioactive molecules from their surface will enhance the cell proliferation, migration, and differentiation along with controlling infections and enhancing angiogenesis.…”

Section: Role Of Gnps In Maintaining Bone Healthmentioning

confidence: 99%

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Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues and Prospects

Gupta

Singh

2022

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In recent times, metal nanoparticles, especially gold nanoparticles (GNPs), have attracted considerable interest in bone regeneration and expanded many folds. Their eminence is governed by the ease in fabrication, stability, controllable size, high surface area, easy functionalization, and multifunctionality. [3] In bone tissue engineering, GNPs can extend their multifunctionality to different dimensions in modulating the fundamental elements of tissue engineering like scaffolds, cells, and bioactive cues. GNPs can improve the scaffolds' physicochemical properties, making them more suitable for bone regeneration. They also stimulate cellular functionality by enhancing adhesion, proliferation, migration, and differentiation. GNPs have already been explored for their capability in controlled delivery of the bioactive cues providing eminent therapeutic potential. Besides controlling the osseous tissue functionality, they also regulate the immunological and vascularization process propounding the tissue repair mechanism adding to extensive neo-bone formation. Gold has been considered the most stable and nontoxic metal, but its reduction to nanometric ranges changes the surface properties making them more reactive and functional than its bulk counterpart. [4] Many studies have been conducted to determine the toxicity of GNPs in biological systems. Nevertheless, mainly being safe, gold in nanometric range can exhibit toxicity depending on their size, shape, surface charge, and functionalization. Therefore, it becomes crucial to extensively study the cytocompatibility of these nanoparticles for every biological activity conferred by them.The current review focuses on exploring the multiple potentials of GNPs, which are revolutionizing the field of bone tissue engineering as regenerative therapy. The first part of the review deals with the involvement of nanoparticles in the areas of osteogenesis and how they help in remodeling the osseous tissues. The second part extensively defines the bone regenerative mechanism of GNPs through different dimensions ranging from the modulation of scaffold properties to the development of vascular networks and their interplay studies. Finally, the last part of the review unfolds the toxicological aspects of GNPs explored so far and the associated future opportunities rendered by them in bone tissue engineering.Osseous tissue repair has advanced due to the introduction of tissue engineering. The key elements required while engineering new tissues involve scaffolds, cells, and bioactive cues. The macrostructural to the nanostructural framework of such complex tissue has engrossed the intervention of nanotechnology for efficient neo-bone formation. Gold nanoparticles (GNPs) have recently gained interest in bone tissue regeneration due to their multimodal functionality. They are proven to modulate the properties of scaffolds and the osteogenic cells significantly. GNPs also influence different metabolic functions within the body, which directly or indirectly govern the mechanism of bone reg...

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Section: Role Of Gnps In Maintaining Bone Healthmentioning

confidence: 99%

“…The scaffold impregnated with GNPs (S+G) showed enhanced degradation compared to scaffold only group (S only) as analyzed through X-ray and micro-CT. Reproduced with permission. [36] Copyright 2020, Springer. Created with Biorender (biorender.com).…”

Section: Optimizing Growth and Differentiation Of Stem Cellsmentioning

confidence: 99%

Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues and Prospects

Gupta

Singh

2022

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“…GNP has the potential to be used in medical implants as an osteogenic agent that influences the stimulation of osteoblast differentiation. [ 169,170 ] Ti‐GNP promotes osteogenic differentiation in human adipose‐derived stem cells by increasing mRNA expression of osteogenic differentiation‐specific genes (ADSCs). [ 21 ] The same research group also discovered that Ti‐GNP had a significant influence on osseous interface formation in vivo.…”

Section: Biomedical Applications Of Gnpsmentioning

confidence: 99%

“…In vivo analysis from the same study also shows that GNPs have an autofluorescence property that can degrade the scaffold used as supportive and fillers for bone remodeling. [169] TA B L E 3 Recent progress of GNPs as a potential imaging and contrast agent at different diagnostics…”

Section: Medical Implantsmentioning

confidence: 99%

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Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Anik

Mahmud²,

Masud

et al. 2021

Nano Select

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Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due to their unique characteristics such as tunable surface properties as well as surface plasmon resonance (SPR), GNPs have garnered attention in various applications exclusively in therapy and diagnostics. Their ease of synthesis and compatibility with various functionalizing ligands has made them efficient and a robust biomedical platform. Due to their flexibility in synthesis and functionalization, GNPs have been profoundly used in cancer treatment as well as, antiviral, and antibacterial agents. In addition, owing to possessing unique optical properties, GNPs have been utilized as molecular imaging and contrast agent. This article discusses and highlights special characteristics of GNPs that have been exploited in biomedical applications in recent years to improve biomedical research in various biomedical field such as nuclear medicine, molecular imaging and contrast agent, vaccine development, medical implant, diagnostics, biosensing, and lab‐on‐chip applications. Moreover, their size dependent biocompatibility, biodistribution, and excreation was discussed in details for various in vivo applications. At the forefront of modern theraputic technology, GNPs based cancer treatment and antiviral agents have great potential which is also highlighted briefly in this article. In addition, current state of ongoing clinical trials and challenges associated with regulatory approval are explored. Lastly, the article sheds light on recent findings on the toxicity of GNPs and discusses the current challenges and prospects to future direct GNPs based biomedical research.

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Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Borg,

Morales,

Dorfs

et al. 2024

ChemNanoMat

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Cryogels have morphological features that make them interesting for several applications such as catalysis, sensing or tissue engineering. Their interconnected network and open porous structure, build up by primary particles (such as inorganic nanocrystals or polymers), provide these materials with unique physical properties and high specific surface areas. While the library of cryogels is endless, widely used in the polymer chemistry field, in this review we will summarize the structure and properties, applications and challenges of inorganic nanocrystal‐based cryogels obtained by freezing and freeze‐drying an aqueous nanoparticle colloid. This fast, easy and versatile gelation method will be outlined, along with the corresponding macro‐, micro‐ and nano‐structures and gel morphologies that can be obtained, for example, by changing the freezing temperature or by using one nanoparticle system or nanoparticle mixtures. Their applications towards electrocatalysis, photocatalysis and photoelectrochemical sensing will be highlighted, as well as the challenges and prospects of these materials.

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Biofabrication of gold nanoparticles with bone remodeling potential: an in vitro and in vivo assessment

Cited by 13 publications

References 42 publications

Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues and Prospects

Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues and Prospects

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

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