Bioextracting Polyphenols from the Brown Seaweed <i>Ascophyllum nodosum</i> from Québec's North Shore Coastline

Poole, Jessica; Diop, Amadou; Rainville, Louis-Charles; Barnabé, Simon

doi:10.1089/ind.2019.0008

Cited by 22 publications

(16 citation statements)

References 25 publications

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“…To overcome such problems, several researchers tested a mixture of water and ethanol in different mixing ratios. Several studies optimized the extraction parameters using statistical models, so that they could get the maximum polyphenol compounds with a possible combination of extraction parameters [ 26 , 27 , 61 , 62 , 63 , 64 ].…”

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applications in, e.g., food, cosmetics, and pharmaceutical industries. To survive in a very harsh and challenging environment, marine organisms like several seaweed (macroalgae) species produce and accumulate several secondary metabolites, including marine phenolics in the cells. Traditionally, these compounds were extracted from their sample matrix using organic solvents. This conventional extraction method had several drawbacks such as a long extraction time, low extraction yield, co-extraction of other compounds, and usage of a huge volume of one or more organic solvents, which consequently results in environmental pollution. To mitigate these drawbacks, newly emerging technologies, such as enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) have received huge interest from researchers around the world. Therefore, in this review, the most recent and emerging technologies are discussed for the extraction of marine phenolic compounds of interest for their antioxidant and other bioactivity in, e.g., cosmetic and food industry. Moreover, the opportunities and the bottleneck for upscaling of these technologies are also presented.

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Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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“…One of the most significant groups of compounds that determine the biomedical importance of marine algae is polyphenols (PP). Algae accumulate large amounts of these compounds, including, in particular, phloroglucinol and its polymers, phlorotannins (PT) [ 5 , 6 ]. Currently, scientists from many countries are showing increasing interest in these compounds, which is manifested as an increase in the number of publications on problems related to their biological activity worldwide [ 7 , 8 , 9 ].…”

Section: General Characteristics Of Polyphenolic Compounds From Mamentioning

confidence: 99%

“…Such extracts are also characterized by the highest antioxidant activity. In recent years, the results of the most efficient production of algae extracts using different extractants and extraction methods have been reported in numerous studies [ 6 , 7 , 40 , 43 ].…”

Section: Obtaining Polyphenols From Marine Algaementioning

confidence: 99%

Algae Polyphenolic Compounds and Modern Antibacterial Strategies: Current Achievements and Immediate Prospects

et al. 2020

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The increasing drug resistance of pathogenic microorganisms raises concern worldwide and necessitates the search for new natural compounds with antibacterial properties. Marine algae are considered a natural and attractive biotechnological source of novel antibiotics. The high antimicrobial activity of their polyphenolic compounds is a promising basis for designing innovative pharmaceuticals. They can become both a serious alternative to traditional antimicrobial agents and an effective supplement to antibiotic therapy. The present review summarizes the results of numerous studies on polyphenols from algae and the range of biological activities that determine their biomedical significance. The main focus is put on a group of the polyphenolic metabolites referred to as phlorotannins and, particularly, on their structural diversity and mechanisms of antimicrobial effects. Brown algae are an almost inexhaustible resource with a high biotechnological potential for obtaining these polyfunctional compounds. An opinion is expressed that the effectiveness of the antibacterial activity of phlorotannins depends on the methods of their extraction aimed at preserving the phenolic structure. The use of modern analytical tools opens up a broad range of opportunities for studying the metabolic pathways of phlorotannins and identifying their structural and functional relationships. The high antimicrobial activity of phlorotannins against both Gram-positive and Gram-negative bacteria provides a promising framework for creating novel drugs to be used in the treatment and prevention of infectious diseases.

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“…They protect the seaweed thallus against biotic and abiotic stresses such as predation from herbivores, microbial infection, oxidation, and UV damage [ 153 ]. The total polyphenolic content of brown seaweed (dry mass) can be as high as 20%, while green and red seaweeds contain 1–5% [ 154 , 155 , 156 ]. The molecular weight of seaweed polyphenols ranges from approximately 26 Da to 650 kDa [ 157 , 158 ].…”

Section: Discussionmentioning

confidence: 99%

Seaweed Components as Potential Modulators of the Gut Microbiota

2021

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Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. However, it is also necessary to confirm these potential, therapeutic effects in large-scale clinical trials. Where possible, we have cited information concerning these trials.

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Bioextracting Polyphenols from the Brown Seaweed Ascophyllum nodosum from Québec's North Shore Coastline

Cited by 22 publications

References 25 publications

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Algae Polyphenolic Compounds and Modern Antibacterial Strategies: Current Achievements and Immediate Prospects

Seaweed Components as Potential Modulators of the Gut Microbiota

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