Abstract:The prevalence of obesity is increasing worldwide. Obesity is associated with a number of health related problems, so treating obesity is an important clinical concern. Intra-gastric balloon (IGB) represents, in the short-term, an alternative for obese patients non responding to diet and reluctant to surgery. Use of intragastric balloon for 6 months significantly reduces body weight and BMI. Moreover, Intragastric balloon strongly affects glucose homeostasis, lipid metabolism in addition to hormones involved in energy balance mainly serum leptin and ghrelin.