Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications

Yadav, Renuka; Saini, Himanshu; Kumar, Dinesh; Pasi, Shweta; Agrawal, Veena

doi:10.1016/j.msec.2019.109984

Cited by 53 publications

(28 citation statements)

References 43 publications

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“…At the same time, most of the proposed NPs seemed to have a good efficiency against the various tumoral cells, with half maximal effective concentrations usually under 100 mg/L. For example, against breast adenocarcinoma cells (MCF-7), the best results in the MTT assay were achieved by using spherical silver nanoparticles that were obtained by using Tropaeolum majus L. leaf extracts (EC 50 = 2.49 mg/L) [24], followed by spherical gold nanoparticles that were obtained by using Anacardium occidentale L. leaves (EC 50 = 6 mg/L) [53]; the same types of NPs were also found to be efficient against human cervical epithelioid carcinoma cells (HeLa) (Ag NPs that were obtained by using Piper longum leaves-EC 50 = 5.27 mg/L [88] and Au NPs that were obtained by using Alternanthera sessilis leaves-EC 50 = 10 mg/L [99]), while the most effective nanoparticles against human lung carcinoma cells (A549) were proven to be silver NPs that were obtained by using Scorzonera calyculata aerial parts (EC 50 = 12.5 mg/L) [35], gold NPs that were obtained by using Marsdenia tenacissima leaves (EC 50 = 15 mg/L) [95], MgO NPs that were obtained by using Sargassum wightii (EC 50 = 37.5 mg/L) [70], and ZnO NPs that were obtained by using Allium cepa leaves (EC 50 = 51.25 mg/L) [66].…”

Section: Antitumoral Applicationsmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

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Section: Antitumoral Applicationsmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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“…Many research lab and departments are focused on the field and thinking about how to enhance the efficacy of these products. Currently, green synthesis of silver nanoparticles appears to be potential future for controlling mosquito vectors because these particles enhance the bioefficacy of plant extracts (Kumar et al 2018a, b;Saini et al 2019;Yadav et al 2019). Enhanced toxic effect of silver nanoparticles towards the microorganisms increased due to wrapping of plant extract on AgNP surface and high penetration power (Kumar et al 2018a, b).…”

Section: Standardizing the Chemical Composition And Quality Of Plant mentioning

confidence: 99%

“…Recently, plant-derived silver nanoparticles have also emerged as an alternative tool and received extraordinary attention as potent larvicidal agents in recent past (Santhosh et al 2015). Silver nanoparticles have been synthesized using Annona reticulata Linnaeus (Parthiban et al 2019), Chasmanthera dependens Hochst (Aina et al 2019), Ceropegia bulbosa Roxburgh (Vetrivel et al 2019), Piper longum Linnaeus (Yadav et al 2019), Cullen corylifolium Linnaeus (Saini et al 2019), Curcuma zedoaria Roscoe (Sutthanont et al 2019), Naringi crenulata Roxburgh (Pratheeba et al 2019), and Avicennia marina Forsskål (Barnawi et al 2019); they exhibit tremendous larvicidal potential against various mosquito vectors. Herbal silver nanoparticles have several advantages over the chemically synthesized silver nanoparticles like eco-friendly, cost-effective, single-step synthesis, and an easy control of crystal growth, and also, they are non-toxic and safe to handle (Iravani 2011; Salam et al 2012;Shah et al 2016;Benelli 2016a;Das et al 2017;Murugan et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Herbal silver nanoparticles have several advantages over the chemically synthesized silver nanoparticles like eco-friendly, cost-effective, single-step synthesis, and an easy control of crystal growth, and also, they are non-toxic and safe to handle (Iravani 2011; Salam et al 2012;Shah et al 2016;Benelli 2016a;Das et al 2017;Murugan et al 2017). Furthermore, herbal silver nanoparticles do not have any side effect against nontargeted organisms over the conventional chemical insecticides (Duan et al 2015;Benelli 2016a;Kumar et al 2018a, b;Saini et al 2019;Yadav et al 2019). But a few of them have been reported with green synthesized silver nanoparticles for their larvicidal activity against the larvae of various mosquito species.…”

Section: Introductionmentioning

confidence: 99%

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Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges

Kumar

Singh

et al. 2020

Environ Sci Pollut Res

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Mosquitoes spread several life-threatening diseases such as malaria, filaria, dengue, Japanese encephalitis, West Nile fever, chikungunya, and yellow fever and are associated with millions of deaths every year across the world. However, insecticides of synthetic origin are conventionally used for controlling various vector-borne diseases but they have various associated drawbacks like impact on non-targeted species, negative effects on the environment, and development of resistance in vector species by alteration of the target site. Plant extracts, phytochemicals, and their nanoformulations can serve as ovipositional attractants, insect growth regulators, larvicides, and repellents with least effects on the environment. Such plant-derived products exhibit broad-spectrum resistance against various mosquito species and are relatively cheaper, environmentally safer, biodegradable, easily accessible, and are non-toxic to non-targeted organisms. Therefore, in this review article, the current knowledge of phytochemical sources exhibiting larvicidal activity and their variations in response to solvents used for their extraction is underlined. Also, different methods such as physical, chemical, and biological for silver nanoparticle (AgNPs) synthesis, their mechanism of synthesis using plant extract, their potent larvicidal activity, and the possible mechanism by which these particles kill mosquito larvae are discussed. In addition, constraints related to commercialization of nanoherbal products at government and academic or research level and barriers from laboratory experiments to field trial have also been discussed. This comprehensive information can be gainfully employed for the development of herbal larvicidal formulations and nanopesticides against insecticide-resistant vector species in the near future.

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“…Currently, SNP-mediated biogenic sources that are chosen to substitute toxic chemical methods have shown significant potential in reducing polluting reaction by-products. The "green" nanotechnologies are advantageous over physical and chemical methods and exploit economical and ecofriendly methods by using an available and non-toxic medium, such as medicinal plants that leads to the green synthesis of SNPs [5][6][7][8]. The application of medicinal plants in the formation of SNPs has prompted numerous investigations in the field of "green" nanotechnologies.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on Physicochemical, Photocatalytic, and Biological Properties of Silver Nanoparticles Formed Using Extracts of Different Parts of Cudrania tricuspidata

et al. 2020

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Green-synthesized silver nanoparticles (SNPs) have great potential for biomedical applications, due to their distinctive optical, chemical, and catalytic properties. In this study, we aimed to develop green-synthesized SNPs from extracts of Cudrania tricuspidata (CT) roots (CTR), stems (CTS), leaves (CTL), and fruit (CTF) and to evaluate their physicochemical, photocatalytic, and biological properties. CTR, CTS, CTL, and CTF extracts were evaluated and compared for their total phenol and flavonoid content, reducing capacity, and antioxidant activity. The results revealed that CTR, CTS, CTL, and CTF extracts have high phenol and flavonoid content, as well as a powerful antioxidant and reducing capacity. CTR and CTS extracts showed the strongest effects. The results from UV-Vis spectra analysis, dynamic light scattering, high-resolution transmission electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy showed the successful formation of CT-SNPs with surface morphology, crystallinity, reduction capacity, capsulation, and stabilization. Synthesized CT-SNPs successfully photocatalyzed methylene blue, methyl orange, rhodamine B, and Reactive Black 5 within 20 min. The CTR- and CTS-SNPs showed better antibacterial properties against different pathogenic microbes (Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella enteritidis) than the CTL- and CTF-SNPs. CTS- and CTR-SNPs showed the most effective cytotoxicity and antiapoptosis properties in human hepatocellular carcinoma cells (HepG2 and SK-Hep-1). CT-SNPs also seemed to be more biologically active than the CT extracts. The results of this study provide evidence of the establishment of CT extract SNPs and their physicochemical, photocatalytic, and biological properties.

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Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications

Cited by 53 publications

References 43 publications

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges

A Comparative Study on Physicochemical, Photocatalytic, and Biological Properties of Silver Nanoparticles Formed Using Extracts of Different Parts of Cudrania tricuspidata

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