Examples are given of the application of bioestimation-a conceptually new hydrobiological method used to control the process of water quality formation. This paper is the continuation of the paper "Bioestimation: A New Method for the Control of Water Self Purification Process and Its Comparison with Bioindication". The experience in the use of bioestimation in water bodies with different use type, size, salin ity, flowage, and geographic position confirmed its universal character, information value, promptness, and the possibility to limit the volume of sample to be sent to 10-20 cm 3 , thus simplifying the field works. Each significant factor, which affects the self purification process, is identified independently, since the bioestima tors reflecting it are biotically independent; their number varies depending only on changes in the environ mental factors that are external with respect to the community of environmental factors. Bioestimation shows prognostic properties, since it makes it possible to prevent water quality deterioration and to restore the nor mal course of water self purification at the stage of its quality formation. The use of bioestimation will extend the positive anthropogenic impact on water bodies.