2017
DOI: 10.1088/1758-5090/aa6b15
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Biofabricated soft network composites for cartilage tissue engineering

Abstract: Articular cartilage from a material science point of view is a soft network composite that plays a critical role in load-bearing joints during dynamic loading. Its composite structure, consisting of a collagen fiber network and a hydrated proteoglycan matrix, gives rise to the complex mechanical properties of the tissue including viscoelasticity and stress relaxation. Melt electrospinning writing allows the design and fabrication of medical grade polycaprolactone (mPCL) fibrous networks for the reinforcement o… Show more

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Cited by 146 publications
(126 citation statements)
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References 71 publications
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“…The model solution shown in Figure 4(b) is for =0.525%, E f = 45. 4 MPa and ν f = 0.49; these parameters were obtained through a sparse parameter sweep, as described earlier.…”
Section: Comparison With Relaxation Test Experimentsmentioning
confidence: 99%
See 1 more Smart Citation
“…The model solution shown in Figure 4(b) is for =0.525%, E f = 45. 4 MPa and ν f = 0.49; these parameters were obtained through a sparse parameter sweep, as described earlier.…”
Section: Comparison With Relaxation Test Experimentsmentioning
confidence: 99%
“…Another recent study focused on the mechanical characterisation of fibrereinforced hydrogel scaffolds, measuring the properties of both the overall scaffold and individual PCL fibres; this is of great interest since knowledge of both is required to parameterise the homogenised model of this paper. While finite element modelling of fibrereinforced hydrogel scaffolds has previously been used to predict their overall mechanical properties [4], the homogenisation approach adopted here is more computationally efficient since it obviates the need to model each individual, repeating cell of the printed fibre lattice and the hydrogel contained within.…”
Section: Introductionmentioning
confidence: 99%
“…Melt electrowriting (MEW) is an emerging manufacturing technique that enables the fabrication of solvent‐free, highly organized fibrous scaffolds with micrometric features by merging principles of electrospinning and additive manufacturing . Therefore, it has the potential to overcome the limitations of the currently employed fabrication techniques by a predefined and preprogrammed fiber deposition .…”
Section: Introductionmentioning
confidence: 99%
“…The library exhibits a wide range of compressive moduli from 3.57 KPa to 6.4 MPa, which could mimic a wide range of tissues from soft tissue such as brain and adipose tissue to stiffer cancellous bone. 18,22,23 As shown in Figures 6 and 7, the compressive moduli (E) of the hydrogels increased with PEG-DA concentration. Through a combination of prolation and subsequent molecular relaxation by removal of the porogen, decreasing material stiffness was achieved.…”
Section: Physicochemical Characterization Of Crosslinked Hydrogelmentioning
confidence: 76%