Bioequivalence assessment of closerin capsule to Dura seromycin capsule of cycloserine after a single oral dose administration to healthy male volunteers

Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study

“…Cycloserine was rapidly absorbed, reaching peak plasma concentrations approximately 0.84 hours after oral administration, and the t ½ in plasma was about 13.0 hours, which were comparable with the previous studies, 9,10 in which Korean and white subjects were enrolled.…”

“…8 The terminal half-life of cycloserine is 8 to 12 hours. 9,10 A literature search of MEDLINE was conducted using the following terms: cycloserine, pharmacokinetics, bioequivalence, and Chinese. Although there were several pharmacokinetic studies in white, 10 Korean, 9 and Indian 11 populations, no reports were identified concerning the pharmacokinetic properties of cycloserine in a Chinese population.…”

“…9,10 A literature search of MEDLINE was conducted using the following terms: cycloserine, pharmacokinetics, bioequivalence, and Chinese. Although there were several pharmacokinetic studies in white, 10 Korean, 9 and Indian 11 populations, no reports were identified concerning the pharmacokinetic properties of cycloserine in a Chinese population. Therefore, the objective of our single-and multiple-dose study was to determine the pharmacokinetic properties and tolerability of a generic formulation of cycloserine in healthy Chinese adult volunteers.…”