Bioenzyme-responsive<scp>l</scp>-arginine-based carbon dots: the replenishment of nitric oxide for nonpharmaceutical therapy

Han, Chuyi; Yu, Qinghua; Jiang, Junhao; Zhang, Xianming; Wang, Fan; Jiang, Mingyue; Yu, Ruijin; Deng, Tao

doi:10.1039/d1bm01184g

Cited by 12 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the antitumor effect observed in the AM(B)LD+NIR group, where PTT was combined with NO under NIR irradiation, was significantly superior to that in the AM(B)LD group ( p < 0.001). There are various pathways that stimulate NO production, such as pH, enzymes, and NIR . However, in contrast to the currently reported NO therapy literature, , our system uniquely combined the dual functionalities of inducing NO production under NIR irradiation and serving as an initiator for PTT.…”

Section: Resultsmentioning

confidence: 99%

Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy

Wang,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Nitric oxide (NO) intervenes, that is, a potential treatment strategy, and has attracted wide attention in the field of tumor therapy. However, the therapeutic effect of NO is still poor, due to its short half-life and instability. Therapeutic concentration ranges of NO should be delivered to the target tissue sites, cell, and even subcellular organelles and to control NO generation. Mitochondria have been considered a major target in cancer therapy for their essential roles in cancer cell metabolism and apoptosis. In this study, mesoporous silicon-coated gold nanorods encapsulated with a mitochondria targeted and the thermosensitive lipid layer (AuNR@MSN-lipid-DOX) served as the carrier to load NO prodrug (BNN6) to build the near-infrared-triggered synergetic photothermal NO-chemotherapy platform (AuNR@MSN(BNN6)-lipid-DOX). The core of AuNR@MSN exhibited excellent photothermal conversion capability and high loading efficiency in terms of BNN6, reaching a high value of 220 mg/g (w/w), which achieved near-infrared-triggered precise release of NO. The outer biocompatible lipid layer, comprising thermosensitive phospholipid DPPC and mitochondrial-targeted DSPE-PEG2000-DOX, guided the whole nanoparticle to the mitochondria of 4T1 cells observed through confocal microscopy. In the mitochondria, the nanoparticles increased the local temperature over 42 °C under NIR irradiation, and a high NO concentration from BNN6 detected by the NO probe and DSPE-PEG2000-DOX significantly inhibited 4T1 cancer cells in vitro and in vivo under the synergetic photothermal therapy (PTT)–NO therapy–chemotherapy modes. The built NIR-triggered combination therapy nanoplatform can serve as a strategy for multimodal collaboration.

show abstract

Section: Resultsmentioning

confidence: 99%

Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy

Wang,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…l -Citrulline has minimal deleterious effects on the human body, making l -Arg a perfect NO donor medication. Recent research indicates that l -Arg, for the purpose of donor-mediated NO release, has a positive therapeutic impact in the treatment of cervical cancer, breast cancer, glioma, and other malignancies without causing side effects . By creating a nanoplatform that produces oxidative photogenerated holes in reaction to light, Xiao and co-workers oxidize arginine residues to create NO when 660 nm laser light is applied.…”

Section: Small Molecular Weight No Donorsmentioning

confidence: 99%

“…Recent research indicates that L-Arg, for the purpose of donormediated NO release, has a positive therapeutic impact in the treatment of cervical cancer, breast cancer, glioma, and other malignancies without causing side effects. 57 By creating a nanoplatform that produces oxidative photogenerated holes in reaction to light, Xiao and co-workers oxidize arginine residues to create NO when 660 nm laser light is applied. The in vitro and in vivo findings indicated that poly-L-arginine-modified carbon-dots-doped graphitic carbon nitride nanomaterial ArgCCN has the capacity to produce NO effectively in both positive and hypoic settings and to trigger apoptosis in tumor cells when exposed to laser light.…”

Section: N-diazeniumdiolatesmentioning

confidence: 99%

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Huang

Zhang

Luo

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while the extremely short half-life and nonspecific distribution of NO greatly limit its further clinical applications. Thus, the past few decades have witnessed the progress made in conquering these shortcomings, including developing innovative NO donors, especially smart and multimodal nanoplatforms. These platforms can precisely control the spatiotemporal distribution of therapeutic agents in the organism, which make big differences in tumor treatment. Here current NO therapeutic mechanisms for cancer, NO donors from small molecules to smart-responsive nanodrug delivery platforms, and NObased combination therapy are comprehensively reviewed, emphasizing outstanding breakthroughs in these fields and hoping to bring new insights into NO-based tumor treatments.

show abstract

“… 25 , 26 Among them, L-arginine (L-Arg), as a substrate for inducible nitric oxide synthases (iNOS), is a promising NO donor in response to endogenous hydrogen peroxide (H 2 O 2 ) to produce NO. 27 , 28 However, the application of L-Arg is compromised by its poor cellular internalization and nontargeted biodistribution. Furthermore, similar to ROS, NO and RNS are very reactive and have difficulty reaching the mitochondria.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria-Targeted Mesoporous Titanium Dioxide Nanoplatform for Synergistic Nitric Oxide Gas-Sonodynamic Therapy of Breast Cancer

Zuo

Zhang

Wang

et al. 2022

IJN

View full text Add to dashboard Cite

Background Sonodynamic therapy (SDT) has rapidly advanced as a promising alternative to conventional photodynamic therapy owing to its preferable therapeutic depth. However, single-modal SDT exhibits limited efficacy due to the long-term hypoxia in tumors. Method and Results To address these issues, we proposed a synergistic SDT strategy that integrates mitochondrial targeting with nitric oxide (NO) gas therapy by using multifunctional nanoplatforms. The nanoplatform, which was named as T-mTNPs@L-Arg, was composed of mesoporous titanium dioxide loaded with the NO donor precursor L-arginine (L-Arg) and modified with triphenyl phosphonium (TPP), a mitochondria-targeting ligand. Therefore, T-mTNPs@L-Arg could efficiently concentrate into mitochondria and release NO gas as well as generate reactive oxygen species (ROS) with ultrasound stimulus. Importantly, the released NO gas exerted multiple synergies with SDT, including inducing NO poisoning, generating more lethal reactive nitrogen species (RNS) by reaction with ROS, and alleviating hypoxia through NO-mediated mitochondrial respiration inhibition. On account of the synergistic effects, T-mTNPs@L-Arg showed an outstanding SDT efficacy and a reduced side effect. Conclusion This work designed a nanoplatform to integrate mitochondria targeting, SDT and NO gas therapy, providing a new strategy for highly efficient breast cancer therapy.

show abstract

Bioenzyme-responsivel-arginine-based carbon dots: the replenishment of nitric oxide for nonpharmaceutical therapy

Abstract: Nitric oxide (NO) is a short-lived, bioactive gas which has been affinitive to cardiovascular diseases as well as cancer biology, and the deficiency of NO may cause serious pathological responses....

Cited by 12 publications

References 49 publications

Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy

Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Mitochondria-Targeted Mesoporous Titanium Dioxide Nanoplatform for Synergistic Nitric Oxide Gas-Sonodynamic Therapy of Breast Cancer

Contact Info

Product

Resources

About