Bioenhancers: Revolutionary concept to market

Atal, Navin; Bedi, K. L.

doi:10.4103/0975-9476.65073

Cited by 107 publications

(76 citation statements)

References 9 publications

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“…Ginger is known to enhance the bioavailability by regulating the GIT function [20]. Although there are reports which indicate that use of ginger extract enhances the bioavailability of many drugs [21][22][23], we did not get satisfactory results , which is suggestive that bioenhancers working on the gut motility may not be the right candidates to be studied by this method. It may also be possible that the ginger extract might be forming a coating over the mucosal surface thereby hindering the absorption of Amoxicillin trihydrate.…”

Section: In Vitro Studies Using Non Everted Gut Sac Methodscontrasting

confidence: 53%

Effect of Bioenhancers on Amoxicillin bioavailability

Barve

Ruparel

2015

ADMET DMPK

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Section: In Vitro Studies Using Non Everted Gut Sac Methodscontrasting

confidence: 53%

Effect of Bioenhancers on Amoxicillin bioavailability

Barve

Ruparel

2015

ADMET DMPK

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“…However in general, this type of release profile potentially can cross the toxic drug-concentration level within initial hours and sub therapeutic drug concentration in later part [23]. As piperine is the most formidable bio-enhancer till date, it helps to enhance the bio-availability of other drugs by boosting the absorption from the intestine [24]. It also has anti-microbial, anti-inflammatory, anti-depressant, anticancerous effects [25][26][27] apart from being hydrophobic in nature.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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“…Sometimes, this type of positive pharmacokinetic interactions beyond certain degree are deliberately used to improve the exposure of drugs that also eventually beneficial for poor bioavailable drugs or drugs having dose dependent side effects to reduce dose. 8 Common mechanisms of curcumin for pharmacokinetic interactions as evidenced from literature are modulated through down regulation of CYP450, followed by P-gp and a few downstream pathways involving OATP, glutathione-S-transferase (GST) and uridine dinucleotide phosphate glucuronosyltransferases (UDPG). Based on in-vitro studies reported data, curcumin could inhibit P-gp in dose dependent manner at micromolar concentration range and inhibit CYP3A4 competitively with low potency of more than 10 μM.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas, dose of curcumin (2.5/5/10 mg/kg) was on the basis of bioenhancer mechanism which function at low doses. 8 Individual dose was prepared as solution form using 10% DMSO, 20% solutol HS15 and water (q.s) for oral administration of curcumin and daclatasvir dihydrochloride.…”

Section: Dose Selection and Preparationmentioning

confidence: 99%

Impact of Concomitantly Administered Curcumin on Pharmacokinetics of Daclatasvir in Mice Under the Frame of Herb-Drug Interaction

Magotra¹,

Kotwal²,

Bhatt³

et al. 2018

IJPER

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Objective: Daclatasvir is a new orally acting antiviral drug for the treatment of hepatitis C virus (HCV). It is substrate of both P-glycoprotein (P-gp) and CYP3A4 which are involved in the major pharmacokinetic interaction between drug-drug or drug-food. Curcumin, a natural polyphenol extracted from Curcuma longa is used regularly and widely as food additive or dietary supplement. We surmised that curcumin may interfere with the pharmacokinetics of daclatasvir as curcumin is known to have potential to hinder the drug transporters and hepatic drug metabolising enzymes. Hence, investigations were taken up to assess for such possible interactions. Materials and Methods: Pharmacokinetics of daclatasvir after oral administration as alone and in combination with curcumin (2.5 or 5 or 10 mg/kg) were investigated in Balb/C mice following determination of daclatasvir plasma concentration by using a sensitive LC-MS/MS method. Results: Area under the plasma concentration-time curve for daclatasvir was decreased at lowest dose and increased subsequently at higher doses upon concomitant administration of curcumin with daclatasvir in comparison to daclatasvir alone. Maximum plasma concentration of daclatasvir was enhanced only at highest dose. Overall effects of curcumin on daclatasvir pharmacokinetics were not statistically significant at all dose levels except significant increase in mean residence time. Conclusion: Intensity of curcumin effect on the daclatasvir pharmacokinetics at the experimental dose level in the mice model suggests that dose adjustment is unlikely to be required. Further experimentations are needed to confirm its clinical significance.

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Bioenhancers: Revolutionary concept to market

Cited by 107 publications

References 9 publications

Effect of Bioenhancers on Amoxicillin bioavailability

Effect of Bioenhancers on Amoxicillin bioavailability

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Impact of Concomitantly Administered Curcumin on Pharmacokinetics of Daclatasvir in Mice Under the Frame of Herb-Drug Interaction

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